[PDF] Top 20 Herpes Simplex Virus ICP0 Mutants Are Hypersensitive to Interferon
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Herpes Simplex Virus ICP0 Mutants Are Hypersensitive to Interferon
... of ICP0 mutants revealed above stems at least in part from a failure to accumulate adequate quantities of IE ...and ICP0 mutants (1, ...infecting virus, although in1814, n212, and ... See full document
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Herpes Simplex Virus Type 1 Regulatory Protein ICP0 Aids Infection in Cells with a Preinduced Interferon Response but Does Not Impede Interferon-Induced Gene Induction
... of ICP0 (Fig. 1B). Therefore, ICP0 does not interfere with any step of the path- way leading from IFN engagement with its receptor at the cell surface through to synthesis of a representative ...whether ... See full document
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Phosphorylation Site Mutations Affect Herpes Simplex Virus Type 1 ICP0 Function
... affect ICP0’s subcellular and subnuclear localization (Phos 3), ND10-dis- rupting activity in a subset of cells (Phos 2 and 3), and trans- activating activity (Phos 1 and 3) in Vero ...of ICP0, only the ... See full document
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The Herpes Simplex Virus Immediate-Early Ubiquitin Ligase ICP0 Induces Degradation of the ICP0 Repressor Protein E2FBP1
... of herpes simplex virus 1 (HSV-1). ICP0 is an immediate-early (IE) protein of HSV-1 that exhibits multiple functions, including transcrip- tional activation and herpes ubiquitin ligase ... See full document
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Recruitment of Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 to the Virus Particle
... ⌬ ICP0 mutant virus dl1403, and ICP0 and VP22 levels were compared to that present in Wt (s17) ...⌬ ICP0 mutant virus indicated that VP22 packag- ing was not dependent on ICP0 ... See full document
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Optimized Viral Dose and Transient Immunosuppression Enable Herpes Simplex Virus ICP0-Null Mutants To Establish Wild-Type Levels of Latency In Vivo
... of ICP0 mutants in mouse eyes and viral genome loads in latently infected ...HSV-1 ICP0- null mutants replicate poorly in mice and rabbits (14, 28) and establish latency much less efficiently ... See full document
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Activities of ICP0 Involved in the Reversal of Silencing of Quiescent Herpes Simplex Virus 1
... various mutants to form plaques on L7 and Vero cells provides a relative measure of the defects caused by the various mutations in ...finger mutants (RF and RFBac) displayed a 30- to 60-fold reduction in ... See full document
10
Complementation of a Herpes Simplex Virus ICP0 Null Mutant by Varicella-Zoster Virus ORF61p
... The herpes simplex virus (HSV) ICP0 protein acts to overcome intrinsic cellular defenses that repress viral ␣ gene ...in ICP0’s RING finger or are deleted for the gene are sensitive to ... See full document
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Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture.
... These mutants contain wild-type copies of ICPO yet fail to express early and Of the three major kinetic classes of genes of herpes simplex virus type 1 HSV-1, the immediate-early a genes[r] ... See full document
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Interaction of Herpes Simplex Virus ICP0 with ND10 Bodies: a Sequential Process of Adhesion, Fusion, and Retention
... of ICP0 gene structure and ICP0 mutants used in this ...of ICP0 in the terminal and internal repeats and expanded illustration of ICP0 gene, with three exons and two ...3, ICP0 ... See full document
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Herpes Simplex Virus Immediate-Early Protein ICP0 Is Targeted by SIAH-1 for Proteasomal Degradation
... the ICP0-negative dl1403 mutant (HSV-1 ⌬ ICP0) (26) were provided by Roger ...⌬ ICP0 in U2OS ...of virus to allow attachment of virions followed by washing and incubation at 37°C for different ... See full document
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A Pre-Immediate-Early Role for Tegument ICP0 in the Proteasome-Dependent Entry of Herpes Simplex Virus
... Herpes simplex virus (HSV) entry requires host cell 26S proteasomal degradation activity at a postpenetra- tion ...protein ICP0 has E3 ubiquitin ligase activity and interacts with the ...to ... See full document
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ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
... wild-type herpes simplex virus type 1 (HSV-1), ICP0-null mutant viruses reactivate inefficiently from explanted, latently infected mouse trigeminal ganglia (TG), indicating that ICP0 is ... See full document
10
Perturbation of Cell Cycle Progression and Cellular Gene Expression as a Function of Herpes Simplex Virus ICP0
... of ICP0 expression may play a role in the suc- cessful completion of the viral replication ...simian virus 40, and human papillomavirus, which require cellular DNA replication pro- teins for viral ... See full document
11
Processing of α-Globin and ICP0 mRNA in Cells Infected with Herpes Simplex Virus Type 1 ICP27 Mutants
... 1. Mutants d27-1, n59R, n263R, n406R, and n504R (42, 45), d1-2 (44), d3-4 and d4-5 (31), and M11, M15, and M16 (43) have been described ...This virus produces a truncated ICP27 protein that reacts with ... See full document
13
Herpes Simplex Virus Type 1 ICP0 Phosphorylation Mutants Impair the E3 Ubiquitin Ligase Activity of ICP0 in a Cell Type-Dependent Manner
... Phos mutants. (i) De novo virus synthesis from infectious viral ...that ICP0 significantly enhances the pro- duction of new viral particles as part of this ...Phos mutants, viral DNAs from wt ... See full document
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Herpes Simplex Virus 1 ICP0 Phosphorylation Site Mutants Are Attenuated for Viral Replication and Impaired for Explant-Induced Reactivation
... of ICP0 functional domains, phosphorylation sites, and phosphorylation site ...of ICP0 and the locations of its major functional ...of ICP0 phosphorylation are indicated by bars below its ... See full document
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Expression of Herpes Simplex Virus ICP0 Inhibits the Induction of Interferon-Stimulated Genes by Viral Infection
... induced interferon-stimulated genes very similar to other non-IE-expressing mutants, including in1312, used by Nicholl et ...50). Interferon-stimulated gene expression increased with increas- ing ... See full document
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Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0.
... Regulation of the herpes simplex virus type 1 late gamma2 glycoprotein C gene: sequences between base pairs -34 to +29 control transient expression and responsiveness to transactivation [r] ... See full document
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Multimerization of ICP0, a herpes simplex virus immediate-early protein.
... To determine whether any of the transactivation-deficient IE-0 mutants that we isolated displayed a dominant negative phenotype, Vero cells were cotransfected with equimolar amounts of a[r] ... See full document
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