[PDF] Top 20 High-level hepatitis B virus replication in transgenic mice.

... Hepatitis B virus (HBV) transgenic mice whose hepatocytes replicate the virus at levels comparable to that in the infected livers of patients with chronic hepatitis have ... See full document

... HBV transgenic mice before and after the adoptive transfer of HBV-specific CTLs or infection with LCMV, which inhibit HBV replication by IFN-␥- and IFN-␣/ ␤-dependent mechanisms, ...HBV ... See full document

... Chronic hepatitis delta (CHD) is a serious cause of viral hepatitis throughout the world, with high morbidity and mortality rates ...by hepatitis delta virus ...of hepatitis ... See full document

... Plasmid construction. All DNA manipulations were performed by standard techniques (41), unless otherwise noted. For both liver- and non-liver-specific expression of HDV genomic RNA, head-to-tail cDNA dimers of HDV RNA ... See full document

... chronic hepatitis B infection for more than 2 decades, yet the mechanism of action of this antiviral remains poorly ...anti-hepatitis B virus (HBV) activity are upregu- lated by type I ... See full document

... the B-cell ...influenza virus (5) and hepatitis C virus (1) and the antigens of several cancers, including melanoma (17, 29), have been described ... See full document

... HBV replication (38, ...viral replication. However, a high proportion of hepatocyte nuclei remained HBcAg ...wild-type mice receiving the same ...HBVTg mice and a strong antiviral ... See full document

... elevated level of circulating viral antigen ...viral replication in the female HBV transgenic mice ...male mice may simply reflect the limited effect fasting has on viral ... See full document

... HBV replication in cell cultures ...the replication of this HBV ARE mutant ...the replication of wild-type HBV and the ARE mutant in ...naïve mice were sham operated on or castrated and ... See full document

... Ab (500 ␮ g) was also delivered intraperitoneally to one group of animals 24 h prior to VSV-MS infection, and mice were euthanized 7 days postinfection. (A) Total hepatic DNA was analyzed for HBV ... See full document

... HBV transgenic mice treated with these PPAR␣ ...HBV transgenic mice in response to peroxisome proliferators, a dramatic PPAR␣-dependent increase in viral replication intermediates is ... See full document

... Hepatitis B virus (HBV) is a hepatotropic, noncytopathic DNA virus that causes acute and chronic necroinflammatory liver disease and hepatocellular carcinoma ...HBV replication in ... See full document

... ATX mice and the identification of mutation hot spots may have important physiological ...is high (5, 19) and in AFB1-treated human cells ex- pressing HBx ...the mice used in this study (both AFB1 ... See full document

... Hepatitis B virus (HBV) infection occurs world- wide, especially in southeastern Asia and ...chronic hepatitis, cirrhosis and even liver cancer. In addition, the hepatitis B ... See full document

... Chronic hepatitis B virus (HBV) infection can lead to liver cirrhosis and hepatocellular ...the virus results in the selection of escape mutants and viral ...HBV replication-competent ... See full document

... Tg38 mice carried the X-null HBV ...HBV transgenic mice with ...expression level of SOCS3 in control mice, but it was not able to do so in Tg05 and Tg38 mice and, on the ... See full document

... low level of mutations in- curred by mouse hepatocyte DNA under the conditions used for the present study was the result of oxidative metabolism and ...using mice treated with hepatocarcinogens are now in ... See full document

... immunodeficiency virus (20), encephalomyocardarditis virus (EMCV) (18), and vac- cinia virus ...the hepatitis C virus NS5 and E2 proteins and PKR was suggested to reduce the sensitivity ... See full document

... Table 1, Table 2 gives the derivation of the significant ( p = .001) DCP Effects Model (DCP-EM) variable cluster from the linear multivariate stepwise regression of DCP dosage versus all the viral, IDO, and ... See full document

... mtTg04/X mice were analyzed, the mtTg04 mice had a slightly lower viral titer than the mtTg04/X mice at the age of 6 ...mtTg04 mice had a viral titer that was approximately fourfold lower than ... See full document