[PDF] Top 20 Genetic factors in systemic sclerosis

... of genetic loci have been identified that appear to be associated with systemic sclerosis (SSc; ...these genetic associations may in fact be associated with distinct phenotypes in SSc based on ... See full document

... The mechanisms underlying the link between obesity and OA are complex. Joint loading has been considered an important role in this relationship; however, obesity not only confers an increased risk of weight-bearing ... See full document

... Likewise we included healthy women matched one to one with patients on age (+/- 4 years), body mass index (BMI) (+/- 3 kg/m²) and duration of menopause (+/- 1 year). Controls were selected from a database obtained from ... See full document

... neous systemic sclerosis (dcSSc) subtype was present in these studies compared with our study, although Kaloudi and colleagues [23] found no significant differences between mean IMT between ... See full document

... 6MWD 6-minute walk distance, ACA anti-centromere antibodies, ARA anti-RNA polymerase III antibodies, ATA anti-topoisomerase I antibodies, BMI body mass index, CI confidence interval, CK creatin kinase, CRP C-reactive ... See full document

... These fi ndings were supported by results from a European multicenter cohort study (2002 – 2007) in which the main causes of death included pulmonary disease (35%), cardiac disease (29%), and renal failure (3%); 45 a ... See full document

... Different factors, including genetic, environment, vascular, autoimmunologic and microchimeric factors are involved in SSc pathogenesis. One theory states that antigens from the human leukocyte ... See full document

... Our understanding of the epidemiology of SSc-PAH has improved with increased precision in prevalence estimates and identification of prognostic factors. Short-term survival in SSc- PAH has improved with the ... See full document

... of systemic sclerosis (SSc) have yielded improved understanding of the complex cellular interactions that occur in this heterogeneous connective tissue ...B-cell genetic signature as ... See full document

... Most frequent findings include chronic nonprogressive proteinuria and hypertension. The most dreaded complication, scleroderma renal crisis occurs in 20% of patients. The pathogenesis involves obliterative vasculopathy ... See full document

... of Systemic Lupus Erythematosus (SLE) is complex and remains poorly ...triggers, genetic background, immunological abnormalities and environmental factors are all supposed to interact for the disease ... See full document

... chronic systemic connective tissue autoimmune disease characterized by microvascular abnormalities and pathological thickening and tethering of the skin and involvement of internal organs (gastrointestinal tract, ... See full document

... the genetic variation in two groups, the fast progressors, with a rapidly progressive and more widespread and severe disease (dcSSc patients) more likely to present an alteration in the collagenase-1 activity, and ... See full document

... The reasons for these differences are not clear. Enzyme immunoassays for the determination of endostatin were purchased from the same manufacturer (Cytimmune) and serum samples were processed in a similar way, thereby ... See full document

... growth factors, chemokines, S1P and LPA that induce fibrosis that these different cell types release would necessarily vary as such cellular infiltrates ... See full document

... profibrotic factors (eg, transforming growth factor-beta [TGF-beta] and connective tissue growth factor [CTGF]) are elevated in SSc BAL fluid and may play a role in the pathogenesis of ILD in ... See full document

... endothelial factors that have been shown to be implicated in SSc (VEGF, placenta growth factor (PlGF), sVCAM, angiopoietin-2, endoglin, endostatin, endothelin-1 and Tie-2) were mea- sured by using the quantitative ... See full document

... However, conclusions are drawn cautiously. A major concern is the difficulty in differentiating SSc- cardiomyopathy from that of IHD. Only if study populations are free of known IHD, with no or minimal risk ... See full document

... Retrospective analysis of internal organ involvement in ssSSc patients is limited, due to variety of criteria used in investigations. Some studies were based on clinically overt symptoms, while others applied more and ... See full document

... We have confirmed in a large patient cohort that COMP- C3b levels are elevated in patients with SSc compared to healthy controls. The fact that there is no difference in serum COMP-C3b between patients with dcSSc and ... See full document