[PDF] Top 20 Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Target Distinct Phases of Early Reverse Transcription
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Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Target Distinct Phases of Early Reverse Transcription
... of virus isolated from patients taking NVP ...commercial reverse transcriptase ELISA (Table ...vitro reverse transcrip- tion on a homopolymer template by recombinant HIV-1 RT than ... See full document
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Molecular Mechanisms by Which Human Immunodeficiency Virus Type 1 Integrase Stimulates the Early Steps of Reverse Transcription
... 5). Human immunodeficiency virus type 1 (HIV-1) IN is initially expressed and incorporated into the virus particle as a part of a Gag-Pol precursor ...including ... See full document
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Kinetic analysis of intravirion reverse transcription in the blood plasma of human immunodeficiency virus type 1-infected individuals: direct assessment of resistance to reverse transcriptase inhibitors in vivo.
... although reverse transcription may lead to degra- dation of viral RNA via RNase H, quantitation of HIV-1 virions by using gag primers with RT-PCR would not lead to spuriously low RNA levels, since ... See full document
7
Role of Vif in human immunodeficiency virus type 1 reverse transcription.
... stimulate reverse transcription or preceding early postentry ...affect reverse transcription, since in vitro studies have shown that the NC protein decreases the proba- bility of ... See full document
9
Effects of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Reverse Transcriptase Processing, Activity, and Drug Sensitivity
... three virus pairs studied here were characterized by a strong difference in infectivity between the pretherapy and post resistance protease-reconstructed molecular clones (20, ...for virus 487-post did we ... See full document
5
Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription.
... pol-encoded reverse transcriptase (RT) ...these early events prior to integration. For example, murine leukemia virus (MLV) DNA harvested from cells shortly after the initiation of infection ... See full document
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Resistance to Nucleoside Analog Reverse Transcriptase Inhibitors Mediated by Human Immunodeficiency Virus Type 1 p6 Protein
... drug target gene dosing associated with antimicrobial drug resistance in bacteria, parasites, and ...drug target, resistance in the parasite Leishmania donovani to methotrexate through dihydrofolate ... See full document
10
Characterization and Structural Analysis of Novel Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involved in the Regulation of Resistance to Nonnucleoside Inhibitors
... MDS. Our computational work started with the analysis of the available crystallographic unbound models of RT. The 1DL0 PDB model (22) was judged as the most complete (971 residues; resolution ⫽ 2.70 Å) and was selected ... See full document
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Genotypic, Phenotypic, and Modeling Studies of a Deletion in the β3-β4 Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene That Is Associated with Resistance to Nucleoside Reverse Transcriptase Inhibitors
... An important step in homology protein modeling experiments is the evalua- tion of the model quality. To ensure the quality, we used internal consistency checks as implemented in the software package MODELLER 4 (21) to ... See full document
7
HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells
... HIV-1 reverse transcription is based on its interaction with p66 RT rather than its inter- action with the HIV-1 ...preferred target cells for HIV infection, whereas unac- tivated T ... See full document
14
Frequency of Mutations Conferring Resistance to Nucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus Type 1 Infected Patients in Korea
... in early 1990, whereas the data in this study are based on long-term ZDV ...patients 1 and 11 in this study (Table 2), and a change from T69S to T69A was also detected in patient ... See full document
7
Immunogenicity of Mutations Induced by Nucleoside Reverse Transcriptase Inhibitors for Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Cells
... capacities of the wild-type (LAI) or mutated RT sequences. Six epitopes were predicted around each of the mutations M41L and L74V in the context of nine distinct HLA molecules (Fig. 1A and B). Mutation M41L ... See full document
7
Association of Human Immunodeficiency Virus Type 1 Vif with RNA and Its Role in Reverse Transcription
... are distinct from simpler retroviruses in encod- ing numerous regulatory proteins that modulate virus infectiv- ...of virus assembly by enabling the establishment of integrated provirus in new ... See full document
8
Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... ⫺ 1, ⫺ 2, and ⫹ 1 frameshift mutations and dislocation mutagenesis of HIV-1 RT ...the early phase: check of base pair geometry at initial binding of substrate and check of steric hindrance ... See full document
13
The importance of the A-rich loop in human immunodeficiency virus type 1 reverse transcription and infectivity.
... DNA sequencing of the A-rich loop region of long-term-cultured mutated viruses. MT-2 cells infected by mutated HIV/del-A, which had been treated with RNase-free DNase I, were maintained in supplemented RPMI 1640 medium. ... See full document
8
Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription Complex
... Reverse transcription is catalyzed by RT, and although re- verse transcription can occur in vitro with recombinant RT, template, and primer, the process is more complex in ...replicating ... See full document
10
Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
... processing of Gag-Pol and/or Gag (1, 16, 21), we considered the possibility that the point mutations affected the folding of Gag-Pol. However, the amount of PR and IN is normal or near normal in our mutants, ... See full document
9
Cell Factors Stimulate Human Immunodeficiency Virus Type 1 Reverse Transcription In Vitro
... and reverse tran- scription products were detected in the ...strong-stop reverse transcription products was detected (peak R in ...strand transcription products was greatly increased by the ... See full document
13
Cross-Linking of the Fingers Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Template-Primer
... HIV-1 RT mutants were created that had the cysteines nor- mally present at positions 38 and 280 replaced (by valine and serine, respectively) and also had a single cysteine residue introduced into specific ... See full document
11
Inhibition of -Primed Reverse Transcription by Human APOBEC3G during Human Immunodeficiency Virus Type 1 Replication
... both early minus-strand strong stop DNA synthesis ...reduce early and late DNA synthesis, although not as strongly as the reductions due to full-length ... See full document
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