[PDF] Top 20 Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding.
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Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding.
... conformation-sensitive epitopes on the native HIV-1 gp120 ...These epitopes, for example, are completely disrupted in some buffers containing ionic detergents that do not affect the integrity ... See full document
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The Human Immunodeficiency Virus Type 1 gp120 V2 Domain Mediates gp41-Independent Intersubunit Contacts
... An involvement of the V2 loop in the gp120 intersubunit contact site is also consistent with a number of reports sug- gesting that epitopes within this domain are less accessible to MAb ... See full document
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Cooperation of the V1/V2 and V3 Domains of Human Immunodeficiency Virus Type 1 gp120 for Interaction with the CXCR4 Receptor
... the gp120 core (30) allowed definition of a CCR5-binding site formed by juxtaposition of residues from different conserved domains ...of gp120 also participate in the interaction with CXCR4. Regions ... See full document
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Loss of a Single N-Linked Glycan Allows CD4-Independent Human Immunodeficiency Virus Type 1 Infection by Altering the Position of the gp120 V1/V2 Variable Loops
... ADA gp120 for CCR5 in the absence of ...conserved V1/V2 stem, which consists of two antiparallel strands linked at both ends by disulfide ...The V1 and V2 variable loops, which ... See full document
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Enhanced Exposure of the CD4-Binding Site to Neutralizing Antibodies by Structural Design of a Membrane-Anchored Human Immunodeficiency Virus Type 1 gp120 Domain
... of gp120 in both CD4-bound and b12-bound ...dual-tropic virus, R3A, was selected as a prototype (20). Laboratory-adapted virus strain R3A TA1 contains a truncated V1/V2 and a truncated ... See full document
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Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein.
... the V1 and V2 loops has been shown to increase the exposure of the CD4i epitopes on the monomeric HIV-1 gp120 glycopro- tein ...with V1 and V2 deleted to ... See full document
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Identification of Conserved and Variable Structures in the Human Immunodeficiency Virus gp120 Glycoprotein of Importance for CXCR4 Binding
... of human immunodeficiency virus type 1 (HIV-1) into target cells requires the fusion of the viral and cellular membranes ...the virus to be delivered into the cytoplasm of ... See full document
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Structural modulations of the envelope gp120 glycoprotein of human immunodeficiency virus type 1 upon oligomerization and differential V3 loop epitope exposure of isolates displaying distinct tropism upon virion-soluble receptor binding.
... for binding to the gp120 monomers, the half-maximal binding values of the anti- CD4-binding site MAbs tested with the virion surfaces of both macrophage- and T-cell line-tropic isolates were ... See full document
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Evidence for Similar Recognition of the Conserved Neutralization Epitopes of Human Immunodeficiency Virus Type 1 Envelope gp120 in Humans and Macaques
... envelope gp120, among which are the CD4 binding site (CD4BS) (7, 23, 45); the variable V1, V2, and V3 loops; a gp120 structure that is near the chemokine recep- tor ... See full document
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Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution
... The human immunodeficiency virus type 1 envelope glycoprotein (Env) complex is the principal focus of neutralizing antibody-based ...three gp120 molecules and three gp41 ... See full document
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Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds
... the binding of both CD4i MAbs 17b and 4C11 increased remarkably after pretreatment with 100 M NBD-556 (the MFIs increased from ...the binding of all of the anti-V3 MAbs—KD-247, 3E4, and ...the ... See full document
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Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120.
... Both the linear V2 and conformation-dependent V1V2 MAbs bind well to gpl2O expressed at the surface of infected cells Table 3, suggesting that this region of the envelope is well exposed[r] ... See full document
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Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody.
... 3674-3679 0022-538X/93/063674-06$02.00/0 Copyright © 1993, American Society for Microbiology Effect of Amino Acid Changes in the V1/V2 Region of the Human Immunodeficiency Virus Type 1 g[r] ... See full document
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Antigenic Variation within the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120: Effects on Chemokine Receptor Utilization
... expressing gp120 ORFs of several molecularly cloned laboratory-adapted viruses maintain the tropism of the gp120-derived clone and demonstrate the same sensitivity to neutralizing agents as the ... See full document
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Interaction with CD4 and Antibodies to CD4-Induced Epitopes of the Envelope gp120 from a Microglial Cell-Adapted Human Immunodeficiency Virus Type 1 Isolate
... leukemia virus (MLV) ...either human CD4 or CCR5 expression vectors or an empty vector as a negative ...linear epitopes of CD4 (AF-379-NA; R&D Systems, Minneapolis, MN) and CCR5 (CTC8; R&D ... See full document
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Identification of the Optimal DC-SIGN Binding Site on Human Immunodeficiency Virus Type 1 gp120
... wild-type gp120-Fc in its sensitivity to mannan competition during cell surface DC-SIGN and sol- uble DC-SIGN (ECD) binding ...DC-SIGN binding; one or more N-glycan sites mutated in the 134mut ... See full document
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Molecular mimicry between the human immunodeficiency virus type 1 gp120 V3 loop and human brain proteins.
... Western blot immunoblot analysis of the brain proteins was performed with several monoclonal and polyclonal anti-HIV-1 antibodies including polyclonal rabbit anti-HIV-1 gp120 American Bi[r] ... See full document
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Synergistic neutralization of human immunodeficiency virus type 1 by a chimpanzee monoclonal antibody against the V2 domain of gp120 in combination with monoclonal antibodies against the V3 loop and the CD4-binding site.
... of virus which it does not significantly neutralize ...in gp120 upon binding of one or both MAbs may result in increased affinity or exposure of the epitope of one or both MAbs, as has ... See full document
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Analysis of the Critical Domain in the V3 Loop of Human Immunodeficiency Virus Type 1 gp120 Involved in CCR5 Utilization
... V3 loop differs from that of ADA at eight positions (amino acid residues 283, 285, 287, 290, 291, Gln and Arg [QR] insertion, and residue 289 ...V3 loop required for CCR5 ...Fig. 1). A unique AatII ... See full document
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Single-Molecule Analysis of Human Immunodeficiency Virus Type 1 gp120-Receptor Interactions in Living Cells
... of gp120-receptor complexes have provided invaluable details about the structure of the HIV-1/ cell binding interface at the atomic level (22, 33, 41, 42), but the actual details of the ... See full document
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