[PDF] Top 20 Long Noncoding RNA: Recent Updates in Atherosclerosis

... MALAT1 was firstly identified in lung cancer [61]. Later, increased MALAT1 levels are found in several other types of tumours and overexpression of MALAT1 results in proliferation and metastasis [62, 63]. Recent ... See full document

... uncharacterized long noncoding RNA, nexilin F-actin binding protein antisense RNA 1 (NEXN-AS1), modulates the expression of the actin-binding protein NEXN and that NEXN exerts a protective ... See full document

... Several lncRNAs have been shown to be involved in spe- cific physiological and pathological processes [5, 8], as well as in cardiovascular diseases [9–16]. We identified 14 lncRNAs deregulated in non end-stage HF ... See full document

... Another caveat is that there is a potential problem of alignment reliability especially for noncoding regions. Orthologous sequences are often inferred across organisms by alignment of two or more sequences and ... See full document

... of RNA–DNA triplexes ...for noncoding RNAs produced in the pro- moter of ribosomal RNAs, which, by forming local triple-helix structures, can recruit the DNA methyltrans- ferase DNMT3b and induce silencing ... See full document

... among recent contacts comprises a clinical evaluation by a physician specializing in pulmonary diseases, a chest X-ray (CXR), and a tuberculin skin test ...and long-term (lt) ...had recent close ... See full document

... Despite recent advances in treatment, the prognosis, particularly for those at the advanced stages, remains ...that long noncoding RNAs (lncRNAs) could act as either oncogenes or tumor suppressor ... See full document

... Long noncoding RNA (lncRNA) is generally defined as a transcript larger than 200 nucleotides that lacks protein-coding functions. Recently, lncRNAs have been shown to have critical regulatory roles ... See full document

... biology. Recent transcriptome-wide surveys have uncovered evidence for promiscuous transcription across the entirety of the Kaposi’s sarcoma-associated herpesvirus (KSHV) genome and postulated the existence of ... See full document

... Abstract: Long thought to be “junk DNA”, in recent years it has become clear that a substan- tial fraction of intergenic genomic DNA is actually transcribed, forming long noncoding RNA ... See full document

... Noncoding RNA (ncRNA) will not usually directly code for protein and were considered as junk regions in the DNA with little to no functional ...are long noncoding RNA (lncRNA), which ... See full document

... Long noncoding RNA (lncRNA), broadly defined as noncoding RNA molecules longer than 200 nucleotides, has gained emerging attention in cancer biology due to their direct and indirect ... See full document

... time, some scholars extracted the exosomes from the serum of patients with CRC and detected the expression of CRNDE accurately. The results showed that CRNDE was highly expressed in CRC samples and could further ... See full document

... Long noncoding RNAs (lncRNAs) are operationally defined as RNA transcripts longer than 200 bp that do not appear to have coding potential ...[10]. Recent stud- ies indicated that lncRNAs have ... See full document

... its long length, lncRNA has the potential to develop multiple intramolecular RNA–RNA interactions conferring on them complex three-dimensional struc- ...of RNA, a feature of lncRNA is its ... See full document

... neovascularization and achieved certain efficacy. However, a considerable number of patients do not respond to the anti-VEGFs; moreover, local and systemic adverse events, including subretinal fibrosis, endophthalmitis, ... See full document

... member 5 (ZIC5) axis. 141 Similarly, SNHG6 overexpres- sion was associated with shorter DFS in the Cancer Genome Atlas (TCGA) and Taylor datasets, with bioinfor- matics analysis revealing SNHG6 is associated with ... See full document

... and had an unfavorable prognosis in patients with lung adenocarcinoma [54]. Gu et al. found that CCNB1 over- expression is closely related to poor survival in patients with HCC [55]. Knockdown of CCNB1 by RNA ... See full document

... Total RNA was extracted using TRIzol Reagent (Thermo Fisher Scientific, San Jose, CA, USA) according to the manufacturer’s ...protocol. RNA quantity was measured by the Nano Drop ND-2000 spectropho- tometer ... See full document

... We found that subjects with the minor alleles of rs4759314 and rs200349340 had significantly higher HOTAIR RNA levels (mean ± SD) than those with the major alleles in PC tissues (Fig. 2a, b, P < 0.01). Then ... See full document