[PDF] Top 20 A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication
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A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication
... of NS4B has not been resolved, although specific amino acid substitutions at I131 and other residues within this region abol- ish Con1 RNA replication ...of NS4B between Con1 and H77 ... See full document
13
A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication
... of NS4B. Moreover, as shown here (Fig. 6C), similarly to wild-type 2K-NS4B, the K8A mutant protein coprecipitated with HA-NS4A when the two proteins were coexpressed, ruling out the possibility that ... See full document
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Allelic Variation in the Hepatitis C Virus NS4B Protein Dramatically Influences RNA Replication
... Con1 NS4B enhance H77 RNA synthesis in Huh- ...Con1 NS4B protein func- tions more efficiently in the context of the H77-encoded rep- lication machinery than the native H77 ...NS4B. NS4B ... See full document
13
Functional and Physical Interaction between the Arf Activator GBF1 and Hepatitis C Virus NS3 Protein
... This interaction of GBF1 with NS3 is consistent with the crucial role of GBF1 at the onset of genome replication, since the NS3-4A protease mediates one of the earliest steps of HCV ... See full document
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Hepatitis C Virus Subgenomic Replicon Requires an Active NS3 RNA Helicase
... Hepatitis C virus (HCV) is a single-stranded positive-sense RNA virus with a ...the replication of the viral ...the NS3 protease/helicase is one of the best ...of ... See full document
8
A Hepatitis C Virus NS5A Phosphorylation Site That Regulates RNA Replication
... of replication, but the effects we observe are small, and it is therefore unlikely that serine 222 is a major regulator of RNA ...on virus production, suggesting that different serine phosphory- ... See full document
6
Evidence for a Genetic and Physical Interaction between Nonstructural Proteins NS1 and NS4B That Modulates Replication of West Nile Virus
... NS4B WT, NS1 RQ10NK plus NS4B F86C, NS1 RQ10YK plus NS4B WT, NS1 RQ10YK plus NS4B F86C, and the parent NS1 RQ (WT) plus NS4B ...plus NS4B WT or NS1 RQ10YK plus NS4B ... See full document
12
Mapping the Interactions between the NS4B and NS3 Proteins of Dengue Virus
... Flavivirus NS4B (28 kDa) is a valid target for antiviral develop- ...DENV NS4B have been identified by both academic and industry groups (20– ...of NS4B is required to support further antiviral ... See full document
13
The NS3 Helicase and NS5B-to-3′X Regions Are Important for Efficient Hepatitis C Virus Strain JFH-1 Replication in Huh7 Cells
... HCV RNA replication and virus production, and this processing may be affected by the chimeric RNA molecules between different isolates of genotype 2 as well as those be- tween genotypes ... See full document
11
NS4B Self-Interaction through Conserved C-Terminal Elements Is Required for the Establishment of Functional Hepatitis C Virus Replication Complexes
... Hepatitis C virus (HCV) is an important human pathogen, persistently infecting more than 170 million individuals ...the replication of viral RNA and the production of infectious ... See full document
14
Kissing-Loop Interaction in the 3′ End of the Hepatitis C Virus Genome Essential for RNA Replication
... our genetic study of ...for RNA replication, is of functional ...our genetic analysis are in full agree- ment with the secondary structure prediction depicted in ...two RNA elements by ... See full document
13
Association of Hepatitis C Virus Replication Complexes with Microtubules and Actin Filaments Is Dependent on the Interaction of NS3 and NS5A
... Hepatitis C virus (HCV) is a major causative agent of chronic hepatitis, liver cirrhosis, and hepatocellular ...9.6-kb RNA genome en- codes a large polyprotein ( ⬎ 3,000 amino acids), ... See full document
11
DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication
... double-stranded RNA and separate the RNA strands or might contribute to the function of HCV NS3 ...the replication of subgenomic replicon RNA was also partially suppressed in DDX3 ... See full document
5
Specific Interaction between the Hepatitis C Virus NS5B RNA Polymerase and the 3′ End of the Viral RNA
... HCV replication have been restricted by the lack of a well-estab- lished cell culture system, but studies from other positive-sense RNA viruses may provide some ...genomic RNA occurs, and ... See full document
6
Palmitoylation and Polymerization of Hepatitis C Virus NS4B Protein
... plus-strand RNA viruses induce distinct membrane alterations, which provide the necessary structural scaffold for RNA replication ...HCV RNA rep- lication complex is located on the ... See full document
11
An N-Terminal Amphipathic Helix in Hepatitis C Virus (HCV) NS4B Mediates Membrane Association, Correct Localization of Replication Complex Proteins, and HCV RNA Replication
... HCV RNA repli- cation. The preservation of an AH in the NS4B proteins of all sequenced HCV clones suggests that the interaction of NS4B’s AH with the membrane may have an important role in the ... See full document
8
Specific Interaction of Hepatitis C Virus Protease/Helicase NS3 with the 3′-Terminal Sequences of Viral Positive- and Negative-Strand RNA
... and NS3, followed by NS4A, NS4B, NS5A, and NS5B (reviewed in ref- erence ...for NS3 activity, and the central domain has been implicated as essential for this role of NS4A (3, 4, 15, 33, 34, ...HCV ... See full document
14
An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A.
... enveloped virus which contains a positive-stranded RNA ge- nome of about 9,500 nucleotides (10, 26, ...nucleocapsid C protein (21 kDa) and two putative envelope glycoproteins, E1 (37 kDa) and E2/NS1 ... See full document
9
A Hepatitis C Virus cis-Acting Replication Element Forms a Long-Range RNA-RNA Interaction with Upstream RNA Sequences in NS5B
... alternative interaction proposed ...the interaction of SL9266 sequences with the upstream region were important for ...and between the bulge loop of SL9266 and the upstream sequences rendered ... See full document
15
The Hepatitis C Virus NS3 Protein: A Model RNA Helicase and Potential Drug Target
... and replication likely occurs on the endoplasmic reticulum (Wolk et ...detected NS3 in the nucleus (Muramatsu et ...from RNA permits the helicase to unwind substrates faster (DNA is unwound faster ... See full document
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