[PDF] Top 20 HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells
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HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells
... silencing HuR expression with three different siRNAs targeting three different sites in the HuR mRNA sequence, we demonstrated that HuR expression was required for an optimal HIV-1 replication ... See full document
14
Mutations That Abrogate Human Immunodeficiency Virus Type 1 Reverse Transcriptase Dimerization Affect Maturation of the Reverse Transcriptase Heterodimer
... intracellular reverse transcription, particularly for the W401A mutants, is that the RT may behave differently on an artificial template/primer from how it behaves when presented with the natural tRNA Lys ... See full document
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Human immunodeficiency virus type 1 Nef increases the efficiency of reverse transcription in the infected cell.
... Nef 1 and Nef 2 isogenic human immunodeficiency virus in CEM, HUT78, MT4 lymphoid, and U937 monocytic cell ...of infected cells, we have assessed the relative infectivity of the ... See full document
7
Kinetic analysis of intravirion reverse transcription in the blood plasma of human immunodeficiency virus type 1-infected individuals: direct assessment of resistance to reverse transcriptase inhibitors in vivo.
... Intravirion reverse transcripts have been identified in the blood plasma of human immunodeficiency virus type 1 (HIV-1)-infected ...HIV-1 reverse ... See full document
7
Requirement for Integrase during Reverse Transcription of Human Immunodeficiency Virus Type 1 and the Effect of Cysteine Mutations of Integrase on Its Interactions with Reverse Transcriptase
... IN interacts with RT is consistent with the requirement for IN during reverse ...support reverse transcription in vivo are incapable of interacting with RT in ...of reverse transcrip- ... See full document
11
Subunit-Specific Analysis of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase In Vivo
... p66 complex. Our analysis showed that cleavage by the viral protease liberates Vpr and generates functional heterodimeric RT (p51/p66) that supports HIV-1 reverse transcription and virus ... See full document
8
Characterization of Intracellular Reverse Transcription Complexes of Human Immunodeficiency Virus Type 1
... of virus internalization, while MoMLV cores per- sist longer inside the infected cells (15, ...isolated 1, 4, and 7 h after acute infection were competent for DNA synthesis in ...about ... See full document
10
Human Immunodeficiency Virus type 1 reverse transcriptase exists as post translationally modified forms in virions and cells
... the infected cell, or may play a role in important structural interactions required for stability, movement and activity of the RTC ...cell-free virus and 2D gel analysis, as would be necessitated in these ... See full document
12
Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
... of virus to ...from infected PBMC at day 7 showed that while the mutation to GTA at codon 74 was retained in lower virus dilutions (1:16, 1:64, and 1:256), a mixture of WT (TTA) ... See full document
7
Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... of cells with drug treatment) ⫻ luciferase reading of drug-treated cells]/luciferase reading of cells with no drug treatment} ⫻ (viral titer of virus with no drug treatment/viral titer of ... See full document
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The importance of the A-rich loop in human immunodeficiency virus type 1 reverse transcription and infectivity.
... HIV-1 reverse tran- scription can also be inferred from in vivo ...on virus replication ...in infected cells, resulting in reduced infectiousness of the mutated viruses, ...in ... See full document
8
Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription Complex
... replicating virus but independently from that of Gag-Pol, we used an approach developed in our laboratory for incorporating proteins into HIV virions by their expression in trans as fusion partners of either Vpr ... See full document
10
Influence of Reverse Transcriptase Variants, Drugs, and Vpr on Human Immunodeficiency Virus Type 1 Mutant Frequencies
... on virus mutant frequen- cies could not be readily determined (Table ...during reverse transcription. Recent struc- tural studies of HIV-1 RT complexed with a polypurine track- containing ... See full document
10
Inhibition of -Primed Reverse Transcription by Human APOBEC3G during Human Immunodeficiency Virus Type 1 Replication
... 293T cells expressing hA3G (lane ...in cells infected with Vif-negative virions exposed to ...-primed reverse transcription was reflected in the synthesis of minus- strand strong stop ... See full document
13
Association of Human Immunodeficiency Virus Type 1 Vif with RNA and Its Role in Reverse Transcription
... of human immunodeficiency virus type 1 (HIV-1) is essential for viral replication, although the functional target of Vif remains ...H9 cells dis- played no significant ... See full document
8
Functional Domains of Tat Required for Efficient Human Immunodeficiency Virus Type 1 Reverse Transcription
... independent virus stocks and suggest that the ability of tat to efficiently initiate HIV-1 reverse transcription is largely dependent on an intact Tat amino ...HIV-1 reverse ... See full document
10
Reverse Transcriptase Inhibitors Can Selectively Block the Synthesis of Differently Sized Viral DNA Transcripts in Cells Acutely Infected with Human Immunodeficiency Virus Type 1
... of human immunodeficiency virus type 1 (HIV-1) reverse transcription by inhibitors of reverse transcriptase (RT) occurred most efficiently when the ... See full document
8
Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Target Distinct Phases of Early Reverse Transcription
... In the present study, NERT-PCR assays discriminated be- tween the anti-initiation and antielongation effects on viral DNA synthesis of PFA, ddATP, NVP, and RA and indicated that both NVP and RA directly targeted very ... See full document
10
Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1.
... We constructed a series of BspMI cassettes that simplify the introduction of specific point mutations in the polymerase domain of human immunodeficiency virus type 1 reverse transcriptas[r] ... See full document
9
Human Immunodeficiency Virus Type 2 Reverse Transcriptase Activity in Model Systems That Mimic Steps in Reverse Transcription
... Our results demonstrate that, in general, the polymerase and RNase H activities of the HIV-1 and HIV-2 enzymes give similar results in quantitative functional assays. However, un- der conditions where the RT ... See full document
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