[PDF] Top 20 Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype
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Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype
... The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for the high spontaneous and induced reactivation ... See full document
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Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... he herpes simplex virus 1 (HSV-1) infects its human host through multiple routes, stimulating strong immune re- sponses that resolve the acute infection but prove unable to pre- vent ... See full document
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Region of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient for Wild-Type Spontaneous Reactivation Promotes Cell Survival in Tissue Culture
... be associated with polyribosomes ...could inhibit apoptosis by regulating tran- scription of one or more cellular ...of spontaneous reactivation or for blocking ...can both be ... See full document
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A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... ocular herpes simplex virus type 1 (HSV-1) infection, the virus travels up axons and establishes a lifelong latent infection in neurons of the trigeminal ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... and herpes simplex virus type 1 ...the virus can also enter a latent state in these ...The latency-associated transcript (LAT) regulates the establishment of ... See full document
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Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... During latency, HSV-1 and HSV2-LAT-S1 did not re- activate ...lasting 1 to 2 days, similar in character to recurrences produced by HSV-2, HSV2-LAT-P1, and ...chimeric virus, which contained ... See full document
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Two Small RNAs Encoded within the First 1.5 Kilobases of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Can Inhibit Productive Infection and Cooperate To Inhibit Apoptosis
... coding sequences and the core LAT promoter (dLAT2903) or the ...FIG. 1. Schematic of HSV-1 and organization of the LAT ...⫹ 1 indicate the start of LAT transcription (genomic nt ...coding ... See full document
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Mutations in the 5' end of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpes.
... of latency and is a poor predictor of virus reactivation, then what role does this gene play? It remains possible that the arbiter of reactivation is not LAT accumulation as much as the ... See full document
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Regions of the Herpes Simplex Virus Type 1 Latency-Associated Transcript That Protect Cells from Apoptosis In Vitro and Protect Neuronal Cells In Vivo
... inhibiting apoptosis in vitro ...against apoptosis in vitro and that these results correlated directly with spontaneous reactivation phenotypes in ...exon 1-exon 2 ...5⬘ ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... the reactivation phenotype within the primary LAT ...tion transcript termination signal inserted at various sites along the primary transcript, we present evidence that the epineph- ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... Since both dLAT371 and LAT3.3A have wild-type rates of sponta- neous reactivation, the region ...taneous reactivation, but the effects of this must not be ...maximum spontaneous ... See full document
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Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latency.
... distinct reactivation phenotypes (each virus has a preferred site for reactivation [20]) and that the RNA se- quences of the HSV-1 and HSV-2 LAT introns are quite dif- ferent ...the ... See full document
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A Herpes Simplex Virus Type 1 Mutant Expressing a Baculovirus Inhibitor of Apoptosis Gene in Place of Latency-Associated Transcript Has a Wild-Type Reactivation Phenotype in the Mouse
... herpesvirus 1 (BHV-1) LAT homologue, the LR gene, can efficiently substitute for the LAT function involved in supporting the wild-type HSV-1 re- activation phenotype ...can ... See full document
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Mechanisms of herpes simplex virus type 1 reactivation.
... while reactivation occurred in 16 of 28 cultures established in the absence of BVDU, 10 of the re- maining 12 cultures reactivated following a secondary heat ... See full document
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Sequences of herpes simplex virus type 1 that inhibit formation of stable TK+ transformants.
... All restriction endonuclease digestions were carried out as specified by the manufacturer Boehringer Mannheim, and * 2989 Downloaded from http://jvi.asm.org/ on November 10, 2019 by gues[r] ... See full document
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Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1.
... By using various fragments and deletion constructs, this promoter activity 3269 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest To identify promoter regions which contr[r] ... See full document
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Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... During latency of herpes simplex virus type 1 in sensory neurons, the transcription of viral genes is restricted to the latency-associated transcripts ...of ... See full document
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Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... of latency between the transgenic and nontransgenic mice was ...rescue reactivation defects of LAT mutants in ...or reactivation * Corresponding ... See full document
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ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
... HSV-1 reactivation pro- cess? Latency in the herpesvirus field has long been defined as the absence of infectious virus in cells or tissues that contain viral genomes, whereas ... See full document
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The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... this type of comparison, however, is that it requires comparing separate ChIP experiments for DRG from mice infected with two different virus ...histones associated with the LAT promoter, the 5 ⬘ ... See full document
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