[PDF] Top 20 The functional role of long non-coding RNAs and epigenetics

... There are CpG islands in the upstream region of the miR-375 gene and aberrant DNA methylation in this gene can be observed in specific melanoma stage [115,116]. His- tone modification of DNA methylation is one vital ... See full document

... protein coding region of the ...protein coding [9, 10]. LncRNAs are a group of non- coding RNAs that have several recent discoveries linked to cancer ...a functional role ... See full document

... small RNAs which are differentially expressed in tissues or cell ...specific functional role to this ob- servation without further experimental examination of Malat1 functions in the given ... See full document

... the role of lncRNA in DNA methylation in cancer, the participation of nucleosome positioning in tumours is less well ...the role of lncRNAs in some ... See full document

... In recent years, it has been reported that more than 90% of the human genome has been actively transcribed, yet less than 3% of the total human sequence encodes proteins, with the majority of the genome transcribed to ... See full document

... secondary and higher order structures that provides higher accessibility to both proteins and target recognition sites (Batista and Chang, 2013; Guttman and Rinn, 2012; Rinn and Chang, 2012). The flexible (Zappulla and ... See full document

... tumor-suppressive role by both p53-independent and p53-dependent path- ...in non-small cell lung cancer by activating the EGFR/PI3K/AKT pathway ...their role in tumor metabolism by regulating p53, ... See full document

... DOI: 10.4236/ojog.2018.82017 134 Open Journal of Obstetrics and Gynecology gene cluster. ANRIL was first identified in a genetic analysis of melanoma with neural tumors [18]. ANRIL is intensely associated with a genetic ... See full document

... Non-coding RNAs (ncRNA) are implicated in several epigenetic processes, notably small RNAs that can influence histone modifications and cytosine methylation which are connected with gene ... See full document

... potential coding sequences is ribosome profiling (Ingolia et ...for functional peptide products because their peptide sequences are not conserved, even though their presence in the 5 ⬘ leader may be (Hood ... See full document

... XIst is a major player in the complex mechanism leading to heterochromatinization and subsequent transcriptional inactivation of one of the two X chromosomes in women, a phenomenon necessary for dosage compensation. A ... See full document

... a role in telomere- end processing by controlling its spatially proximal ...trans-acting role and, therefore, in contrast to current evidence in the literature, we anticipate that a con- siderable number of ... See full document

... LncRNA H19, which play important roles in liver CSCs self-renewal, can also affect the function of prostate CSCs. Lei Li and other researchers have found that after andro- gen blockade therapy in prostate cancer, a large ... See full document

... Breast cancer is the second most common cancer in women in the U.S. based on the latest information from American Cancer Society (www.cancer.org). In 2015 about 231,840 new cases of invasive breast cancer will be ... See full document

... Apart from acting within a given cell, intercellular communication via vesicle-mediated transport of lncRNAs, as well as small ncRNAs and mRNAs, emerges as relevant physiological and developmentary mechanisms [197-199], ... See full document

... these RNAs are denoted as long non-coding RNAs (lncRNAs) which function as signaling mol- ecules, navigating systems and platforms for ribonu- cleic complexes ...crucial role in ... See full document

... then long non-coding RNAs (lncRNAs) are located at the other: most multi- exonic lncRNA loci exhibit little or no cross-vertebrate sequence conservation ...by functional elements con- ... See full document

... small non-coding RNAs ...the role of various classes of sRNAs at different levels of gene regulation and ...sufficient functional annotation, however, make integration of these datasets ... See full document

... in non-stimulated bone marrow-derived macrophages (BMDMs) and increase the expression of 713 genes in BMDM following stimulation with the synthetic bacterial triacylated lipopeptide Pam3- Cys-Ser-Lys4 ...a ... See full document

... has long been debated because of their low ex- pression levels and rapid evolutionary turnover when compared to protein-coding genes [6, ...other RNAs, in- cluding mRNAs, lncRNAs, or microRNAs ... See full document