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[PDF] Top 20 Human Immunodeficiency Virus Type 1 Subtype Distribution in the Worldwide Epidemic: Pathogenetic and Therapeutic Implications

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Human Immunodeficiency Virus Type 1 Subtype Distribution in the Worldwide Epidemic: Pathogenetic and Therapeutic Implications

Human Immunodeficiency Virus Type 1 Subtype Distribution in the Worldwide Epidemic: Pathogenetic and Therapeutic Implications

... the worldwide HIV-1 epidemic is still growing, with continuous molecular evolution of existing subtypes and identification of new CRFs, as well as ...B subtype is still predominant in Western ... See full document

11

Quantifying Differences in the Tempo of Human Immunodeficiency Virus Type 1 Subtype Evolution

Quantifying Differences in the Tempo of Human Immunodeficiency Virus Type 1 Subtype Evolution

... each subtype was infor- mative—even though the sequences used were not from the same patients for pol and env, the results were similar—and that our method can efficiently separate dN and dS contribu- tions to the ... See full document

8

Human Immunodeficiency Virus Type 1 Subtype F Reverse Transcriptase Sequence and Drug Susceptibility

Human Immunodeficiency Virus Type 1 Subtype F Reverse Transcriptase Sequence and Drug Susceptibility

... inter- subtype pol diversity might be reflected by particular drug susceptibility ...HIV-1 subtype F is only a minor form of HIV-1 but is widely distributed (4, 7, 10, 13, 16, 18, 20, 21, 23, ... See full document

5

The Explosive Human Immunodeficiency Virus Type 1 Epidemic among Injecting Drug Users of Kathmandu, Nepal, Is Caused by a Subtype C Virus of Restricted Genetic Diversity

The Explosive Human Immunodeficiency Virus Type 1 Epidemic among Injecting Drug Users of Kathmandu, Nepal, Is Caused by a Subtype C Virus of Restricted Genetic Diversity

... Sequence manipulation and phylogenetic analysis. Primary sequence data were assembled and edited with Geneworks (Intelligenetics, Mountain View, Calif.) on a Power PC (MacIntosh) platform. All subsequent analyses were ... See full document

9

The heterosexual human immunodeficiency virus type 1 epidemic in Thailand is caused by an intersubtype (A/E) recombinant of African origin.

The heterosexual human immunodeficiency virus type 1 epidemic in Thailand is caused by an intersubtype (A/E) recombinant of African origin.

... 1989, human immunodeficiency virus type 1 (HIV-1) has spread explosively through the heterosexual population in ...This epidemic is caused primarily by viruses classified ... See full document

17

CCR5- and CXCR4-Tropic Subtype C Human Immunodeficiency Virus Type 1 Isolates Have a Lower Level of Pathogenic Fitness than Other Dominant Group M Subtypes: Implications for the Epidemic

CCR5- and CXCR4-Tropic Subtype C Human Immunodeficiency Virus Type 1 Isolates Have a Lower Level of Pathogenic Fitness than Other Dominant Group M Subtypes: Implications for the Epidemic

... Competing HIV-1 isolates in vaginal/cervical, penile, and rectal explants as a model for “transmission” fitness. To es- timate “transmission” fitness, we performed dual virus compe- titions in primary ... See full document

14

Molecular Epidemiology of Human Immunodeficiency Virus Type 1 Sub-Subtype A3 in Senegal from 1988 to 2001

Molecular Epidemiology of Human Immunodeficiency Virus Type 1 Sub-Subtype A3 in Senegal from 1988 to 2001

... geographic distribution of various subtypes worldwide (5, 35, ...example, subtype B viruses account for an estimated ...this subtype are primarily seen in the Americas, Western Europe, and ... See full document

7

Infectious Simian/Human Immunodeficiency Virus with Human Immunodeficiency Virus Type 1 Subtype C from an African Isolate: Rhesus Macaque Model

Infectious Simian/Human Immunodeficiency Virus with Human Immunodeficiency Virus Type 1 Subtype C from an African Isolate: Rhesus Macaque Model

... effective human immunodeficiency vi- rus type 1 (HIV-1) ...global epidemic and are subdivided into genetic subtypes or clades designated A, A2, B, C, D, F1, F2, G, H, J, and K ... See full document

9

Genetic and Functional Diversity of Human Immunodeficiency Virus Type 1 Subtype B Nef Primary Isolates

Genetic and Functional Diversity of Human Immunodeficiency Virus Type 1 Subtype B Nef Primary Isolates

... Nef’s crucial role in HIV replication makes it an appealing target for therapeutic intervention in HIV disease. Before this can be achieved it will be important to delimit possible Nef functions by gaining a ... See full document

9

Extensive Intrasubtype Recombination in South African Human Immunodeficiency Virus Type 1 Subtype C Infections

