[PDF] Top 20 Localization of HIV 1 Vpr to the nuclear envelope: Impact on Vpr functions and virus replication in macrophages
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Localization of HIV 1 Vpr to the nuclear envelope: Impact on Vpr functions and virus replication in macrophages
... the vpr gene of the macrophage-tropic HIV-1YU-2 molec- ular ...isogenic vpr- defective mutant HIV-1YU-2∆Vpr, which contains two stop codons in frame without altering the vif open ... See full document
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Nuclear Export of Vpr Is Required for Efficient Replication of Human Immunodeficiency Virus Type 1 in Tissue Macrophages
... ular HIV clone to infect lymphoid histocultures derived from human tonsil or spleen tissue, we found that the limited incor- poration of the Vpr L67A mutant into virions reduced the number of infected ... See full document
8
Novel Nuclear Import of Vpr Promoted by Importin α Is Crucial for Human Immunodeficiency Virus Type 1 Replication in Macrophages
... immunodeficiency virus type 1 (HIV-1) ...of HIV-1 enters the nuclei of monocyte-derived macrophages, but very little PIC migrates into the nuclei of immature ...monocytes. ... See full document
10
Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation.
... six HIV-1 auxiliary proteins (Vif, Vpr, Tat, Vpu, Rev, and Nef), Vpr is the only gene product that is incorporated efficiently into the progeny virions (6, ...of Vpr in the virions is a ... See full document
13
Vpr of simian immunodeficiency virus of African green monkeys is required for replication in macaque macrophages and lymphocytes.
... immunodeficiency virus type 1 (HIV-1) ...designated vpr and vpx, which in combination appear to share the functions of HIV-1 ...of HIV-1 vpr, ... See full document
10
Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Functions as an Immediate-Early Protein during HIV-1 Infection
... immunodeficiency virus type 1 (HIV-1) Vpr is a virion-associated protein which facilitates HIV-1 infection of nondividing cells by contributing to the nuclear ... See full document
9
Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.
... immunodeficiency virus type 1 Vpr is a virion-associated, regulatory protein that is required for efficient viral replication in ...cells, Vpr localizes to the nucleus. Recently, we ... See full document
8
Proline 35 of Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Regulates the Integrity of the N-Terminal Helix and the Incorporation of Vpr into Virus Particles and Supports the Replication of R5-Tropic HIV-1 in Human Lymphoid Tissue Ex Vivo
... immunodeficiency virus type 1 (HIV-1) Vpr reveals that only Pro-35 is required for efficient replication of R5-tropic, but not of X4-tropic, viruses in human lymphoid tissue ... See full document
5
Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Enhances Expression from Unintegrated HIV-1 DNA
... nodeficiency virus type 1 (HIV-1) replication and may play a significant role in HIV-1 ...pathogenesis. HIV-1 Vpr is a virion-associated accessory ... See full document
11
Human Immunodeficiency Virus Type 1 Vpr Induces DNA Replication Stress In Vitro and In Vivo
... immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) causes cell cycle arrest in G 2 .... Vpr-expressing cells display the hallmarks of certain forms of DNA damage, ... See full document
12
Two Putative α-Helical Domains of Human Immunodeficiency Virus Type 1 Vpr Mediate Nuclear Localization by at Least Two Mechanisms
... cell, HIV has evolved specific mechanisms that are independent of the breakdown of the nuclear ...mainly Vpr and, to some extent, MA (10, ...by HIV of nondividing cells, such as ... See full document
8
Nucleocytoplasmic Shuttling by Human Immunodeficiency Virus Type 1 Vpr
... immunodeficiency virus type 1 (HIV-1) is capable of infecting nondividing cells such as macrophages because the viral preintegration complex is able to actively traverse the limiting ... See full document
11
HIV 1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic intervention
... infecting macrophages with HIV-1 viruses that were Vpr WT, ATG-Vpr (Vpr negative), Vpr R62P (impaired in nuclear localization), and Vpr R80A (impaired ... See full document
20
Importin-α Promotes Passage through the Nuclear Pore Complex of Human Immunodeficiency Virus Type 1 Vpr
... immunodeficiency virus type 1 has potent karyophilic properties, but details of the mechanism by which it enters the nucleus remain to be ...the nuclear localization of ...the nuclear ... See full document
8
HIV-1 Vpr Oligomerization but Not That of Gag Directs the Interaction between Vpr and Gag
... cellular localization of Vpr depends upon that of Pr55 Gag ...whether Vpr oligo- merization and Pr55 Gag multimerization were required for their mutual recognition during virus ...tagged ... See full document
12
The HIV-derived protein Vpr
... the HIV-derived protein Vpr induces apoptosis in glioma cells, acts independently from MGMT expression status, is tolerated well when given intravenously, delays intracranial tumor growth and prolongs ... See full document
13
Antisense phosphorothioate oligodeoxynucleotides targeted to the vpr gene inhibit human immunodeficiency virus type 1 replication in primary human macrophages.
... Thus, HIV-1 replication in human macrophages is modulated by the expression of the vpr gene, and it is conceivable that vpr antisense oligodeoxynucleotides could be used in combination w[r] ... See full document
6
HIV-1 Vpr Redirects Host Ubiquitination Pathway
... IMPORTANCE HIV-1 is known to rely heavily on modulation of the host ubiquitin pathway, particularly for counteraction of antiretroviral re- striction factors, ...by HIV-1 at the level of E3 ... See full document
12
Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex
... (Fig. 1), we could not discern any marked accumulation of this protein at the nuclear envelope (data not ...of HIV-1 Vpr with nucleoporins. Having shown that Vpr can ... See full document
10
Nuclear Export of Human Immunodeficiency Virus Type 1 Vpr Is Not Required for Virion Packaging
... of HIV-1 gene expression in host cells remains to be ...of Vpr shuttling? Although resolution of this issue awaits further experimentation, it is tempting to speculate that the nucleocytoplasmic ... See full document
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