[PDF] Top 20 CD4-Induced Conformational Changes in the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein: Consequences for Virus Entry and Neutralization
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CD4-Induced Conformational Changes in the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein: Consequences for Virus Entry and Neutralization
... the conformational changes in the HIV-1 gp120 glycoprotein induced by interac- tion with the CD4 receptor (54, 55, ...of CD4 binding is a property of envelope ... See full document
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Relationships between CD4 Independence, Neutralization Sensitivity, and Exposure of a CD4-Induced Epitope in a Human Immunodeficiency Virus Type 1 Envelope Protein
... the conformational changes initiated by receptor ...our CD4-independent Envs exhibit enhanced sensitivity to neutral- ization by all HIV-positive human sera we have tested indi- cates that the ... See full document
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Cyanovirin-N Binds to gp120 To Interfere with CD4-Dependent Human Immunodeficiency Virus Type 1 Virion Binding, Fusion, and Infectivity but Does Not Affect the CD4 Binding Site on gp120 or Soluble CD4-Induced Conformational Changes in gp120
... few human Abs are able to neutralize primary HIV isolates and many of these work only in a type-restricted manner, identifying ways to elicit Abs to the carbohydrate domains on the virion or identifying ... See full document
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Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1.
... for gp120 is contained within the CDR2-equivalent region of CD4 D1 (1, 2, 6, 10, 33, 39, 47, ...to CD4, the spike glycoproteins of HIV undergo a series of conformational changes ... See full document
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Mutagenic Stabilization and/or Disruption of a CD4-Bound State Reveals Distinct Conformations of the Human Immunodeficiency Virus Type 1 gp120 Envelope Glycoprotein
... to neutralization by antibodies (53, ...of gp120, which must be at least partly exposed on the virion surface, are potentially vulnerable to antibody-mediated ...the gp120 receptor-binding sites (51, ... See full document
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SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement
... viral entry, it creates major challenges for the expression and structural analysis of trimeric ...the gp120 and gp41 subunits (17–20), in combination with the helix-breaking isoleucine-to-proline change ... See full document
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Discovery of Small-Molecule Human Immunodeficiency Virus Type 1 Entry Inhibitors That Target the gp120-Binding Domain of CD4
... HIV-1 entry had actively been pursued for clinical applications long before the interaction of gp120-CD4 was ultrastructurally ...first entry inhibitor agents to be administered to ... See full document
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Determinants of human immunodeficiency virus type 1 entry in the CDR2 loop of the CD4 glycoprotein.
... of CD4 that are positioned proximal to the gp120 binding site (2, 3, 9, 12, 33, ...and gp120 binding affinity could explain the recep- tor capability of the mutant CD4 molecule, no evidence ... See full document
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Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody.
... ROBINSON' Received 23 August 1990/Accepted 12 October 1990 A human monoclonal antibody designated 15e is reactive with the envelope glycoprotein gpl20 of multiple isolates of human immun[r] ... See full document
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Envelope Conformational Changes Induced by Human Immunodeficiency Virus Type 1 Attachment Inhibitors Prevent CD4 Binding and Downstream Entry Events
... (Fig. 1), its photoactive analog, and the tritium- labeled inhibitors were prepared at Bristol-Myers Squibb ...line 1 of column 87 through line 49 of column 90. HIV-1 proviral DNA and isolates JRFL, ... See full document
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Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120.
... monomeric gp120 (52). All of the sequenced virus strains in the test panel, except IIIB, contained the canonical 19b epitope (Table ...Primary virus neutralizing activity shown by 19b at 100 m g/ml ... See full document
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Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4.
... We demonstrate that, at 37°C, the affinity of the binding reaction between sCD4 and HIV-1 IIIB and RF virions is experimentally indistinguishable from that for the reaction between sCD4 [r] ... See full document
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Inhibition of Human Immunodeficiency Virus Type 1 gp120 Presentation to CD4 T Cells by Antibodies Specific for the CD4 Binding Domain of gp120
... that gp120 in- teraction with the chemokine receptor CXCR4 caused endo- cytosis of gp120 and the coreceptors but that these molecules appeared to reach only the early endosomes and not ...Since entry ... See full document
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A human recombinant Fab identifies a human immunodeficiency virus type 1-induced conformational change in cell surface-expressed CD4.
... a human recombinant Fab library from the bone marrow of a human rsCD4-immunized, HIV-1-infected ...by human rsCD4 immunization of an HIV-1-infected human, we pro- duced a ... See full document
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CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor.
... Five plates of HeLa cells 5 x 105 cells per plate infected with vTF7-3 and transfected with pBS-G alone or both pBS-G and pBS-gpl60 were labeled for 10 min with 50 ,uCi of [35S]methionin[r] ... See full document
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Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein.
... To compare the ability of different gpl20 mutants to associate with the gp4l transmembrane glycoprotein, the levels of envelope glycoproteins in the lysates and supernatants of the trans[r] ... See full document
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A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells.
... Two other MAbs, OKT4 and L120, which are reactive with domains 3 and 4 of CD4, have little or no effect on HIV-1 infection, syncytium formation, or sCD4-induced conformational changes in[r] ... See full document
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Extent of Antigenic Diversity in the V3 Region of the Surface Glycoprotein, gp120, of Human Immunodeficiency Virus Type 1 Group M and Consequences for Serotyping
... Studies on HIV-1 diversity led to the identification of five major genetic subtypes within group M and at least 14 phen- etically associated groups (22, 36). The analysis of genetic relationships between isolates ... See full document
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Neutralization of Human Immunodeficiency Virus Type 1 by sCD4-17b, a Single-Chain Chimeric Protein, Based on Sequential Interaction of gp120 with CD4 and Coreceptor
... of neutralization of different HIV-1 iso- lates by MAbs and sCD4, there is a good correlation between neutralization activity and binding to the oligomeric Env ex- pressed on the virion surface (but ... See full document
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Interaction with CD4 and Antibodies to CD4-Induced Epitopes of the Envelope gp120 from a Microglial Cell-Adapted Human Immunodeficiency Virus Type 1 Isolate
... sCD4-induced gp120 shedding, we hypothesized that Bori and Bori-15 might differ in the affinity for ...Bori-15 gp120 and ...Bori-15 gp120 has a small but statistically significant lower ... See full document
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