[PDF] Top 20 Genetic variants associated with lung function: the long life family study
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Genetic variants associated with lung function: the long life family study
... identified variants in this study may include limited power, population specific genetic heterogeneity and differences in environmental exposures such as ...smoking. Genetic het- erogeneity in ... See full document
9
Genetic variants in lncRNA HOTAIR are associated with lung cancer susceptibility in a Chinese Han population in China: a case–control study
... with lung cancer ...developing lung cancer, and in stratified analyses for pathologic type of lung cancer, sex, and smoking status, the associations between rs4759314 polymorphism and lung ... See full document
10
Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study
... multi-center family-based cohort study, enrolled 4,953 individuals from 539 families clustered for exceptional survival to identify environ- mental and genetic factors that account for the ... See full document
12
Germline Missense Variants in BRCA1 : New Trends and Challenges for Clinical Annotation
... Abstract: Genetic testing allows for identification of germline DNA variations which are associated with a significant increase in risk of developing breast and ovarian ...BRCA2 variants according to ... See full document
13
Genetic variants affecting cross sectional lung function in adults show little or no effect on longitudinal lung function decline
... regions associated with lung function measured at a single point in time (ie, cross-sectional lung ...The lung function attained at a given time point in adult- hood will be in fl ... See full document
10
Large scale genome wide analysis identifies genetic variants associated with cardiac structure and function
... Heart, Lung, and Blood Institute (N01-HL-25195; R01HL 093328 to RSV), a MAI- FOR grant from the University Medical Center Mainz, Germany (to PSW), the Center for Translational Vascular Biology (CTVB) of the ... See full document
16
Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers
... the genetic study, and the research protocol was reviewed and approved by the institutional review boards at Wake For- est University and Saint Louis ...pulmonary function testing were ...and ... See full document
9
Genetic variants associated with Crohn's disease
... This life-long disease commonly presents with abdominal pain, diarrhea, vomiting, and weight ...The study of genetic variants associated with Crohn’s disease has shed light on ... See full document
8
Targeted sequencing of lung function loci in chronic obstructive pulmonary disease cases and controls
... but genetic factors are also relevant contrib- ...the lung function measures used in the diagnosis of COPD have identified a number of loci, however association signals are often broad and ... See full document
17
Genetic variants in ADAM33 are associated with airway inflammation and lung function in COPD
... our study also identified the relationship between SNP and TLCO of COPD since TLCO associated with the severity of ...were associated with de- creased TLCO of COPD, suggesting that the ADAM33 also ... See full document
10
Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case–control study in Shanghai, China
... our study should also be ...the study population, 43 but we did take into consideration the par- ticipants ’ history of hepatitis and liver ...homozygous variants were low in subgroups and therefore ... See full document
8
Genetic variants in FAM13A and IREB2 are associated with the susceptibility to COPD in a Chinese rural population: a case-control study
... and family history of pulmonary diseases) were used to estimate the odds ratio (OR) and 95% confidence interval (95% CI) for evaluating the effect of each SNP on COPD ...Then, genetic variants were ... See full document
11
The Genetic Overlap Between Hair and Eye Color
... gene variants present in the melanin pathway, including HERC2/OCA2, SLC24A4, and TYR (Candille et ...all genetic variance in hair and eye ...the genetic correlation between hair and eye color for ... See full document
5
High risk for lung and bladder cancers in the Arabian Gulf population associated with EGFR genetic variants regulating expression
... EGFR expression in cancer pathophysiology suggest that the success of immunotherapy using antibodies against EGFR depends heavily on a good assessment of EGFR expression. Standardized IHC protocols, with harmonized ... See full document
7
Genomic-based tools for the risk assessment, management, and prevention of type 2 diabetes
... Genetic factors play a substantial role in the risk, onset, severity, and downstream complications of T2D. Overall, current knowledge about the contribution of genomic fac- tors to T2D reinforces the concept that ... See full document
8
Absence of history of oral cleft in first-degree relatives of patients with prostate cancer
... with NSCL/P, chi-square and Fisher’s exact test and odds ratio (OR) with its 95% confidence interval (95% CI) for risk magnitude assessment. Values with p<0.05 were considered statistically significant. Results: Of ... See full document
6
Prediction models for the development of COPD: a systematic review
... The clinical usefulness of a model requires the determi- nation of positive and negative likelihood ratios in order to determine the ability to rule in COPD versus ruling it out. The positive and negative likelihood ... See full document
9
<em>Cytochrome</em> <em>P450 3A4*22</em>, <em>PPAR-α</em>, and <em>ARNT</em> polymorphisms and clopidogrel response
... not associated with altered clopidogrel response. While our study included only a limited number of carriers of the CYP3A4*22 variant, it is unlikely that a significantly reduced clopidogrel response could ... See full document
8
<p>Identification of genetic variants associated with skeletal muscle function deficit in childhood acute lymphoblastic leukemia survivors</p>
... common variants after correction for multiple testing in WES dataset is ...novel variants asso- ciated with genetic predictability of skeletal muscle de fi cit in the targeted ...common ... See full document
13
Association of genetic loci for migraine susceptibility in the she people of China
... common genetic variants were identified that are associated with migraine susceptibility through twin, family clustering, and genome wide association studies of patients with migraine (with ... See full document
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