[PDF] Top 20 Identification of Kaposi's Sarcoma-Associated Herpesvirus LANA Regions Important for Episome Segregation, Replication, and Persistence
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Identification of Kaposi's Sarcoma-Associated Herpesvirus LANA Regions Important for Episome Segregation, Replication, and Persistence
... plasmid segregation of the different LANA mutants while accounting for differences in rates of cell growth, the percentages of GFP-positive cells were compared at a mutant-specific, plasmid-specific time ... See full document
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H2AX Phosphorylation Is Important for LANA-Mediated Kaposi's Sarcoma-Associated Herpesvirus Episome Persistence
... Episome retention assay. HEK-293–BAC36 –KSHV cells were trans- fected with pGIPz-shCtrl or pGIPz-shH2AX plasmids. After 2 days post- transfection, the cells were grown in DMEM containing 1 ⫻ puromycin (2 g/ml), ... See full document
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Kaposi’s Sarcoma-Associated Herpesvirus LANA-Adjacent Regions with Distinct Functions in Episome Segregation or Maintenance
... binding Segregation 33 330 Repeats 931 AAAA FIG 1 Schematic representation of KSHV LANA and deletion ...(EQE) regions and the putative leucine zipper (LZ) are ...EQE regions each contain ... See full document
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The Internal Kaposi's Sarcoma-Associated Herpesvirus LANA Regions Exert a Critical Role on Episome Persistence
... DNA replication assay. For DNA replication assays, 10 ⫻ 10 6 cells were transfected with 5 g of p8TR, using Amaxa nucleofactor program O-17 and solution ...KSHV LANA and LANA deletion mutants ... See full document
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The Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 N Terminus Is Essential for Chromosome Association, DNA Replication, and Episome Persistence
... At least two EBNA1 regions mediate chromosome association (18, 28, 41). Of interest, the EBNA1 chromosome association regions and LANA1 5 to 13 are all rich in basic residues. FIG. 6. Alanine substitutions ... See full document
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Murine Gammaherpesvirus 68 Expressing Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) Reveals both Functional Conservation and Divergence in LANA Homologs
... KSHV LANA in mice promotes the development of lymphoid hyperplasia and lymphoma ...MHV68 LANA (kLANA and mLANA, respectively) proteins have diverged considerably (13, ...(P/S)-rich regions and ... See full document
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Bub1 and CENP-F Can Contribute to Kaposi's Sarcoma-Associated Herpesvirus Genome Persistence by Targeting LANA to Kinetochores
... endogenous LANA protein ...for segregation and mainte- nance of the KSHV ...of LANA with the kinetochore via the interaction with these other centromeric ...of LANA with the host ...with ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Recruits Topoisomerase IIβ for Latent DNA Replication of the Terminal Repeats
... Kaposi’s sarcoma-associated herpesvirus (KSHV) plays a major role in maintaining latency and is critical for the perpetual segregation of viral episomes to the progeny nuclei of newly divided ... See full document
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Identification of Host-Chromosome Binding Sites and Candidate Gene Targets for Kaposi's Sarcoma-Associated Herpesvirus LANA
... that LANA modulates a spectrum of cellular genes when ectopically expressed ...Whether LANA binds directly or indirectly to the regulatory regions of these genes remains largely ...whether ... See full document
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Timeless-Dependent DNA Replication-Coupled Recombination Promotes Kaposi's Sarcoma-Associated Herpesvirus Episome Maintenance and Terminal Repeat Stability
... lytic replication. These findings suggest that Tim FIG 3 Replication fork pausing factor TIM associates with the TR region of ...and LANA-binding sites within each ...to LANA, Tim, Tipin, Pol ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Can Interact with the Nuclear Mitotic Apparatus Protein To Regulate Genome Maintenance and Segregation
... efficient segregation of the replicated KSHV genome into daughter ...is important for ...of LANA have different functions and can cooperate to tether the KSHV genome on human chromosomes ... See full document
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Latency-Associated Nuclear Antigen (LANA) of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Origin Recognition Complexes at the LANA Binding Sequence within the Terminal Repeats
... Kaposi’s sarcoma-associated herpesvirus (KSHV) DNA persists in latently infected cells as an episome via tethering to the host ...that LANA is important for episome ... See full document
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Role of Kaposi's Sarcoma-Associated Herpesvirus C-Terminal LANA Chromosome Binding in Episome Persistence
... C-terminal LANA chromo- some binding does not affect mitotic chromosome localization of stably expressed, full-length ...minal LANA chromosome binding have no effect on chromo- some targeting of full-length ... See full document
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Disruption of Kaposi's Sarcoma-Associated Herpesvirus Latent Nuclear Antigen Leads to Abortive Episome Persistence
... Kaposi’s sarcoma-associated herpesvirus (KSHV) episome ...and replication of KSHV terminal repeat-containing ...in episome persistence in the context of full-length KSHV ... See full document
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Kaposi sarcoma–associated herpesvirus: immunobiology, oncogenesis, and therapy
... condition associated with EBV infection of B cells after thera- peutic ...diseases associated with these other herpesviruses suggests that in addition to KSHV and in addition to immune deficiency, genomic ... See full document
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Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas
... by LANA or other viral ...cancers. LANA is a mul- tifunctional protein that is consistently expressed in all KSHV- associated ...of LANA is to tether the KSHV episome to cellular ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Contributes to Viral Latent Replication by Activating Phosphorylation of Survivin
... is important for regulating the activities of p300 and ...that LANA and AK-B complex enhanced the phosphorylation of survivin and upregulates H3 acetylation, and this boosted KSHV replication in ... See full document
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In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4
... Virus persistence in proliferating, latently infected cells requires episome persis- ...for episome maintenance. During episome persistence, LANA tethers viral DNA to mitotic ... See full document
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The Kaposi's Sarcoma-Associated Herpesvirus LANA Protein Stabilizes and Activates c-Myc
... the LANA that is expressed in latently KSHV-infected cells would be expected to upregulate Myc transcriptionally through LANA-mediated induction of -catenin which is a known transactivator of Myc ...that ... See full document
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Bub1 in Complex with LANA Recruits PCNA To Regulate Kaposi's Sarcoma-Associated Herpesvirus Latent Replication and DNA Translesion Synthesis
... DNA replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) initiates at the terminal repeat (TR) element and requires trans-acting elements, both viral and cellular, such as ORCs, MCMs, ... See full document
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