[PDF] Top 20 Liberal versus restrictive red blood cell transfusion strategy in sepsis or septic shock: a systematic review and meta analysis of randomized trials

... TRICC trials, even though use of a re- strictive transfusion threshold of < 80 g/L may not be safe in patients with underlying acute coronary syn- drome or chronic cardiovascular disease ...As sepsis ... See full document

... with sepsis and septic ...in sepsis, through targeting the inflammatory ...a systematic review (SR) with network meta-analysis (NMA) to compare the different treatments ... See full document

... and blood compo- nent removal’ (Additional file ...included trials and relevant reviews in Scopus to identify additional ...planned trials, we searched the World Health Organization’s International ... See full document

... APACHE II Acute Physiology and Chronic Health Evaluation II, ARDS acute respiratory distress syndrome, EN enteral nutrition, EPA eicosapentaenoic acid, GLA gamma linolenic acid, ICU intensive care unit, LCT long-chain ... See full document

... with sepsis is important for both therapeutic and prognostic ...atic review and meta-analysis of studies of adult patients requiring ICU care, adjusted mortality was reduced with overweight ... See full document

... Statistical analysis The statistical calculations were done with the freely available software R [20] using the R package meta ...a meta-analysis is an observational study, the statistical ... See full document

... in sepsis is well established in the ...with sepsis. A variety of small open-label clinical trials have been published with gener- ally promising ...those trials inherit a high risk of bias, ... See full document

... our meta-regression may have been susceptible to outlier ...our meta-regression analyses were conducted based to on three ...Our analysis did not show this ...with sepsis enrolled in usual ... See full document

... study yielded a less precise result (mean difference of 9 days, 95% CI −3.64 to 21.6 days). Discussion This NMA has provided no clear evidence that any one intervention or treatment regimen is better than any other ... See full document

... included randomized trials SourceInterventionsOutcome Hemodynamic variablesOrgan function/metabolic parametersMortalityCardiac adverse events Mahmoud and ammar11ne+DB vs ne+enne+en is more effective than ... See full document

... for Systematic Reviews and Meta-Analyses) statement meth- odology [18] to report, a systematic review and meta- analysis of ...journals. Trials were consid- ered without ... See full document

... the sepsis bundle due to its definite survival benefit, and its clin- ical efficacy was established via subsequent ...severe sepsis. 4,5,22 Investiga- tors who published the latest meta-analyses, ... See full document

... the Sepsis-3 definition of septic shock, we need more detailed and standardized reporting of ...electronic septic shock dataset for all large-scale RCTs would improve the clinical ... See full document

... Competing interests JAR reports receiving consulting fees from Ferring Pharmaceuticals. There was no financial support for the manuscript. JAR reports holding stock in the University of British Columbia, which has ... See full document

... with Sepsis-3 definitions was considered a potential source of het- erogeneity given the more narrowly defined, more se- vere patients these criteria would identify with the addition of this ...except ... See full document

... clinical trials examining this issue provide no clear guidance in deciding when small preterm infants should receive RBC ...more liberal transfusion was associated with less frequent severe apnea in ... See full document

... The results of this trial should be interpreted with cau- tion, since the planned inclusion of 1,600 patients was not achieved due to slow recruitment. The patient popu- lation may not be representative for ICU patients ... See full document

... Our meta-analysis summarized all randomized controlled trials which are relevant to the com- parison on restrictive transfusion with liberal transfusion treatment ... See full document

... RBC transfusion in anemic patients undergoing cardiac surgery. This meta-analysis has several ...the restrictive RBC transfusion strategies varied between the ...to restrictive ... See full document

... Data extraction Two independent reviewers extracted the data using a pre-de ned extraction table. Any disagreements were resolved through discussion with a third clinician until the consensus was reached. The study ... See full document