[PDF] Top 20 Genome wide expression profiles of subchondral bone in osteoarthritis
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Genome wide expression profiles of subchondral bone in osteoarthritis
... the bone parameters and OPG to RANKL ratios, comparing LT with non-OA we con- cluded that the bone gene expression patterns of OA LT regions were consistent with an early-stage OA ...increases ... See full document
12
Original Article Subchondral bone changes and chondrogenic capacity of progenitor cells from subchondral bone in the collagenase-induced temporomandibular joints osteoarthritis rabbit model
... characterize subchondral bone changes, and to determine bio- logical activity characteristics of progenitor cell populations from subchondral bone in the collagenase-induced temporomandibular ... See full document
8
Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis
... by wide-ranging tissue damage and ultimate biomechanical failure of the whole ...of bone-resident mesenchymal stem cells (MSCs) in these bone remodeling responses, and a proposal that targeting MSC ... See full document
12
Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis
... the osteoarthritis trigger had been ...decreased subchondral cortical ...in osteoarthritis and adds to the concept of the involve- ment of bone, specifically the subchondral bone ... See full document
12
Quantitative evaluation of subchondral bone microarchitecture in knee osteoarthritis using 3T MRI
... human osteoarthritis studies, most studies have focused on end-stage subchondral bone changes, and these results were mainly derived from ana- lyses of tibia plateaus after joint replacement using ... See full document
9
Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
... and bone sclerosis are the most consistently observed characteristics of osteoarthritis ...and subchondral bone remodeling during disease progres- sion, we developed a consistent and reliable ... See full document
14
Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
... the subchondral plate and osteophytosis during knee OA in humans [14-16,18] and animals ...of subchondral bone volume in OA patients with hip and knee compromise ...increased subchondral ... See full document
11
Investigation of Subchondral Bone Abnormalities associated with Osteoarthritis using Image-Based Biomechanics
... homogeneous bone modulus (or rigid body) that lead to over or underestimations of values in both the bone and soft tissues when comparing the exact 3D location in the heterogeneous FE model (Figure ...of ... See full document
123
Tibial subchondral bone size and knee cartilage defects: relevance to knee osteoarthritis
... ral bone becomes irregular (Figure 2 B, baseline), so we also included this in the classification system (7, ...that subchondral bone expansion plays an important role in the etiology of defects (7, ... See full document
23
Effect of Vitamin D supplementation on synovial tissue volume and subchondral bone marrow lesion volume in symptomatic knee osteoarthritis
... Methods: Data was acquired from participants who took part in a randomised placebo-controlled trial (UK VIDEO) investigating the effect of vitamin D therapy (800 IU cholecalciferol daily) on radiographic joint space ... See full document
7
Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis
... the expression of specific chemokines such as chemokine (C-C motif ) lig- and (CCL)−2,−3,−4,−5 and−9 have been found to be highly expressed by FBGCs in comparison to osteoclasts ...in bone, LGC and FBGC are ... See full document
10
Subchondral bone abnormalities in knee osteoarthritis
... Our study found that MRI-OPs and established-OPs are associated with knee structural changes in a dose response manner. Cross-sectional studies suggested that greater size of MRI-detected OPs correlated with higher ... See full document
194
Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes
... damage subchondral plate and calcified cartilage, facilitating more biochem- ical catabolic molecule transportation between subchon- dral bone and ...the subchondral plate and calcified cartilage, ... See full document
12
Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
... cate that osteoclasts in aberrant subchondral bone remodeling could be an important origin of OA pain. The various methods used to measure pain in this study are complementary. We exam- ined mechanical ... See full document
19
The role of subchondral bone in osteoarthritis
... The work in this thesis was conducted as part of the TASOAC study, an ongoing prospective, population-based study aimed at identifying the environmental, genetic, and biochemical factors associated with the development ... See full document
194
Knee osteoarthritis patients with more subchondral cysts have altered tibial subchondral bone mineral density
... Subchondral cysts are associated with higher localized stress [4], which could stimulate bone remodelling or bone alterations. Ex vivo studies at both the hip using high-resolution computed ... See full document
9
Original Article Accelerated development of instability-induced osteoarthritis in transgenic mice overexpressing SOST
... regulating bone homestasis, and has also been linked to osteoarthritis (OA) ...Methods: Bone and cartilage phenotypes of SOST Tg mice at 10 weeks of age were investi- gated by dual x-ray ... See full document
13
Correlation between μCT imaging, histology and functional capacity of the osteoarthritic knee in the rat model of osteoarthritis
... the subchondral bone at the medial tibial plateau, the lengths of tibial plateau for the sham and MMT rats were measured to average ...dral bone and ...and subchondral bone to always be ... See full document
12
Extracorporeal shockwave therapy shows a number of treatment related chondroprotective effect in osteoarthritis of the knee in rats
... chondral bone of proximal tibia and distal femur were ...The subchondral bone remodeling was evaluated with tissue distributions including cortical bone, cancellous bone and fibrous ... See full document
8
Investigation of naturally occurring osteoarthritis in the metacarpophalangeal joints of wild horses : a thesis presented in partial fulfilment of the requirements for the degree of Master of Veterinary Science at Massey University
... 4.9.2 Conclusions This study demonstrates that changes consistent with osteoarthritis, such as articular cartilage fibrillation, wear lines, subchondral bone sclerosis, osteophytosis and[r] ... See full document
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