Extensive Intrasubtype Recombination in South African Human Immunodeficiency Virus Type 1 Subtype C Infections

... the subtype C epidemic with the recombinants removed was earlier than that with all ...HIV-1 epidemic in humans is thought to have taken place near 1930 (95% CI, 1913 to 1944) ...the ... See full document

9

Expression and Function of Chemokine Receptors on Human Thymocytes: Implications for Infection by Human Immunodeficiency Virus Type 1

Expression and Function of Chemokine Receptors on Human Thymocytes: Implications for Infection by Human Immunodeficiency Virus Type 1

... and liver when they were 6 to 8 weeks old. Sixteen- to twenty-four-week gesta- tional age tissue was obtained from Advanced Bioscience Resources (Alameda, Calif.). One piece of fetal thymus and two of fetal liver were ... See full document

9

Failure of a human immunodeficiency virus type 1 (HIV-1) subtype B-derived vaccine to prevent infection of chimpanzees by an HIV-1 subtype E strain.

Failure of a human immunodeficiency virus type 1 (HIV-1) subtype B-derived vaccine to prevent infection of chimpanzees by an HIV-1 subtype E strain.

... lated from single-cell suspensions for PCR amplification of proviral DNA. A nested set of primers that flank the V3 loop and recognize isolates from multiple HIV-1 clades was used: outer pair, env1-C (5 9 ... See full document

5

Genetic analysis of human immunodeficiency virus type 1 strains from patients in Cyprus: identification of a new subtype designated subtype I.

Genetic analysis of human immunodeficiency virus type 1 strains from patients in Cyprus: identification of a new subtype designated subtype I.

... of human immunodeficiency virus type 1 (HIV-1) were amplified by PCR from uncultured peripheral blood mononuclear cells obtained from 24 of 25 HIV-1-seropositive patients ... See full document

9

Plasma RNA Viral Load in Human Immunodeficiency Virus Type 2 Subtype A and Subtype B Infections

Plasma RNA Viral Load in Human Immunodeficiency Virus Type 2 Subtype A and Subtype B Infections

... sensitivity, 1 ml of plasma was ultracentrifuged for 1 h at 16,500 ⫻ g at 4°C, and the pellet was resuspended in 140 ␮l of HIV-negative human plasma before ... See full document

6

Genetic Subtype-Independent Inhibition of Human Immunodeficiency Virus Type 1 Replication by CC and CXC Chemokines

Genetic Subtype-Independent Inhibition of Human Immunodeficiency Virus Type 1 Replication by CC and CXC Chemokines

... chemokines are not synergistic (or even additive) in their ac- tions. The data points in Fig. 3 that are marked with an asterisk and a dagger represent, respectively, the isolates most (94KE103, subtype D) and ... See full document

9

Evolution of the human immunodeficiency virus type 1 subtype-specific V3 domain is confined to a sequence space with a fixed distance to the subtype consensus.

Evolution of the human immunodeficiency virus type 1 subtype-specific V3 domain is confined to a sequence space with a fixed distance to the subtype consensus.

... the subtype consensus, irrespective of the initial distance from the subtype ...sub- type consensus can reach 15%, 85% of nucleotide positions within those sequences are still ...the subtype ... See full document

7

Susceptibility of Recently Transmitted Subtype B Human Immunodeficiency Virus Type 1 Variants to Broadly Neutralizing Antibodies

Susceptibility of Recently Transmitted Subtype B Human Immunodeficiency Virus Type 1 Variants to Broadly Neutralizing Antibodies

... neutralizing human immunodeficiency virus type 1 (HIV-1) specific human monoclonal antibodies (MAbs) b12, 2G12, 2F5, and 4E10 to neutralize recently transmitted viruses ... See full document

10

A Reliable Phenotype Predictor for Human Immunodeficiency Virus Type 1 Subtype C Based on Envelope V3 Sequences

A Reliable Phenotype Predictor for Human Immunodeficiency Virus Type 1 Subtype C Based on Envelope V3 Sequences

... In human immunodeficiency virus type 1 (HIV-1) subtype B infections, the emergence of viruses able to use CXCR4 as a coreceptor is well documented and associated with ... See full document

7

CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus.

CXCR4 expression during lymphopoiesis: implications for human immunodeficiency virus type 1 infection of the thymus.

... replication, virus is expressed primarily in CD4 1 /CXCR4 1 ...cell type which further differentiates into a CD4-neg- ative cell type that continues to express virus ... See full document

7

In vivo binding of wild-type and mutant human immunodeficiency virus type 1 Rev proteins: implications for function.

In vivo binding of wild-type and mutant human immunodeficiency virus type 1 Rev proteins: implications for function.

... HAINES' Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina 29425-2230,1 and Department of Microbiology, University of Leicester S[r] ... See full document

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