[PDF] Top 20 Inflammatory IL 15 is required for optimal memory T cell responses
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Inflammatory IL 15 is required for optimal memory T cell responses
... of IL-15 in trafficking to inflamed tissues (11, ...sense IL-15 following viral infection would affect patho- gen control in the lymph ...WT memory P14 cells were adoptively transferred ... See full document
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Anti-Inflammatory Cytokines Directly Inhibit Innate but Not Adaptive CD8+ T Cell Functions
... the T cell receptor and through cytokine receptors results in the activation of a group of shared and distinct transcription factors that regulate T cell activation in a combina- torial ... See full document
11
Adjuvant IL 7 or IL 15 overcomes immunodominance and improves survival of the CD8+ memory cell pool
... If IL-7–mediated costimulation renders subthreshold peptide- TCR interactions sufficient for cells to undergo a proliferative burst, and if rhIL-15 enhances the size of the proliferative burst, one would ... See full document
12
Autoimmune melanocyte destruction is required for robust CD8+ memory T cell responses to mouse melanoma
... T cells provided durable tumor protection, were capable of mounting a rapid recall response to melanoma, and did not demonstrate phenotypic or functional signs of exhaustion even after many months of exposure to ... See full document
14
Effect of IL-7 and IL-15 on T cell phenotype in myelodysplastic syndromes
... of IL-15 expression has been detected in patients with autoimmune diseases and lymphoid ...malignancies. IL-15 overexpression can initiate leukemic transformation in murine models and that ... See full document
10
IL 15 induces CD4+ effector memory T cell production and tissue emigration in nonhuman primates
... for IL-15 therapy to exacerbate inflammatory disease in susceptible subjects (46) will have to be carefully monitored in treated subjects, as will its potential to enhance viral ...latter, ... See full document
12
Human Memory CD4+ T Cell Immune Responses against Giardia lamblia
... ⴙ T cell responses to ...(IL-17A), IL-10, and IL-4 was measured in CD4 ⴙ effector memory (EM) T cells after 24 h by flow ...of inflammatory cytokine levels ... See full document
8
Impact of IL-27 on regulatory T cell responses
... While IL-27 has not been used in any human therapies to date, the studies above illustrate the potential impact of IL-27 in clinical ...with IL-27 has had no adverse effects on the immune system ... See full document
203
Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes
... rapid-recall responses in vitro; survived for at least 10 weeks in vivo; and efficiently mounted a second- ary recall ...of IL-2 exhibited all the characteristics of effector ...of IL-2 and ... See full document
9
Peroxiredoxin II Regulates Effector and Secondary Memory CD8+ T Cell Responses
... immune responses. Taken as a whole, they argue that redox regulation of CD8 ⫹ T cell activation and differentiation is ...⫹ T cell responses in PrdxII ⫺/⫺ mice was not sustained, ... See full document
13
IL 6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
... of IL-6 in acute lung inflamma- tion, we first examined the content of cytokines including IL-6 and proinflammatory TNF a and MIP-2 in BAL in both IL-6 1 / 1 and IL-6 2 / 2 mice during acute ... See full document
11
Cd8+ T-Cell Responses in a Th2-Polarized Inflammatory Setting
... on IL-6 and an intact microbiota (288, ...as IL-2 or IL-4 to substitute for microbial ...mice, T cells may require little stimulation from foreign antigen to take on a memory ... See full document
116
IL 15 regulates memory CD8+ T cell O glycan synthesis and affects trafficking
... on T cells have, for the most part, been restricted to in vitro models of T cell activation ...is required to promote the generation of core 2 O-glycans, resulting in the formation of ... See full document
15
Cycling Memory CD4+ T Cells in HIV Disease Have a Diverse T Cell Receptor Repertoire and a Phenotype Consistent with Bystander Activation
... ⫹ memory T cells (25) as well as less dramatic cycling of naive T cells ...cycling memory CD4 ⫹ T cells remain elevated ...and T cell cycling fall rapidly with application ... See full document
12
Deletion of IL-4Rα on CD4 T cells renders BALB/c mice resistant to Leishmania major infection
... cre IL-4Ra /lox mice is CD4 þ T cell IL-4Ra– independent IL-4 ...in IL-4Ra / mice, IL-4Ra–independent IL-4 production has been observed in response to Nippos- ... See full document
11
IL 12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis
... Mice. All mice used in the current study were bred in the pathogen-free facility at the Braunwald Medical Research Center, in accordance with the guidelines of the committee of animal research at Harvard Medical School ... See full document
11
Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors
... T cell–directed immunotherapy has delivered remarkable therapeutic benefits in cancer ...cytotoxic T lymphocyte antigen 4 (CTLA-4) has proven efficacious in otherwise untreatable and aggressive ... See full document
12
Klein, Gerhardt (2017): Prävalenz der Interleukine IL-4, IL-8, IL-10 und IL-12 im Speichel bei Patienten mit chronischer Parodontitis und einer parodontitisfreien Probandengruppe sowie ihre Bedeutung als diagnostische Parameter. Dissertation, LMU München: Medizinische Fakultät
... dann entfalten, wenn das Immunsystem des Wirts bestimmte Voraussetzungen aufweist. Neben der direkten Schädigung des Parodontalgewebes triggern Virulenzfaktoren bestimmter Keime eine kaskadenartige und unkontrollierte ... See full document
196
Primer on tumor immunology and cancer immunotherapy
... immune responses involving T and B cells; and to initiate tissue ...Immune responses and in- flammation are generally advantageous for the host, and may include suppressing growth of smaller ... See full document
9
Antigen expression determines adenoviral vaccine potency independent of IFN and STING signaling
... CD8 T cell responses ...CD8 T cell immunity after rAd5 vaccination ...immune responses promote optimal CD8 T cell immunity after rAd vaccination, the in vivo ... See full document
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