[PDF] Top 20 The human immunodeficiency virus type 1 long terminal repeat specifies two different transcription complexes, only one of which is regulated by Tat.
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The human immunodeficiency virus type 1 long terminal repeat specifies two different transcription complexes, only one of which is regulated by Tat.
... Radiolabeled oligonucleotide containing the three SP-1 sites from the HIV-1 LTR was incubated with nuclear extracts from HeLa cells lane 2 and 100 ng of the same unlabeled oligonucleotid[r] ... See full document
9
Cell Cycle-Regulated Transcription by the Human Immunodeficiency Virus Type 1 Tat Transactivator
... to Tat, etat extracts were cleared by using the monoclonal antibodies 12CA5 (anti-epitope-tagged Tat) and Tab172 (anti-Tax ...that Tat was specifically immunoprecipitated with the anti-epitope ... See full document
9
Targeting Tat Inhibitors in the Assembly of Human Immunodeficiency Virus Type 1 Transcription Complexes
... negative Tat proteins con- taining the Tat AD alone have shown relatively modest levels of inhibition (6, 19, ...in which molecular crowding can enhance the assembly of large macromolecular ... See full document
13
Functional Domains of Tat Required for Efficient Human Immunodeficiency Virus Type 1 Reverse Transcription
... that Tat may interact with other cellular kinases to stimulate efficient reverse ...transcription. Tat has been re- ported to activate components of signal transduction pathways, including ... See full document
10
A fourth Sp1 site in the human immunodeficiency virus type 1 long terminal repeat is essential for negative-sense transcription.
... of transcription from the negative-sense promoter was approximately 10 times less than from the positive-sense pro- moter and was negatively regulated by ...Findings which suggest that PMA respon- ... See full document
8
Characterization of a Major Histocompatibility Complex Class II X-Box-Binding Protein Enhancing Tat-Induced Transcription Directed by the Human Immunodeficiency Virus Type 1 Long Terminal Repeat
... that human immunodeficiency virus type 1 (HIV-1) shows the highest frequency of X-like box elements per 1,000 bases of ...HIV-1 long terminal repeat ... See full document
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Molecular and functional interactions of transcription factor USF with the long terminal repeat of human immunodeficiency virus type 1.
... in which nonadjacent proteins also, by DNA bending and looping, can interact among themselves and with the basal transcriptional ...and Tat bind to TBP (19, 32), that YY1 physically interacts with Sp1 (34), ... See full document
11
Latency-Associated Nuclear Antigen Encoded by Kaposi's Sarcoma-Associated Herpesvirus Interacts with Tat and Activates the Long Terminal Repeat of Human Immunodeficiency Virus Type 1 in Human Cells
... with Tat is not abolished with the deletion ...site. One possibility was that LANA affects the basal transcrip- tional machinery in cooperation with Tat to influence HIV gene ...by Tat ... See full document
11
Interactions of the transcription factor AP-1 with the long terminal repeat of different human immunodeficiency virus type 1 strains in Jurkat, glial, and neuronal cells.
... (Table 1). The absence of AP-1 interaction with the lymphotropic LAI LTR is easily accounted for by the presence of two mutations within the TGACTCA consensus ...Moreover, one of the most ... See full document
9
Cooperation between herpes simplex virus type 1-encoded ICP0 and Tat to support transcription of human immunodeficiency virus type 1 long terminal repeat in vivo can occur in the absence of the TAR binding site.
... an only 4-fold increase over the basal level of CAT activity, while transfection with ICP0 resulted in a 27-fold ...the transcription of G6( 2 119)HIV-1LTR D TARCAT ...reporter, which lacks both the ... See full document
10
Repression in vitro, by human adenovirus E1A protein domains, of basal or Tat-activated transcription of the human immunodeficiency virus type 1 long terminal repeat.
... simian virus 40 (6, 31, 42), murine polyomavirus (6, 41), and human immunode- ficiency virus type 1 (HIV-1) (43, ...HIV long terminal repeat (LTR) promoter ... See full document
5
Differential role of long terminal repeat control elements for the regulation of basal and Tat-mediated transcription of the human immunodeficiency virus in stimulated and unstimulated primary human macrophages.
... 298-307 0022-538X/94/$04.00+0 Copyright ©D 1994, American Society for Microbiology Differential Role of Long Terminal Repeat Control Elements for the Regulation of Basal and Tat-Mediated[r] ... See full document
10
Human Immunodeficiency Virus cDNA Metabolism: Notable Stability of Two-Long Terminal Repeat Circles
... reverse transcription of the viral RNA to yield a linear double- stranded cDNA copy and then integration of the viral cDNA into a chromosome of the host ...in which it becomes circularized. In one ... See full document
9
Linker-scanning mutational analysis of the transcriptional activity of the human immunodeficiency virus type 1 long terminal repeat.
... LTR transcriptional activity obtained by using NXS mutants in Jurkat cells Spl, TATA, LBP-1, UBP-2 a NRE, Negative regulatory element; IL-2, interleukin-2; IL-2Ra, interleukin-2 receptor[r] ... See full document
9
The control of human immunodeficiency virus type 1 long terminal repeat promoter activity by retinoic acid
... can only activate transcription in vitro in the presence of partially purified TFIID, not with purified TBP ...Many transcription factors interact with the pre-initiation complex via TAFs ... See full document
171
Probing protein-DNA interactions at the long terminal repeat of human immunodeficiency virus type 1 by in vivo footprinting.
... A human binding site for transcription factor USF/MLTF mimics the negative regulatory element of human immunodeficiency virus type 1.. DNA binding factors that bind to the negative regul[r] ... See full document
5
Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides
... not only of the sequence-specific na- ture of polyamides and the specificity of the ChIP assay but they are also the first direct evidence that polyamides access chromatin and affect transcription factor ... See full document
6
Epstein-Barr virus nuclear antigen 2 transactivates the long terminal repeat of human immunodeficiency virus type 1.
... To identify the cis-regulatory sequences of the HIV-1 LTR target for EBNA2 activation, we performed cell transfection experiments in which the wild-type or mutant HIV-1 LTR plasmids carr[r] ... See full document
9
Chicken ovalbumin upstream promoter transcription factor binds to a negative regulatory region in the human immunodeficiency virus type 1 long terminal repeat.
... A Comparison of COUP-TF binding in HeLa nuclear extracts to COUP and HIV-1 variant COUP oligonucleotide probes by gel mobility shift analysis.. HeLa nuclear extracts N.E.[r] ... See full document
8
Naturally occurring genotypes of the human immunodeficiency virus type 1 long terminal repeat display a wide range of basal and Tat-induced transcriptional activities.
... One of these variants, containing a fourth Spi site, outgrew wild-type viruses containing three Spl sites when the two viruses were coculti- Transcripts with positive-strand polarity are[r] ... See full document
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