[PDF] Top 20 Long noncoding RNAs and neuroblastoma

... CAI2 (CDKN2A/ARF Intron 2 lncRNA) is another neuroblastoma associated lncRNA located at the chromosomal locus 9p21, which harbors the well-known tumor suppressor genes CDKN2A and ARF [57]. CAI2 is a single exon ... See full document

... VHL-mutant RCC cell yet promoting the growth of VHL-normal RCC cell [57]. Decreases of lncRNAs such as NBAT-1 (neuroblastoma associated transcript-1) [58] and CASC2 [59] (cancer suscepti- bility candidate 2) are ... See full document

... RNA-seq experiments sequence millions to billions of short RNA fragments in a single experiment, by which it measures the expression levels of the whole transcriptome, including noncoding RNAs, without ... See full document

... Hox genes encode TFs that orchestrate the embryo body plan and contribute to several adult cell fate specification processes (Barber and Rastegar, 2010). In addition to containing protein-coding and miRNA genes, these ... See full document

... (miRNAs), long ncRNAs (LncRNAs) and the newly defined circular RNAs (circRNAs) in terms of length and ...Indeed, RNAs play fundamental roles in ...of RNAs, are critical [13, ...~21-nucleotide- ... See full document

... Long noncoding RNA (lncRNA) is a leader of the degree of more than 200 nucleotides, almost do not have the function of protein coding endogenous RNA ... See full document

... society. Long noncoding RNAs (lncRNAs) comprise a subgroup of noncoding RNAs (ncRNAs) longer than 200 nucleotides (nt), accounting for the largest proportion of the mammalian ... See full document

... protein-coding RNAs are present in the National Center for Biotechnology Information Reference Sequence data- base, we concentrated on coexpression with a high rate of protein-coding RNAs in the carcinoma ... See full document

... Noncoding RNAs (ncRNAs) are a superclass of endogenous, non-protein-coding RNA transcripts, many of which have essential functions in various cellular ...are long ncRNAs ... See full document

... Microarray of lncRNAs was performed by Beijing CapitalBio Technology Co., Ltd (Beijing, People’s Republic of China). lncRNAs from all canonical databases, NCBI Refseq, UCSC Known Gene, NRED, and RNAdb, were covered with ... See full document

... (or noncoding RNA) is mostly obscure, despite a larger number of noncoding genes than protein-coding ...for noncoding RNAs also span diverse cellular process- es, resulting in an array of ... See full document

... MD1: long intergenic noncoding RNA-muscle differentiation 1; lincRNA: long intergenic noncoding RNA; lncRNA: long noncoding RNA; Malat1: metastasis associated lung adenocarcinoma ... See full document

... LncRNAs exert important roles in myeloid differ- entiation and can respond to differentiation induc- tion therapy. At present, two lncRNAs, HOTAIRM1 and NEAT1 are known to regulate the differentiation of AML cells. ... See full document

... The recent identification of the genome-wide human lncRNA loci by the ENCODE project is undoubtedly a milestone toward the long-term goal of understanding the functional significance of lncRNAs in many biological ... See full document

... Abstract: Over the last two decades, genome-wide studies have revealed that only a small fraction of the human genome encodes proteins; long noncoding RNAs (lncRNAs) account for 98% of the total ... See full document

... Abstract: Noncoding RNAs (ncRNAs) can be divided into microRNAs (miRNAs), long noncod- ing RNAs (lncRNAs), circular RNAs (circRNAs), pRNAs, and ... See full document

... small RNAs [27-29]; some lncRNAs are transcribed from the intronic regions of human genome, processed at the consensus sequences close to 5’ splice site and branchpoint, and persist as circular intronic ... See full document

... Several studies have also demonstrated the prognostic signi fi cance of single lncRNAs in DLBCL. The lncRNA HOX transcript antisense RNA (HOTAIR) has been widely con fi rmed as a crucial regulator in human cancers. 33 ... See full document

... Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely pre- valent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of ... See full document

... Long noncoding RNAs (lncRNAs) are operationally defined as RNA transcripts longer than 200 bp that do not appear to have coding potential [10]. Recent stud- ies indicated that lncRNAs have become new ... See full document