[PDF] Top 20 Functional Connectomics in C. elegans
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Functional Connectomics in C. elegans
... this functional circuit acts in a seemingly unorthodox manner, as it defies classical circuit logic of sensory to motor organization: motor and interneurons modulate the activity of sensory neurons ... See full document
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Topological measures of connectomics for low grades Glioma
... and functional MRI (fMRI) activations have been reported [3, 4, ...of functional activations highlights only the activations related to the task, but not the interaction among areas or the effect among the ... See full document
13
Connectomics in psychiatric research: advances and applications
... decreased functional connectivity in ...altered functional connectivity in ...weaker functional connectivity in the autistic population than in the controls are shown in blue, and the voxels that ... See full document
10
Analysis of xbx genes in C elegans
... Unlike those in group 1, the roles of many genes in group 2 are largely unknown. To begin the functional investigation of the second group we analyzed two genes, xbx-4 and xbx-6, mutants of which were available. ... See full document
12
Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C elegans and its functional response to drugs
... Fig. 2. Effect of pharmacological interventions on nematode strength. The strengths for three different strains, each with a control and four treatments, are shown here. Each strain was treated with melatonin and ... See full document
36
Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system
... Fig. 3 The effect of human neuropeptide receptors on bordering and MeSa avoidance behavior of npr-1 null nematodes. a Assay layout for determining the bordering behavior of C. elegans nematodes. Adult ... See full document
15
Taurine reduces ER stress in C. elegans
... Taurine is known to help cells recover from damage, and to prevent physiological stress by adjusting osmolar- ity. Under cellular stress conditions, taurine maintains the cellular homeostasis by achieving an osmotic ... See full document
6
Of what use is connectomics? A personal perspective on the Drosophila connectome
... interpret functional interactions revealed either by imaging ...while functional and empirical, in most cases still lack an experimental foundation based on detailed knowledge on signalling and postsynaptic ... See full document
10
Metabolic regulation of lifespan from a C. elegans perspective
... In C. elegans, the sphingoid base is produced from the condensation of serine and branched-chain fatty acid C15:iso to form d17:iso-sphinganine ...of C. elegans [63] and deletion of both hyl-1 ... See full document
12
Identification of functional long non-coding RNAs in C. elegans
... functional has long been debated because of their low ex- pression levels and rapid evolutionary turnover when compared to protein-coding genes [6, 7]. However, the molecular activities of more than a hundred of ... See full document
14
Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C elegans muscle
... product functional interaction data from a published meta- analysis, to construct potential functional networks for the kinases identi fi ed in each ...the C. elegans kinase and/or data for the ... See full document
13
On predicting regulatory genes by analysis of functional networks in C. elegans
... of functional networks from the known pair-wise connectivity between biological molecules offers systems level insights into complex biological processes ...of functional links between ...of ... See full document
16
Transfer at C. elegans Synapses
... To depolarize AFD selectively and remotely, we expressed chR2 under the gcy-8 promoter, which is exclusively expressed in AFDL and AFDR (Figure 2.1B). Worms were fed the co-factor all-trans retinal (ATR), necessary for ... See full document
89
The mevalonate pathway in C. elegans
... that C. elegans lack cholesterol synthesis machinery ...in C. elegans are vitellogenins, homologues of mammalian apolipoproteins; these pro- teins are required for transporting sterols from ... See full document
12
Regulation of Tissue-Specific Expression in the C. Elegans Embryo
... Knowledge of when and in which cells each gene is expressed across multicellular organisms is critical in understanding both gene function and regulation of cell type diversity. However, methods for measuring expression ... See full document
168
The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2
... 2015). C. elegans lacks a Keap1 ortholog; however, the C. elegans protein WDR-23 (which interacts with the CUL-4/DDB-1 complex) acts analogously by target- ing SKN-1 for degradation, thus ... See full document
14
Gait modulation in C. elegans: An integrated neuromechanical model
... Our model contains a number of essential ingredients. First, to adapt the neural activity patterns to the different media, the proprioceptive (or stretch receptor) signal must span a sufficient length of the body. ... See full document
16
Acto myosin reorganization and PAR polarity in C elegans
... The C. elegans embryo is an excellent model system in which to address polarity ...one-cell C. elegans embryos is defined by two coordinated cortical polarities: PAR polarity and contractile ... See full document
9
Insulin signaling promotes germline proliferation in C elegans
... To investigate further the germline versus soma activity of pathway components, we tested the efficacy of RNAi knockdown of several pathway components in the rrf-1 mutant background that reduces RNAi effectiveness in the ... See full document
11
Analysis of centriole elimination during C elegans oogenesis
... Fig. 6. CGH-1 promotes timely centriole elimination. (A-C) Region 4 from young adult hermaphrodites of the indicated genotypes stained for -tubulin (green), SAS-4 (red in the merged images and shown with DNA in ... See full document
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