[PDF] Top 20 Identifying substrates of CDK2: cyclin A.
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Identifying substrates of CDK2: cyclin A.
... The cyclin activators of Cdc28 can be broadly classified into two groups: the Clns (Clnl-3), which act in G1 and are required for Start, and the B-type cyclins (Clbl-6) which control S-phase and mitotic ... See full document
189
Functional Interaction between the Bovine Papillomavirus Virus Type 1 Replicative Helicase E1 and Cyclin E-Cdk2
... on cyclin E-Cdk2 kinase ...either cyclin E or Cdk2 (4, 14, 15, ...nopus cyclin E-Cdk2 interacts with E1 specifically and show * Corresponding ... See full document
8
A Screen for Modifiers of Cyclin E Function in Drosophila melanogaster Identifies Cdk2 Mutations, Revealing the Insignificance of Putative Phosphorylation Sites in Cdk2
... periodic expression could rescue the lethality associated three RNP-type RNA binding domains and a novel char- with the Cdk2 mutant background. As shown in Table acteristic C-terminal domain defining a family of ... See full document
12
Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
... It has been well documented that mutations of phosphorylation sites within proteins can lead to aberrant sub-cellular localisation causing various disease states (Hung and Link, 2011). Ciz1 has been shown to largely ... See full document
131
Overexpression of p21waf1 in Human T-Cell Lymphotropic Virus Type 1-Infected Cells and Its Association with Cyclin A/cdk2
... of cyclin/cdk’s, depending on the cell line tested, including cyclin D/cdk4, cyclin B1/cdc2, cyclin E/cdk2, and cyclin A/cdk2 (4, 29, 35), and inhibit their enzymatic ... See full document
14
PIWIL2 promotes progression of non small cell lung cancer by inducing CDK2 and Cyclin A expression
... proteins, Cyclin pro- teins and GAPDH were determined by western ...SAB4500050; CDK2, SAB4503706; CDK4, SAB4300695), Cyclins (Cyclin B, SAB4503501; Cyclin A, SAB4503499; Cyclin D1, ... See full document
10
INHIBITION STUDIES OF TERPENE BASED NATURAL PRODUCTS WITH CYCLIN DEPENDENT KINASE 4 (CDK4 MIMIC CDK2)
... Cyclin dependent kinases (CDKs) are known as cell cycle regulators in eukaryotic cell cycle. Different CDKs (CDK2, CDK4 etc.) are having structure homology among them. Using computer based molecular ... See full document
8
Modulation of apoptosis by the cyclin dependent kinase inhibitor p27Kip1
... the cyclin kinase inhibitor p27 Kip1 (p27) in limiting proliferation has been ...expression. Cyclin A–cyclin-dependent kinase 2 (CDK2) activity, but not cyclin E–CDK2 activity, ... See full document
9
Functional Interactions between Herpesvirus Oncoprotein MEQ and Cell Cycle Regulator CDK2
... major CDK2 phos- phorylation site in vitro is serine 42, which is located between BR1 and ...Alternatively, CDK2 phosphorylation of MEQ may enhance the interaction between exportin and a nearby puta- tive ... See full document
12
Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer
... active cyclin D1–Cdk4 com- plexes, potentially decreasing the p27 available for cyclin E–Cdk2 inhibition ...to cyclin E–Cdk2 ...increased cyclin D1 or ...of cyclin D1 and ... See full document
9
The role of cyclin D2 and p21/waf1 in human T cell leukemia virus type 1 infected cells
... the cyclin Ds and p21/waf1 are often seen deregulated in viral ...instance, cyclin D2 is upregulated in Epstein-Barr virus (EBV) infected cells [47,48] and cyclin D1 is upregulated in Sim- ian virus ... See full document
17
Mitotic p21 Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation
... of cyclin B1 or using the specific Cdk1 inhibitor RO-3306, reduces strongly the phosphorylation signal of ...by Cdk2/cyclin E in the S phase [14], Cdk6/cyclin K upon viral infection [15] and ... See full document
14
Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer
... -deoxyuridine); CDK2: Cyclin- dependent kinase 2; ChIP: Chromatin immunoprecipitation; Cimp − : :Low CpG island methylator phenotype; Cimp+: High CpG island methylator phenotype; C-Myc: MYC proto-oncogene, ... See full document
17
Original Article Expression of cell-cycle regulators is associated with invasive behavior and poor prognosis in prolactinomas
... Abcam); Cyclin D1 (ab21699, 1/100; Abcam); Cyclin E1 (ab9517, 1/30; Abcam); p16 (ab54- 210, 1/1500; Abcam); p27 (ab32304, 1/500; Abcam); Cdk2 (ab77671, 1/600; Ab- cam); Cdk4 (ab108357, 1/ 400; ... See full document
11
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1
... as cyclin binding does in CDK2 and dimerization does in EGFR [12], such that binding of a protein partner stabilizes the aC-helix in the “in” posi- tion, even when the kinase active site is ... See full document
16
Induction of cyclins E and A in response to mitogen removal: a basic alteration associated with the arrest of differentiation of C2 myoblasts transformed by simian virus 40 large T antigen.
... the cyclin E promoter itself ...by cyclin A-cdk2, which down- regulates both the DNA-binding and the transactivating abilities of E2F1 (15, 37, 57, ...with cdk2 active enough to keep a sizable ... See full document
8
The Role of CDKs in Normal and Neoplastic Proliferation
... Pituitary glands were homogenized with an eppendorpf mortar in lysis buffer, 150 mM NaCl, 1.0% IGEPAL, 0.5% DOC, 0.1% SDS, 50mM Tris (pH 8.0). Skin protein lysates were collected from epidermal skin scrapes with lysis ... See full document
231
<p>Gephyrin suppresses lung squamous cell carcinoma development by reducing mTOR pathway activation</p>
... of cyclin D1 and CDK2, indicating that gephyrin suppressed LUSC development, at least in part, by negatively mediating the expression of these ...Because cyclin D1 and CDK2 are the target ... See full document
9
Expression of an S phase stabilized version of the CDK inhibitor Dacapo can alter endoreplication
... provide evidence that S phase-coupled destruction of Dap has a modulatory role in endocycling cells, even in tissues such as the salivary gland where removal of Dap function does not prevent endocycle progression (Zielke ... See full document
11
Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels
... [52]. CDK2 forms a complex with cyclinE1 to promote G1/S transition and forms a complex with cyclinA to bypass the S phase and the G2/M phase ...of CDK2 are not significantly altered in either ... See full document
15
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