[PDF] Top 20 Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells.
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Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells.
... To examine the role of ICPO in the regulation of viral gene expression during productive infection, we characterized the wild-type virus, an ICPO null mutant 7134, and several ICPO nonse[r] ... See full document
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Long-Term Transgene Expression in Mice Infected with a Herpes Simplex Virus Type 1 Mutant Severely Impaired for Immediate-Early Gene Expression
... are infected with HSV-1 in the presence of acyclovir to prevent virus ...many cells express LATs (50, 63, ...and virus replication rapidly resumes (51, 63, 64, ...and/or ICP0 ... See full document
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Processing of α-Globin and ICP0 mRNA in Cells Infected with Herpes Simplex Virus Type 1 ICP27 Mutants
... Poly(A) tail extension by certain mutant forms of ICP27. The observation that certain mutant forms of ICP27 cause a significant change in the heterogeneity in length of the ␣-glo- bin mRNA poly(A) tail was surprising and ... See full document
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Immature Monocyte-Derived Dendritic Cells Are Productively Infected with Herpes Simplex Virus Type 1
... Herpes simplex viruses (HSV) have developed several immunoevasive ...HSV type 1 may interfere with the immune response through infection of immature dendritic cells (DC) and selective ... See full document
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Overexpression of the herpes simplex virus type 1 immediate-early regulatory protein, ICP27, is responsible for the aberrant localization of ICP0 and mutant forms of ICP4 in ICP4 mutant virus-infected cells.
... of cells cotransfected with plasmids expressing ICP0 and mutant forms of ICP4, in which the staining pattern of ICP0 was not changed in the presence of mutant ICP4 ...of cells infected ... See full document
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ICP0 Gene Expression Is a Herpes Simplex Virus Type 1 Apoptotic Trigger
... Human herpes simplex virus type 1 (HSV-1) is a large DNA virus (25) whose infection is characterized by the establishment of latency in neuronal cells (60) and the ... See full document
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Transcriptional Coactivators Are Not Required for Herpes Simplex Virus Type 1 Immediate-Early Gene Expression In Vitro
... gene expression is not impaired in SiHa cells but is augmented in the presence of wild-type ...SiHa cells were infected with HSV-1 strain KOS at an MOI of 1 ...SiHa ... See full document
14
ICP0 Prevents RNase L-Independent rRNA Cleavage in Herpes Simplex Virus Type 1-Infected Cells
... by immediate early response factors and are thus activated at early times of ...at late times of ...than ICP0 assist in blocking this cellular antiviral ...only ICP0 activity is ... See full document
8
Neurons Differentially Activate the Herpes Simplex Virus Type 1 Immediate-Early Gene ICP0 and ICP27 Promoters in Transgenic Mice
... Herpes simplex virus type 1 (HSV-1) immediate-early (IE) proteins are required for the expression of viral early and late ...regulate ... See full document
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Accumulation of Herpes Simplex Virus Type 1 Early and Leaky-Late Proteins Correlates with Apoptosis Prevention in Infected Human HEp-2 Cells
... Vero cells have the distinction of being unable to undergo apoptosis following ICP27-null virus infection ...Thus, virus growth in Vero cells is an ideal assay to assess the consequences of ... See full document
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The Herpes Simplex Virus Immediate-Early Ubiquitin Ligase ICP0 Induces Degradation of the ICP0 Repressor Protein E2FBP1
... is infected cellular protein 0 (ICP0) of herpes simplex virus 1 ...(HSV-1). ICP0 is an immediate-early (IE) protein of HSV-1 that exhibits ... See full document
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Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins
... the expression of specific sets of IE ...on cells infected with the multiple IE mutants. This type of experiment predominantly limits viral gene expression to that of the IE ...ICP27. ... See full document
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A Pre-Immediate-Early Role for Tegument ICP0 in the Proteasome-Dependent Entry of Herpes Simplex Virus
... gene expression, 17 ⫹ was inhibited to a similar extent by MG132 at MOIs ranging from ...as ICP0 is present. The level of input ICP0 may not affect the requirement of the ...proteasome. ... See full document
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Recruitment of Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 to the Virus Particle
... before ICP0 translocates into the cytoplasm (21, ...a late gene product(s), as inhibition of DNA synthesis results in nu- clear retention of ICP0 ...of ICP0 to translocate in this ICP27- ... See full document
15
Induction of Cellular Stress Overcomes the Requirement of Herpes Simplex Virus Type 1 for Immediate-Early Protein ICP0 and Reactivates Expression from Quiescent Viral Genomes
... most cells contain a quiescent HSV-1 genome ...U2-OS cells demonstrated that the nonpermissive phenotype is dom- inant, demonstrating the existence of cellular factors that ac- tively repress the ... See full document
9
Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate-early protein synthesis.
... of cells support lytic infection, and at high MOI, in1814 replicates in all cells of a culture as efficiently as wild-type HSV-1, presumably because adequate amounts of IE mRNAs and proteins ... See full document
7
Reactivation of Expression from Quiescent Herpes Simplex Virus Type 1 Genomes in the Absence of Immediate-Early Protein ICP0
... Gene expression during coinfection and ...during ICP0-null infections, some viral genomes failed to replicate even in cells supporting active virus ...gene expression. HFFF2 ... See full document
9
Binding of ICP4, TATA-Binding Protein, and RNA Polymerase II to Herpes Simplex Virus Type 1 Immediate-Early, Early, and Late Promoters in Virus-Infected Cells
... IE genes and very low or undetectable levels of E and L gene ...E genes are acti- vated, IE genes are repressed, but true L genes are not ... See full document
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Differential Role of Sp100 Isoforms in Interferon-Mediated Repression of Herpes Simplex Virus Type 1 Immediate-Early Protein Expression
... (35). ICP0 is necessary to pre- vent IFN-  from silencing HSV-1 IE gene expression (20, 38), in part by counteracting an IFN-induced block to virus tran- scription ...IE genes, whereas ... See full document
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The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27.
... L7 cells. L7 cells supply complementing levels of ...of ICP0 to the levels of transcript accumulation by providing ICP0 from two different ...by ICP0 at the level of transcription ... See full document
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