[PDF] Top 20 Early versus late initiation of renal replacement therapy in patients with acute kidney injury-a systematic review & meta-analysis of randomized controlled trials

... and acute pulmonary edema due to fluid overload responsible for severe hypoxemia requiring an oxygen flow rate greater than 5 l per minute to maintain a peripheral capillary oxygen saturation (Sp o2) greater than ... See full document

... Background: Acute kidney injury remains a common complication in critically ill patients and despite multiple trials and observational studies, the optimal timing for initiation ... See full document

... AKI patients with traditional indications, the advantages of commencing RRT in the absence of life-threatening complications are still under controversial ...that early initiation of RRT is related ... See full document

... our analysis to studies meeting high-quality criteria, we dismissed a large volume of research on this ...these trials is less controversial than our decision to exclude cohort trials for an NOQA ... See full document

... RRT initiation has been evaluated in different population types ...previous systematic analyses regarding the optimal tim- ing of RRT initiation were unable to draw definitive con- clusions owing to ... See full document

... in patients with AKI were selected for further ...Full-text review was independently performed by two reviewers (as above) for the following specific elig- ibility criteria: 1) observational cohort and/or ... See full document

... and late RRT were defined on the basis of different criteria reported by the authors in their original research; we accepted a broad definition of early and late RRT and categorized this by time ... See full document

... continuous renal replacement therapy (CRRT) in AKI based on the findings of these two ...prospective, randomized, parallel group trial of two strategies for RRT in critically ill ... See full document

... five randomized controlled trials (RCTs) and reported a significant survival benefit when RRT was started ...a meta-analysis of 13 observational studies and two small ...the ... See full document

... pilot randomized controlled trial (RCT), we dem- onstrated the feasibility and safety of conducting a trial comparing early versus standard RRT using FST as an initial triage ...nonresponsive ... See full document

... with patients with AKI, with or without sepsis, suggest on the contrary that there may be a benefit to early initiation of RRT ...A meta-analysis published in 2008 by Seabra [18], which ... See full document

... upregulated early in the course of AKI ...tween patients whose elevated serum creatinine values are due to established acute kidney damage (that is, the target population for this trial) ... See full document

... this systematic review and meta-analysis lied in the instruction significance for clinical question, large volume of data included and rigorous methodology ...for acute kidney ... See full document

... functional renal impairment and less histologic damage after ischemia-reperfusion ...the renal hemodynamic response to angiotensin II have been demonstrated in experimental models and in human ... See full document

... ill patients. We can only extrapolate data from patients with isolated AKI due to acute decompensated heart failure to cur- rent ICU ...earlier trials constitutes an important limitation in ... See full document

... prospective randomized controlled trials (RCTs) have directly compared the different ap- proaches ...whole, meta-analysis of available data did not demonstrate a gen- eral survival ... See full document

... with acute febrile illness like fever, generalized body pain, loose stools, vomiting, swelling of legs, generalized swelling of the body, decreased urine output, breathlessness, cough, chest pain, altered ... See full document

... medical therapy (MT) which uses antico- agulants, such as thrombolytic, beta blocker, calcium blocker, antiarrhythmic, nitrates, diuretics, antiplatelet, and lipid regulating drugs; (B) percutaneous coronary ... See full document

... combined initiation and dis- continuation of antibiotics, we found no beneficial effect with regard to any predefined ...two trials (one positive [35] and one negative [38]) investigated the combined strat- ... See full document

... and acute PA studies are designed with different parameters and considerations in ...blinding, acute PA studies may not have incorporated blinding in their study design either due to funding or because it ... See full document