[PDF] Top 20 Genetic polymorphism and natural selection of Duffy binding protein of Plasmodium vivax Myanmar isolates
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Genetic polymorphism and natural selection of Duffy binding protein of Plasmodium vivax Myanmar isolates
... Background: Plasmodium vivax Duffy binding protein (PvDBP) plays an essential role in erythrocyte invasion and a potential asexual blood stage vaccine candidate antigen against ... See full document
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Polymorphism patterns in Duffy binding protein among Thai Plasmodium vivax isolates
... vivax isolates. However, the rest of the allele groups that Thai isolates fell into were more related to the isolates from Korea, India, and Colombia than from Papua New Guinea (Figure ... See full document
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Genetic variability and natural selection at the ligand domain of the Duffy binding protein in brazilian Plasmodium vivax populations
... of Duffy-negative individuals infected with P. vivax emphasizes the importance of a multiva- lent vaccine strategy that, in addition to eliciting inhibi- tory antibodies, may also reduce the ability of ... See full document
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Genetic variability and natural selection at the ligand domain of the Duffy binding protein in brazilian Plasmodium vivax populations
... of Duffy-negative individuals infected with P. vivax emphasizes the importance of a multiva- lent vaccine strategy that, in addition to eliciting inhibi- tory antibodies, may also reduce the ability of ... See full document
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Genetic diversity, natural selection and haplotype grouping of Plasmodium vivax Duffy binding protein genes from eastern and western Myanmar borders
... P. vivax parasites, and it appears to have similar draw- ...in binding to the Duffy antigen within and between populations helps guide the development of a PvDBP-based ...the genetic diversity ... See full document
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Genetic polymorphism and natural selection of circumsporozoite surface protein in Plasmodium falciparum field isolates from Myanmar
... the genetic variations were mainly concentrated at these ...pressure. Natural selection analysis of global PfCSP C-terminal region suggests that this region is likely to be under natural ... See full document
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Genetic polymorphism and natural selection in the C terminal 42 kDa region of merozoite surface protein 1 among Plasmodium vivax Korean isolates
... the isolates collected in 1999 – 2000 showed only limited haplo- types which were closely related to the Belem ...among isolates collected in ...the genetic diversity of several major antigens ... See full document
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Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies
... vivax to reach clinical testing. It is therefore vital in a future CHMI efficacy study to assess whether vaccine- induced BIAbs associate with control of blood-stage parasite growth. The data obtained from this ... See full document
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Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies
... vivax to reach clinical testing. It is therefore vital in a future CHMI efficacy study to assess whether vaccine- induced BIAbs associate with control of blood-stage parasite growth. The data obtained from this ... See full document
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Population genetic structure and natural selection of apical membrane antigen 1 in Plasmodium vivax Korean isolates
... the genetic population of P. vivax circulat- ing in Korea is beneficial to knowledge of the nation- wide parasite heterogeneity and in the implementation malaria control programs in the ...on genetic ... See full document
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Population genetic structure and natural selection of Plasmodium falciparum apical membrane antigen 1 in Myanmar isolates
... Conclusions: Myanmar PfAMA‑1 showed similar patterns of nucleotide diversity and amino acid polymorphisms compared to those of global ...Balancing natural selection and intragenic recombination ... See full document
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Genetic polymorphism of merozoite surface protein 1 and merozoite surface protein 2 in Plasmodium falciparum field isolates from Myanmar
... in Myanmar patients are needed to evaluate the impact of this polymorphism on the immune response to the antigens, since the genetic diversity would not necessarily reflect selection acting at ... See full document
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Genetic diversity, haplotypes and allele groups of Duffy binding protein (PkDBPαII) of Plasmodium knowlesi clinical isolates from Peninsular Malaysia
... the genetic diver- sity and natural selection of PkDBP α ...of genetic diversity was ob- served, the PkDBP α II appeared to be under purifying (negative) ... See full document
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Distinct genetic difference between the Duffy binding protein (PkDBPαII) of Plasmodium knowlesi clinical isolates from North Borneo and Peninsular Malaysia
... P. vivax PVDBPII is highly diverse, and in some instances within a population of a particular region ...the protein, therefore may serve as a mechanism of immune evasion for the ...the binding site ... See full document
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Exploration of genetic diversity of Plasmodium vivax circumsporozoite protein (Pvcsp) and Plasmodium vivax sexual stage antigen (Pvs25) among North Indian isolates
... of polymorphism has been reported among malarial antigens which are under selection pressure imposed by host ...stage-specific genetic diversity among Plasmodium vivax candidate genes ... See full document
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Limited genetic diversity in the PvK12 Kelch protein in Plasmodium vivax isolates from Southeast Asia
... population genetic diversity of PvK12 Tajima’s D test performed on 473 PvK12 sequences obtained in the world did not detect potential natural selection on this gene (Table ...In isolates from ... See full document
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Molecular Genetic Characterization of the Merozoite Surface Protein 1 Gene of Plasmodium vivax from Reemerging Korean Isolates
... Korean isolates seem to share some molecular similarity with previously characterized Solo- mon Islands isolates and several Philippine ...Korean isolates apparently represent a distinct genotypic ... See full document
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Single-Chain Antibody Fragment Specific for Plasmodium vivax Duffy Binding Protein
... To evaluate the biological effects of anti-PvRII scFvs, region II of PvDBP was expressed on the surface of COS-7 cells in the form of an enhanced green fluorescent protein (EGFP) fusion protein. Following ... See full document
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Immunogenicity of a Synthetic Vaccine Based on Plasmodium vivax Duffy Binding Protein Region II
... Duffy Binding Protein Region II Francis ...in Plasmodium merozoite invasion of host red blood cells represent attractive targets for blood-stage vaccine development against ...In ... See full document
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Genetic diversity among Plasmodium vivax isolates along the Thai–Myanmar border of Thailand
... P. vivax isolates presented here were high despite the low levels of malaria ...P. vivax strains in Southeast Asia region are predicted to have a high relapse incidence (836 relapses per 100,000 ... See full document
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