[PDF] Top 20 Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA.
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Identification of a highly conserved sequence element at the 3' terminus of hepatitis C virus genome RNA.
... novel 3 9 - terminal sequence joined, at exactly the same junction, to the sequences of the synthetic ...this 3 9 end was generated by the action of contam- inating RNases or premature termination ... See full document
9
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity.
... in RNA polymerases with levels of enzyme activity between 5 and 20% of wild-type levels ...immunodeficiency virus RT, this lysine, together with the highly conserved carboxylates of motifs A ... See full document
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Hepatitis C Virus-Encoded Enzymatic Activities and Conserved RNA Elements in the 3′ Nontranslated Region Are Essential for Virus Replication In Vivo
... HCV RNA element examined in this study was the conserved portion of the 3⬘ ...HCV genome RNA terminated with poly(A) (20) or poly(U) (for examples, see references 21, 30, and ... See full document
6
3′ Nontranslated RNA Signals Required for Replication of Hepatitis C Virus RNA
... the 3⬘ stem sequence of SL1, in a similar in vitro ...the genome so as to initiate de novo transcription from the 3⬘ terminal ...novo RNA synthesis at the 3⬘ terminus by ... See full document
12
Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome.
... Hepatitis C virus (HCV) contains a positive-stranded RNA genome of approximately ...overall sequence diversity among individual HCV isolates, the 3 * -end 98 nucleotides ... See full document
9
Highly Permissive Cell Lines for Subgenomic and Genomic Hepatitis C Virus RNA Replication
... HCV genome (GenBank accession ...This sequence was assembled from chemically synthesized DNA oligonucleotides in a stepwise PCR assay essentially as described previously ...full-length genome with ... See full document
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Role of RNA Structures in Genome Terminal Sequences of the Hepatitis C Virus for Replication and Assembly
... reporter virus genome used throughout this study in the ( ⫹ ) and ( ⫺ ) ...) RNA and 3 ⬘ end of ( ⫺ ) RNA are ...spacer element (not ...Predicted RNA secondary structure ... See full document
7
Kissing-Loop Interaction in the 3′ End of the Hepatitis C Virus Genome Essential for RNA Replication
... The hepatitis C virus (HCV) is the only member of the Hepacivirinae within the Flaviviridae family ...an RNA genome of positive polarity that in the case of HCV has a length of about ... See full document
13
Hepatitis C Virus RNA Replication Requires a Conserved Structural Motif within the Transmembrane Domain of the NS5B RNA-Dependent RNA Polymerase
... colon, highly similar; dot, similar), (ii) the predicted transmembrane segments (see ...the C terminus of GBV-B NS5B. The box indicates the conserved structural motif, as described in the ... See full document
5
Sequence and Structural Elements at the 3′ Terminus of Bovine Viral Diarrhea Virus Genomic RNA: Functional Role during RNA Replication
... diarrhea virus (BVDV), a member of the genus Pestivirus in the family Flaviviridae, has a positive-stranded RNA genome consisting of a single open reading frame and untranslated regions (UTRs) at the ... See full document
13
Modulation of hepatitis C virus RNA Abundance.pdf
... ribosomal RNA (rRNA) gene repeats (rDNA), recombination helps maintain copy number (3) and the evolutionary stability of the repeats ...a highly conserved sequence that corresponds to a ... See full document
6
Specific Interaction between the Hepatitis C Virus NS5B RNA Polymerase and the 3′ End of the Viral RNA
... subsequent RNA replication; a coding region of about 300 nt immediately before the stop codon of the viral genome may play an important role in the viral rep- ...lication. Highly conserved ... See full document
6
Effect of Mutations in the Mouse Hepatitis Virus 3′(+)42 Protein Binding Element on RNA Replication
... leader sequence present at the 5 ⬘ end of all the MHV mRNAs and the genome ...negative-sense RNA complementary to mRNA7, encoding the N gene, nested PCR was carried out using primer sets that ... See full document
16
A Hepatitis C Virus cis-Acting Replication Element Forms a Long-Range RNA-RNA Interaction with Upstream RNA Sequences in NS5B
... of conserved base pairing within SL9266 and between the bulge loop of SL9266 and the upstream sequences rendered the chimera ...replaced sequence meant that further site- directed mutagenesis was required ... See full document
15
Base Pairing between Hepatitis C Virus RNA and MicroRNA 122 3′ of Its Seed Sequence Is Essential for Genome Stabilization and Production of Infectious Virus
... and 3 of the HCV RNA by an additional base pair ...HCV RNA upstream of the S1 seed match site rather than a defect in replicase recognition of HCV ...viral RNA, as shown in ...HCV RNA ... See full document
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Structure of the 3' terminus of the hepatitis C virus genome.
... The 3 * tail of the type III/2a HCV ...III/2a genome had a 3 9 tail sequence similar to that of the type II/1b ...III/2a 3 9 tail, we performed two overlapping sets of RT-nested PCR and ... See full document
6
Secondary Structure of the 3′ Terminus of Hepatitis C Virus Minus-Strand RNA
... Hepatitis C virus (HCV), which is essentially transmitted by blood, represents a worldwide major health ...chronic hepatitis, cir- rhosis, and hepatocarcinomas (13, 35, 48). HCV is an ... See full document
11
cis-Acting RNA Signals in the NS5B C-Terminal Coding Sequence of the Hepatitis C Virus Genome
... catalyzes RNA synthesis in a cooperative manner ...97-amino-acid C-terminal domain of NS5B is required for this interaction ...the C-terminal 60 amino acids can be deleted without loss of enzyme ... See full document
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Secondary structure determination of the conserved 98-base sequence at the 3' terminus of hepatitis C virus genome RNA.
... other RNA viruses, conserved sequences or structures at the termini of viral RNAs often modulate translation, replica- tion, and/or packaging via interactions with protein(s) and/or other RNA ... See full document
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Identification of a Conserved RNA Replication Element (cre) within the 3Dpol-Coding Sequence of Hepatoviruses
... A virus (HAV), a member of the family Picorna- viridae, is a common etiological agent of acute hepatitis in ...primary sequence of the positive-sense, single-stranded RNA genome of HAV ... See full document
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