[PDF] Top 20 Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation.
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Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation.
... to cell cycle progression in T cells (39, ...nef1/2). nef was either left intact or exchanged for a nef double mutant con- taining a start codon deletion and premature termination codon midway ... See full document
12
Nef-Mediated Resistance of Human Immunodeficiency Virus Type 1 to Antiviral Cytotoxic T Lymphocytes
... of nef on the immunogenicity and pathoge- nicity of HIV-1 infection suggests that this gene could be a target for enhancing cellular immunity in chronically infected individuals or the design of ... See full document
6
Virus-Specific Cytotoxic T Lymphocytes in Human Immunodeficiency Virus Type 1-Infected Chimpanzees
... with human HIV-1-specific ...optimal antigen-spe- cific stimulation was needed to expand these cell populations to a detectable level suggests that the frequencies of ... See full document
5
Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection
... subjects’ T cells recognized the highest ranking peptides, and few recognized the low-ranking ...contain T-cell ...of T-cell response with the PTE peptide set than with the CON set, the ... See full document
13
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis.
... Does Nef act directly or indirectly? The infectivity of a virus expressing a nonmyristoylated form of the protein is as im- paired as that of a nef-deleted ...virus. Nef must ... See full document
9
Leucine-Specific, Functional Interactions between Human Immunodeficiency Virus Type 1 Nef and Adaptor Protein Complexes
... The Nef protein containing the SDYQRL sequence was studied because it bound well to 1 in the yeast two-hybrid assay yet was devoid of biologic ...protein, Nef-SDYQRL bound inef- ficiently to intact ... See full document
13
Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein.
... Type 1 human immunodeficiency viruses encoding mutated nef reading frames are 10- to 30-fold less infectious than are isogenic viruses in which the nef gene is ...causes ... See full document
8
Patterns of Cytokine Production in Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Human CD8+ T Cells after Stimulation with HIV-1-Infected CD4+ T Cells
... HIV-1- specific CTL clones of the same specificity from the same ...⫹ T cells, even when of the same specificity, display functional heterogeneity in cytokine ...different T-cell ... See full document
8
A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation.
... the nef gene in causing lymphocyte ...expressed human immunodeficiency virus type 1 (HIV-1) nef in the thymus displayed T-cell hyperactivation, CD4 ... See full document
6
Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells
... ⫹ T-cell responses could be primed to five different 9-mer or 20-mer peptides derived from HIV-1 Gag and reverse transcriptase, as well as EBV and FLU, when presented by either moDC, LC, or ...⫹ ... See full document
12
Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.
... to Nef. Incubation of GST-Nef 27 fusion protein with lysates prepared from MT-2 cells copre- cipitated seven cellular proteins, approximately 24, 27, 32, 36, 44, 50, and 56 kDa in size ...with Nef, ... See full document
9
Downregulation of the T-Cell Receptor by Human Immunodeficiency Virus Type 2 Nef Does Not Protect against Disease Progression
... and Nef-induced TCR ...plasma virus is one of ...to cell surface receptors (11), Tat internalization by uninfected cells (12), and antigenic stimulation ...by Nef is present and visible ... See full document
5
Zeta Chain of the T-Cell Receptor Interacts with nef of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2
... for antigen recognition, but the short, 5-aa cytoplasmic domains of the TCR a and b subunits are insufficient to couple to the intracellular signaling ...HIV-2 nef, but not HIV-1 nef, ... See full document
8
Human Immunodeficiency Virus Type 1 Nef Incorporation into Virions Does Not Increase Infectivity
... protein Nef contributes to the optimal infectivity of human and simian immunodeficiency ...for Nef during viral biogenesis particles suggests that Nef might play a role in this ... See full document
12
Human Immunodeficiency Virus Nef Induces Rapid Internalization of the T-Cell Coreceptor CD8αβ
... HIV-1 Nef protein in perinuclear vacu- oles, and our observation that the CD8 ␣ -chain is dispensable for the down-regulation effect, we suggest that Nef interacts directly or indirectly with the CD8 ... See full document
13
Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T Lymphocytes
... is Nef not required for HIV-1 replication in many immortalized T-cell lines (41, 57)? Assuming that CD4 down- regulation by Nef is necessary for viral egress and/or optimal virion ... See full document
9
Disulfide bond formation in the human immunodeficiency virus type 1 Nef protein.
... To evaluate the effect of wild-type and cysteine mutant ELI and LAI Nef proteins on virus replication, the CD4+ T-cell line Jurkat and primary peripheral blood mononuclear cells PBMCs we[r] ... See full document
5
Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity.
... No depletion of CD4+ human thymocytes was observed in implants infected with either HIV-lJRCSF or its nef mutant at 3 or 6 weeks postinfection compared with controls consisting of mock-i[r] ... See full document
8
Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity in the Absence of Matrix
... of virus were used to infect GHOST-CXCR4 cells, and virus production by the infected cells was then examined after metabolic labeling as described ...of Nef on virus production after a single ... See full document
6
Dynamic Evolution of the Human Immunodeficiency Virus Type 1 Pathogenic Factor, Nef
... within Nef sequences from a single patient at a single time point to be of interest, (ii) we consider variation in Nef sequences from a single patient at different time points to be potentially significant, ... See full document
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