[PDF] Top 20 Human immunodeficiency virus type 1 Rev function requires continued synthesis of its target mRNA.
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Human immunodeficiency virus type 1 Rev function requires continued synthesis of its target mRNA.
... how Rev functions, it remains unclear as to how the interaction of Rev with its target mRNAs overcomes the constitutive sup- pression of their transport to the ...the Rev-regulated ... See full document
8
Ataxia-Telangiectasia-Mutated (ATM) Protein Can Enhance Human Immunodeficiency Virus Type 1 Replication by Stimulating Rev Function
... ATM function requires the formation of a complex with MRE11 (9, ...the virus-induced transactivation of  -Gal activity from a stably integrated HIV-1–LTR–  -Gal construct (10) ...later. ... See full document
8
Human chromosome 6- and 11-encoded factors support human immunodeficiency virus type 1 Rev function in A9 cells.
... of human chromosome 6 in A9 cells could rescue Rev function in ...single human chromosomes 6, 8, 11, or 12 were transfected with the reporter plasmid pCMV128 alone or cotransfected with ... See full document
5
Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function.
... The human immunodeficiency virus (HIV) is capable of infecting a wide variety of cells (for a review, see reference ...of virus production is target cell dependent and can vary ... See full document
9
RNA aptamers selected to bind human immunodeficiency virus type 1 Rev in vitro are Rev responsive in vivo.
... sequester Rev (29, 30), or transdomi- nant Rev proteins to inhibit Rev function (1, 14, 21, 34, ...that Rev re- sponsiveness may be more refractive to the evolution of resis- ... See full document
9
CD4 Glycoprotein Degradation Induced by Human Immunodeficiency Virus Type 1 Vpu Protein Requires the Function of Proteasomes and the Ubiquitin-Conjugating Pathway
... (24), requires ATP consumption (6), and is a membrane-dependent process ...that target the proteins for destruction by proteases in the secretory ... See full document
9
The rev-responsive element negatively regulates human immunodeficiency virus type 1 env mRNA expression in primate cells.
... from human and monkey cells, indicate that Rev protein, in binding to the RRE, binds at or close to a negative regulatory signal that it sup- ...the Rev response through its capacity to bind ... See full document
5
Effect of Ethanol on Monocytic Function in Human Immunodeficiency Virus Type 1 Infection
... of mRNA after treatment (Fig. 1 and Table ...the human macrophage hybridomas was associated with loss of mRNA for IL-1a, IL-1b, and TNF-a ...cytokine mRNA produc- tion, since TGF-b was ... See full document
9
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis.
... including human immunodefi- ciency virus type 1 (HIV-1), are characterized by the presence of a number of accessory genes in addition to the prototypic gag, pol, and env reading frames ... See full document
9
Repair of a Rev-Minus Human Immunodeficiency Virus Type 1 Mutant by Activation of a Cryptic Splice Site
... all virus variants ...exon 1-2 splice product (using 5⬘ ss #4 and 3⬘ ss #7), and this was verified by sequence ...revertant virus, sev- eral additional, faster-migrating RT-PCR products were ob- ... See full document
6
Diminished Rev-Mediated Stimulation of Human Immunodeficiency Virus Type 1 Protein Synthesis Is a Hallmark of Human Astrocytes
... FIG. 1. Stimulatory capacity of HIV-1 trans-activating factors Rev and Tat in human astrocytoma and Rev-permissive control cell ...diminished Rev response, whereas the activity ... See full document
11
Restriction of Human Immunodeficiency Virus Type 1 Rev Function in Murine A9 Cells Involves the Rev C-Terminal Domain
... Rev function in A9 cells can be rescued for singly spliced transcripts but not for unspliced ...HIV-1 Rev function is re- stricted ...complement Rev function has been ... See full document
7
Nucleoporins Nup98 and Nup214 Participate in Nuclear Export of Human Immunodeficiency Virus Type 1 Rev
... that Rev is able to recruit both Nup98 and Nup214, but not Nup153, to the ...inhibit Rev-mediated expression by interfering with Rev’s nuclear ...in human cells. The fact that the interaction of ... See full document
8
Human immunodeficiency virus type 1 Rev activation can be achieved without Rev-responsive element RNA if Rev is directed to the target as a Rev/MS2 fusion protein which tethers the MS2 operator RNA.
... When the RRE is replaced by a heterologous MS2 phage operator sequence, Rev will facilitate the cytoplasmic expression of human immunodeficiency virus mRNAs containing this sequence if d[r] ... See full document
12
Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene products.
... However, both a singly spliced and a genome-length viral RNA species were detected by the vif-specific probe in cells transfected with the wild-type HIV-1 proviral expression plasmid Fig[r] ... See full document
5
Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual.
... of Rev activation domain sequences in the HIV da- tabase, with regard to the leucines at positions 75, 78, 81, and 83, demonstrated only one divergent sequence (HIVMN) within the subtype B viruses (n 5 65) as well ... See full document
11
Rev Inhibition Strongly Affects Intracellular Distribution of Human Immunodeficiency Virus Type 1 RNAs
... 116-amino-acid Rev protein of human immunodeficiency virus type 1 (HIV-1), a lentivirus, interacts with the viral RNA and mediates its nuclear ...of Rev ... See full document
12
Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.
... To investigate the mechanism of the positive influence of nef, single-cycle viral replication was initiated by infection with high-titer virus preparations and by direct Downloaded from [r] ... See full document
9
Target Cell Type-Dependent Modulation of Human Immunodeficiency Virus Type 1 Capsid Disassembly by Cyclophilin A
... the target cells, cytoplasmic lysates were analyzed directly (“Input”) or were separated over a 50% sucrose cushion into supernatant (“Sup”) and particulate (“Pellet”) ... See full document
12
Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency.
... To determine whether a functional threshold level of Rev is required to allow efficient HIV-1 replication, CD4-positive HeLa cells, constitutively expressing a Rev-deficient provirus, we[r] ... See full document
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