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1 The Janus Face of NKT Cell Function in
... anti-inflammatory functions of different subsets of CD1d-restricted natural killer T cells during 369. Trypanosoma cruzi infection[r] ... See full document
11
Herpes Simplex Virus 1 Glycoprotein B and US3 Collaborate To Inhibit CD1d Antigen Presentation and NKT Cell Function
... type 1 (HSV-1) rapidly and efficiently downregulates the major histocompati- bility complex class I-like antigen-presenting molecule, CD1d, and potently inhibits its recognition by CD1d- restricted natural ... See full document
12
Metabolism and hydrophilicity of the polarised ‘Janus face’ all cis tetrafluorocyclohexyl ring, a candidate motif for drug discovery
... hydrogen face of the cyclohexane (panels A and ...uorine face (panels C and D and E and ...hydrogen face and water in this region makes additional favourable contributions to the hydration free ... See full document
6
Dietary arachidonic acid: a Janus face actor in brain and Alzheimer’s disease?
... Neurofibrillary tangles are formed by aggregation of hyperphosphorylated tau protein filaments while amyloid plaques result from aggregation of amyloid-b [Ab] peptide (Fig. 1). Tau protein physiologically associates ... See full document
8
The janus face of race: Rhonda M Williams on orthodox economics schizophrenia
... "'Race, Culture, and Skill: Interracial Wage Differences Among African Americans, Latinos, and Whites." Review of Black Political Economy 253 Winter 1997: 5-40.. "The Divide-and-Conquer [r] ... See full document
14
Unmasking the Janus face of myoglobin in health and disease
... to chronic hypoxic conditions, an increase of myoglobin expression could not be observed as a consequence of oxygen deprivation as the sole stimulus, and no link to an involvement of HIF-1 has been recognized ... See full document
7
Transcriptional analysis of natural killer T cell development
... of NKT cells engages its ligand, CD1d-lipid co-complex, with conserved germline-encoded residues in four-to-five of the six complementarity-determining regions of the combined TCR α- and β-chains (Rossjohn et ... See full document
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NKT cell–dependent leukemia eradication following stem cell mobilization with potent G CSF analogs
... hepatic NKT cell population and enhances functional responses to ...stem cell transplantation, donor NKT cells promoted host DC activation and enhanced perforin-restricted CD8 + T cell ... See full document
12
Greater Expansion of IFN γ﹣ CD4+ NKT Cells in HIV 1 Compared with HIV 2 Infected Subjects with Preserved CD4+ T Cell Counts
... than 1% of the total lymphocyte population [2] and a significant proportion express conserved invariant T cell receptor chains that distinguished them from T lymphocytes: this subset of NKT cells ... See full document
6
TIM-4 is expressed on invariant NKT cells but dispensable for their development and function
... TIM-4, also named as SMUCKLER (spleen, mucin- containing, knockout of lymphotoxin), was originally identified by gene expression profiling in 2004 [22]. Being the sole TIM member absent in conventional T cells, TIM-4 was ... See full document
13
NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human
... immune cell homeostasis as well as peripheral immune function ...T cell lymphomas (2, ...NK, NKT, and CD8 memory cell populations (referred to here as polyclonal IL-15tg ...blood ... See full document
16
Frequency and Phenotype of Circulating Vα24/Vβ11 Double-Positive Natural Killer T Cells during Hepatitis C Virus Infection
... disturbance of homeostatic cytokines. Further analysis of the function of these cells and studies of intrahepatic phenotype and distribution are clearly important. While it is not generally required, as we have ... See full document
7
Testing the NKT cell hypothesis of human IDDM pathogenesis
... to 1% of the ...of NKT cells in autoimmune ...the NKT cell defect through overexpression or cell transfer (16, ...the NKT defect by introduction of a germline deletion of CD1d ... See full document
9
Role of janus kinase inhibitors in the treatment of alopecia areata
... function, which in turn phosphorylates STAT component. Phosphorylation of the STAT component dimerizes and activates STATs. The activated STATs then will, in turn, translocate to the DNA in the nucleus and promote ... See full document
13
Modulation of NKT cells and Th1/Th2 imbalance after α-GalCer treatment in progressive load-trained rats
... cell function is related to the emergence of exer- cise-induced immunosuppression [4, ...concerning NKT cells is that they may be able to display flexibility in their cytokine ...specific NKT ... See full document
6
Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?
... I NKT cells are present in different tissues, such as the spleen (0,2-0,5% of the T lymphocytes), bone marrow, thymus, lymph nodes and blood (0,01-0,5% of the T lymphocytes) in mice [12, ...the NKT cells ... See full document
13
Scavenger receptors target glycolipids for natural killer T cell activation
... by cell-surface receptors could therefore either indicate the direct recognition of the lipid antigen itself (Figure 3) or rather reflect a preferential association of certain lipid structures with par- ticular ... See full document
13
Analysis of Dry Cutting in the Process of Face Milling
... Za prakso j e obvladovanje procesa odrezovanja zelo pom em bno. Z uvajanjem zahtevnih obdelovalnih sistemov se je povečala zahteva po zanesljivih tehnoloških informacijah [1 j. To terja seveda zanesljivo analizo ... See full document
7
Multipotent stem cells in the Malpighian tubules of adult Drosophila melanogaster
... via cell rearrangements and, eventually, cell differentiation (Ainsworth et ...tubule cell fate (see Hatton-Ellis et ...tubule cell-shape changes, and the rearrangement of the cycloskeleton ... See full document
11
Histone demethylases UTX and JMJD3 are required for NKT cell development in mice
... in NKT development observed in Tbet KO mice occurs at the P2 to P3 transition while loss of UTX and JMJD3 causes an earlier ...Tbet function in NKT cells as seen in other systems, the developmental ... See full document
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