[PDF] Top 20 Heptad Repeat 2 in Herpes Simplex Virus 1 gH Interacts with Heptad Repeat 1 and Is Critical for Virus Entry and Fusion
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Heptad Repeat 2 in Herpes Simplex Virus 1 gH Interacts with Heptad Repeat 1 and Is Critical for Virus Entry and Fusion
... Herpes simplex virus 1 (HSV-1) entry into cells and cell-cell fusion mediated by HSV-1 glycoproteins require four glycoproteins, gD, gB, gH, ...these, ... See full document
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Substitution of Herpes Simplex Virus 1 Entry Glycoproteins with Those of Saimiriine Herpesvirus 1 Reveals a gD-gH/gL Functional Interaction and a Region within the gD Profusion Domain That Is Critical for Fusion
... SaHV-1 gH/gL and gB, fusion was retained for all of the constructs except pQF124, the FIG 1 Expression of entry glycoproteins from HSV-1 and ...FLAG-tagged gH, gH ... See full document
13
Hydrophobic α-Helices 1 and 2 of Herpes Simplex Virus gH Interact with Lipids, and Their Mimetic Peptides Enhance Virus Infection and Fusion
... of herpes simplex virus into cells occurs by fusion and requires four ...glycoproteins, gH carries structural and functional elements typical of class 1 fusion ... See full document
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Characterization of Vesicular Stomatitis Virus Pseudotypes Bearing Essential Entry Glycoproteins gB, gD, gH, and gL of Herpes Simplex Virus 1
... neutralizes virus infec- tivity, inhibits cell-cell spread (36), and blocks cell-cell fusion of cells transiently expressing the four entry glycoproteins ...between gH/gL and gB (21), which ... See full document
8
Mutations of Glu560 within HIV 1 Envelope Glycoprotein N terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry
... C‑terminal heptad repeat regions (HR1 and HR2, respectively) of gp41 can inhibit HIV‑1 infection in a dominant negative manner by interfering with refolding of the viral HR1 and HR2 to form a ... See full document
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Interplay between the Herpes Simplex Virus 1 gB Cytodomain and the gH Cytotail during Cell-Cell Fusion
... Herpesvirus entry into cells is mediated by the viral fusogen gB, which is thought to refold from the prefusion to the postfusion form in a series of large conformational changes that energetically couple ... See full document
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Coronavirus Escape from Heptad Repeat 2 (HR2)-Derived Peptide Entry Inhibition as a Result of Mutations in the HR1 Domain of the Spike Fusion Protein
... peptide entry inhibitor, we passaged a recombinant mouse hepatitis virus (MHV; strain A59) express- ing a Renilla luciferase reporter gene (MHV-ERLM) (3) in quadruplicate on LR7 cells at a high multiplicity ... See full document
6
Peptides Corresponding to the Heptad Repeat Motifs in the Transmembrane Protein (gp41) of Human Immunodeficiency Virus Type 1 Elicit Antibodies to Receptor-Activated Conformations of the Envelope Glycoprotein
... ficiency virus type 1 (HIV-1) mediates virus entry by fusing viral and cellular membranes, resulting in delivery of the viral nucleocapsid to the cell ...membrane fusion activity ... See full document
5
Extended Synaptotagmin 1 Interacts with Herpes Simplex Virus 1 Glycoprotein M and Negatively Modulates Virus-Induced Membrane Fusion
... own fusion machinery, whether a single protein, such as the vesicular stomatitis virus G glycopro- tein, or multiple viral proteins, as for herpesviruses (20, ...its fusion activities across cellular ... See full document
19
Conserved Salt Bridge between the N- and C-Terminal Heptad Repeat Regions of the Human Immunodeficiency Virus Type 1 gp41 Core Structure Is Critical for Virus Entry and Inhibition
... immunodeficiency virus gp41 also formed similar six-helix bundle structure in solution ...the fusion-active conformation of HIV-1 envelope, which brings the viral and cellular membranes into close ... See full document
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A New Class of Receptor for Herpes Simplex Virus Has Heptad Repeat Motifs That Are Common to Membrane Fusion Proteins
... HSV entry at membrane ...viral entry or cell fusion proteins (5, 13, 16, 17, 28, 31), we hypothesize that the pre- dicted B5 C-terminal coiled coil may engage those found in an essential HSV ... See full document
12
Insertional Mutations in Herpes Simplex Virus Type 1 gL Identify Functional Domains for Association with gH and for Membrane Fusion
... type 1 (HSV-1) gB suggests that it is a class III viral fusogen similar in domain organiza- tion, but not primary sequence, to the G protein of vesicular stomatitis virus ...HSV-1 gH ... See full document
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A Heptad Repeat in Herpes Simplex Virus 1 gH, Located Downstream of the α-Helix with Attributes of a Fusion Peptide, Is Critical for Virus Entry and Fusion
... viral fusion glycoproteins are the fusion peptide and the coiled-coil bun- dles of ...The fusion peptide is a hydrophobic ␣ -helix able to penetrate the membrane of the target cell; it may be located ... See full document
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Six helix bundle completion in the distal C terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection
... 3 Fusion assay of alanine insertion mutants of ...at 2 h after coculture to examine the fusion activities of ...the fusion activity measured by the DSP assay (open bar) was normalized to the ... See full document
11
Mutations of Gln64 in the HIV-1 gp41 N-Terminal Heptad Repeat Render Viruses Resistant to Peptide HIV Fusion Inhibitors Targeting the gp41 Pocket
... HIV-1 fusion by interacting with the viral gp41 NHR trimer ...HIV fusion inhibitor to be licensed by the ...mainly interacts with this region in ... See full document
5
Sensitivity of Human Immunodeficiency Virus Type 1 to Fusion Inhibitors Targeted to the gp41 First Heptad Repeat Involves Distinct Regions of gp41 and Is Consistently Modulated by gp120 Interactions with the Coreceptor
... to fusion inhibitors, possibly neu- tralizing the differences seen between the sensitivity of CXCR4 versus CCR5 ...to fusion inhibitors T-20 and T-1249 by using a cMAGI-MAGI cell-based assay ...to ... See full document
10
Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion.
... 2596-2604 0022-538X/88/082596-09$02.00/0 Copyright C 1988, American Society for Microbiology Role of Glycoprotein B of Herpes Simplex Virus Type Entry and Cell Fusion 1 in Viral WEIZHONG[r] ... See full document
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Recombination Analysis of Herpes Simplex Virus 1 Reveals a Bias toward GC Content and the Inverted Repeat Regions
... Herpes simplex virus 1 (HSV-1) causes recurrent mucocutaneous ulcers and is the leading cause of infectious blindness and spo- radic encephalitis in the United ... See full document
10
Recombination of the internal direct repeat element DR2 responsible for the fluidity of the a sequence of herpes simplex virus type 1.
... Short, duplicated sequence indicative of the recombinogenicity of the junction between a unique and an inverted repeat sequence in the S component of the herpes simplex virus type 1 geno[r] ... See full document
7
Sequence requirements for DNA rearrangements induced by the terminal repeat of herpes simplex virus type 1 KOS DNA.
... If the recombination event that gave rise to the inversion fragment occurred by cleavage-ligation at the position of site-specific cleavage directed by pacl case 1, then the 5'-flanking [r] ... See full document
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