[PDF] Top 20 Effects of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Reverse Transcriptase Processing, Activity, and Drug Sensitivity
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Effects of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Reverse Transcriptase Processing, Activity, and Drug Sensitivity
... HIV-1 protease, the effect of impaired cleavage of viral enzymes could have considerable effects on viral rep- ...three virus pairs studied here were characterized by a strong difference in ... See full document
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Subunit-specific mutagenesis of the cysteine 280 residue of the reverse transcriptase of human immunodeficiency virus type 1: effects on sensitivity to a specific inhibitor of the RNase H activity.
... H activity of HIV-1 RT can be inactivated by NEM (13, 14, 21, ...confers resistance via the change in the p51 or the p66 subunit of the RT heterodimer, we used vectors that allow us to generate ... See full document
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Quantification of the Effects on Viral DNA Synthesis of Reverse Transcriptase Mutations Conferring Human Immunodeficiency Virus Type 1 Resistance to Nucleoside Analogues
... conferring resistance to antiretro- viral drugs may have implications for viral pathogenicity, viral transmission, and the treatment of HIV-1 ...of resistance-associated loss of replicative capacity ... See full document
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Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors.
... Protease inhibitors are potent antiviral agents against human immunodeficiency virus type ...with reverse transcriptase inhibitors, however, ... See full document
8
Frequency of Mutations Conferring Resistance to Nucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus Type 1 Infected Patients in Korea
... enzymes reverse transcriptase (RT) and protease (PR) of human immunodeficiency virus (HIV) type 1 (HIV-1); both are encoded by the pol ...RT ... See full document
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Individual Contributions of Mutant Protease and Reverse Transcriptase to Viral Infectivity, Replication, and Protein Maturation of Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... Human immunodeficiency virus type 1 (HIV-1) variants resistant to protease (PR) and reverse transcriptase (RT) inhibitors may display impaired ... See full document
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Sensitive Phenotypic Detection of Minor Drug Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Variants
... the effects of single versus dual protease inhibitor-containing regimens in 481 patients on a failing regimen containing a protease inhibitor ...analog reverse transcriptase ... See full document
9
Mutations That Abrogate Human Immunodeficiency Virus Type 1 Reverse Transcriptase Dimerization Affect Maturation of the Reverse Transcriptase Heterodimer
... abrogate human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) dimerization on virus replication is not known, as mutations shown previously ... See full document
11
Interaction of Reverse Transcriptase (RT) Mutations Conferring Resistance to Lamivudine and Etravirine: Effects on Fitness and RT Activity of Human Immunodeficiency Virus Type 1
... the drug susceptibility, replication capacity, fitness profiles, relative fitness, and virion-associated RT activ- ity of recombinant HIV-1 carrying mutations that confer resis- tance to the NNRTIs ETV and ... See full document
6
Retracing the Evolutionary Pathways of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors: Virus Fitness in the Absence and in the Presence of Drug
... Protease inhibitors (PIs) are widely used in the highly active antiretroviral therapy regimens currently prescribed for the treatment of human immunodeficiency virus type ... See full document
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Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Target Distinct Phases of Early Reverse Transcription
... of virus isolated from patients taking NVP ...inhibitory activity against Taq DNA polymerase ...the effects of the various drugs in our NERT-PCR assay to their effects in a commercial ... See full document
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Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors.
... the protease mutations impaired polyprotein processing, consistent with a decrease in enzyme activity in ...wild-type virus on T-cell ...upon drug removal, confirming its impact ... See full document
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Genotypic, Phenotypic, and Modeling Studies of a Deletion in the β3-β4 Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene That Is Associated with Resistance to Nucleoside Reverse Transcriptase Inhibitors
... a 1-amino-acid deletion in their RT ...inhibitor resistance mutations occur (23) and where resistance-conferring insertions have been recently re- ported (5, 16, 28, ...one drug from all three ... See full document
7
Characterization and Structural Analysis of Novel Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involved in the Regulation of Resistance to Nonnucleoside Inhibitors
... both drug-naı¨ve and NNRTI-treated popu- ...inhibitory activity of the NNRTIs, thus rep- resenting an interesting example of synergistic interactions be- tween immune and drug ...and drug ... See full document
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Insertions in the Reverse Transcriptase Increase both Drug Resistance and Viral Fitness in a Human Immunodeficiency Virus Type 1 Isolate Harboring the Multi-Nucleoside Reverse Transcriptase Inhibitor Resistance 69 Insertion Complex Mutation
... conferring resistance to protease and RT inhibitors (PI and RTI, respectively) (for reviews, see references 8, 26, and ...wild-type virus in the absence of drug (18, ... See full document
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Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... with drug resistance muta- tions, the effects of drug-resistant mutants and combined drugs on HIV-1 mutation frequencies were ...the virus mutation frequencies in the presence of ... See full document
13
In Vitro Evolution of the Human Immunodeficiency Virus Type 1 Gag Protease Region and Maintenance of Reverse Transcriptase Resistance following Prolonged Drug Exposure
... enhanced processing has been demonstrated (30), and since they do not affect drug binding they could contribute to cross-resistance to all ...of resistance with IDV was sufficient to cause ... See full document
6
Resistance to Nucleoside Analog Reverse Transcriptase Inhibitors Mediated by Human Immunodeficiency Virus Type 1 p6 Protein
... of processing of the Gag55 precursor and of precursor p25 to mature p24 equimolarity ...of protease autocleavage, estimated by using an NC-TF-p6-PR expression vector in a reticulocyte lysate transcription ... See full document
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Involvement of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations in the Regulation of Resistance to Nucleoside Inhibitors
... leukemia virus RT, and amplified with Amplitaq-Gold polymerase enzyme by using two different sequence-specific primers for 40 ...entire protease and the first 335 amino acids of the reverse ... See full document
13
Unique Thermodynamic Response of Tipranavir to Human Immunodeficiency Virus Type 1 Protease Drug Resistance Mutations
... HIV protease inhibitor can minimize the deleterious effects of resistance ...Previously, inhibitors maintaining activity in the setting of mu- tations have partially compensated for ... See full document
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