[PDF] Top 20 Impact of HLA-B*81-Associated Mutations in HIV-1 Gag on Viral Replication Capacity
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Impact of HLA-B*81-Associated Mutations in HIV-1 Gag on Viral Replication Capacity
... Replication Capacity Jaclyn K. Wright, a Vanessa L. Naidoo, a Zabrina L. Brumme, b,c Jessica ...Brockman, b,c Eric Hunter, d and Thumbi Ndung’u a,e HIV Pathogenesis Programme, Doris ... See full document
7
Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function
... of HLA-B*13 on HIV-1 disease progression are mediated in part by fitness costs of CTL escape mutations in conserved Gag epitopes, but other mechanisms remain incompletely ...the ... See full document
15
Effect on HIV 1 viral replication capacity of DTG resistance mutations in NRTI/NNRTI resistant viruses
... integration capacity of the mutational combinations studied in PM1 cells in com- parison to that of WT virus and viruses containing only single RT ...RT mutations or WT whereas DNA integration levels in ... See full document
10
Gag-Protease-Mediated Replication Capacity in HIV-1 Subtype C Chronic Infection: Associations with HLA Type and Clinical Parameters
... underlying HIV-1 control by protective HLA class I alleles are not fully understood and could involve selection of escape mutations in functionally important Gag epitopes resulting in ... See full document
12
Compensation by the E138K Mutation in HIV-1 Reverse Transcriptase for Deficits in Viral Replication Capacity and Enzyme Processivity Associated with the M184I/V Mutations
... nant HIV-1 NL4-3 viruses harboring E138K and M184I/V dou- ble mutations possessed high-level resistance to FTC and 3TC, as does the M184I/V single mutation, and possessed modest resistance to ETR, as ... See full document
9
HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition
... of HIV identified to date is expression of HLA-B57, but the mechanisms of this control remain ...analyzed viral sequences within and flanking the immuno- dominant and earliest targeted Gag CTL ... See full document
14
Early Selection in Gag by Protective HLA Alleles Contributes to Reduced HIV-1 Replication Capacity That May Be Largely Compensated for in Chronic Infection
... of HLA class I selection pressure on HIV-1 ...whereby HLA-associated CTL responses select for primary escape mutations in Gag during acute/early infection, some of which ... See full document
13
HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers
... (567 Gag, 392 RT, and 686 Nef) (7, 9). The median plasma viral load of CP was 120,000 (interquartile range, 42,000 to 310,000) RNA copies/ ...of HLA- associated polymorphisms in ... See full document
7
Lack of a significant impact of Gag Protease mediated HIV 1 replication capacity on clinical parameters in treatment naive Japanese individuals
... of Gag fitness as a major determinant of HIV-1 disease outcome in Japan, they do not completely exclude the possibility that Gag fitness subtly influences ...other mutations in ... See full document
14
Temporal Association of HLA-B*81:01- and HLA-B*39:10-Mediated HIV-1 p24 Sequence Evolution with Disease Progression
... and HLA-B*39:10 alleles have been associated with viremic control in HIV-1 subtype C ...p24 Gag, and cytotoxic-T-lymphocyte (CTL)-mediated escape mutations in this epitope ... See full document
12
Subtype associated differences in HIV 1 reverse transcription affect the viral replication
... the replication of ...subtype B and C viruses carrying fragments of the pol gene encod- ing the whole RT, distinct domains of RT, and the pro- tease or integrase sequences from different subtype C and ... See full document
18
Significant Reductions in Gag-Protease-Mediated HIV-1 Replication Capacity during the Course of the Epidemic in Japan
... type 1 (HIV-1) evolves rapidly in response to host immune selection ...of HIV-1 isolates from earlier in the epidemic may differ from those of isolates from later ...in viral ... See full document
12
HLA-Associated Alterations in Replication Capacity of Chimeric NL4-3 Viruses Carrying gag-protease from Elite Controllers of Human Immunodeficiency Virus Type 1
... reduced replication capacity at the time of transmission, rather than having these arise in ...the HLA-associated differences in VRC observed in the present ...protective HLA alleles ... See full document
10
Influence of Gag-Protease-Mediated Replication Capacity on Disease Progression in Individuals Recently Infected with HIV-1 Subtype C
... 2011 HLA class I-mediated selection of immune escape mutations in functionally important Gag epitopes may partly explain slower disease progression in HIV-1-infected individuals with ... See full document
11
High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control
... to HIV are confronted with difficulties in disentangling cause versus consequence of the tested ...selected HLA-B*27 epitope showing the gradual escape from high-avidity CTL responses ...ically ... See full document
12
Reduced Viral Replication Capacity of Human Immunodeficiency Virus Type 1 Subtype C Caused by Cytotoxic-T-Lymphocyte Escape Mutations in HLA-B57 Epitopes of Capsid Protein
... The major technical hurdle of the dual-infection assay is the requirement for differential quantification of two essentially isogenic viruses from a mixed sample. Our use of synonymous nucleotide substitutions to “tag” ... See full document
9
Pressure from TRIM5α Contributes to Control of HIV-1 Replication by Individuals Expressing Protective HLA-B Alleles
... and viral load for the 56 HIV-infected individuals eval- ...expressing HLA-B*57 and HLA-B*27 alleles. Viruses from HLA-B27 ⫹ controllers were intrinsically more sen- ... See full document
13
Intracellular HIV 1 Gag localization is impaired by mutations in the nucleocapsid zinc fingers
... intracellular Gag trafficking, and in virion assembly, we generated series of NC zinc fingers ...finger mutations have a negative impact on virion biogenesis and maturation and rendered defective the ... See full document
12
Spontaneous control of HIV 1 viremia in a subject with protective HLA B plus HLA C alleles and HLA C associated single nucleotide polymorphisms
... I/LW9 B*57 associ- ated epitope, restoring the original IW9 epitope with little or no impact on viral escape or fitness reported in prior ...of viral RNA in plasma, significant dif- ferences ... See full document
9
Spontaneous control of HIV-1 viremia in a subject with protective HLA-B plus HLA-C alleles and HLA-C associated single nucleotide polymorphisms
... I/LW9 B*57 associ- ated epitope, restoring the original IW9 epitope with little or no impact on viral escape or fitness reported in prior ...of viral RNA in plasma, significant dif- ferences ... See full document
9
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