[PDF] Top 20 V3 loop of the human immunodeficiency virus type 1 Env protein: interpreting sequence variability.
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V3 loop of the human immunodeficiency virus type 1 Env protein: interpreting sequence variability.
... Four features of the sequence heterogeneity in V3 were observed: i approximately 70%o of all nonconservative basic substitutions occur at four positions in V3, and V3 sequences with a ba[r] ... See full document
12
A naturally occurring single basic amino acid substitution in the V3 region of the human immunodeficiency virus type 1 env protein alters the cellular host range and antigenic structure of the virus.
... 68, 1994 BASIC AMINO ACID SUBSTITUTION IN V3 REGION OF HIV-1 DISCUSSION This and preceding papers clearly show that strains with a particular basic amino acid substitution at position 32[r] ... See full document
8
Subtype-Specific Conformational Differences within the V3 Region of Subtype B and Subtype C Human Immunodeficiency Virus Type 1 Env Proteins
... The V3 region of the human immunodeficiency virus type 1 gp120 Env protein is a key domain in Env due to its role in interacting with the coreceptors CCR5 ... See full document
14
Neutralizing antibodies against the V3 loop of human immunodeficiency virus type 1 gp120 block the CD4-dependent and -independent binding of virus to cells.
... anti-V3 loop antibodies completely inhibit the interaction of virus-associated gp120 with CD4 1 cells, without an apparent effect on the CD4 binding domain in gp120, suggest a direct or an ... See full document
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Variability in the Human Immunodeficiency Virus Type 1 gp120 Env Protein Linked to Phenotype-Associated Changes in the V3 Loop
... in V3 cannot be explained by phylogenetic relationships among se- ...V1V3-set 1 and V3C4-set 1, neighbor- joining trees were constructed from nucleotide sequence align- ...same V3 ... See full document
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Human immunodeficiency virus type 1 tropism for T-lymphoid cell lines: role of the V3 loop and C4 envelope determinants.
... of Env including the V3, V4, and V5 loops as well as the constant domains C3 and C4 lying between these variable ...loops. Sequence alignment of YU-2 and HXB2 sequences within the C4/V5 region ... See full document
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Relationship between the V3 loop and the phenotypes of human immunodeficiency virus type 1 (HIV-1) isolates from children perinatally infected with HIV-1.
... macrophagetropic type. An examination of the V3 sequences of intrapatient major variants and the biological phenotypes of our patient isolates disclosed that a negatively charged amino acid at position 25 ... See full document
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Effects of Partial Deletions within the Human Immunodeficiency Virus Type 1 V3 Loop on Coreceptor Tropism and Sensitivity to Entry Inhibitors
... vaccinia virus strain VTF1.1 expressing T7 polymerase (1) at a multiplicity of infection of 10 for 1 h at 37°C and then transfected for 4 h by the standard calcium phosphate method with 2 g of the ... See full document
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Semen-Specific Genetic Characteristics of Human Immunodeficiency Virus Type 1 env
... within env that were under positive selection in both compartments, focusing on individuals with compartmentalized ...signature. Sequence data from hosts A to G (including only data from the initial ... See full document
9
The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region.
... 1265 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The study of expression of several human immunodeficiency virus type 1 proviral mutants in human cells in the prese[r] ... See full document
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Sensitivity to a Nonpeptidic Compound (RPR103611) Blocking Human Immunodeficiency Virus Type 1 Env-Mediated Fusion Depends on Sequence and Accessibility of the gp41 Loop Region
... The human immunodeficiency virus type 1 (HIV-1) and HIV-2 envelope glycoproteins (Env) consist of noncovalent complexes of surface (gp120) and transmembrane (gp41) sub- ... See full document
9
Fold Recognition of the Human Immunodeficiency Virus Type 1 V3 Loop and Flexibility of Its Crown Structure During the Course of Adaptation to a Host
... the V3 loop has ...of protein may be simpler than previ- ously thought (B aker ...of protein-folding reactions and second, that nonnative interac- tion plays a relatively minor ... See full document
12
Chimeras from a human rhinovirus 14-human immunodeficiency virus type 1 (HIV-1) V3 loop seroprevalence library induce neutralizing responses against HIV-1.
... HRV14–HIV-1 V3 loop sero- prevalence ...many V3 loop sequences in a vast array of ...HRV14, loop 2 of the VP2 ...(Table 1). The central element of the V3 ... See full document
6
Use of random systematic mutagenesis to generate viable human rhinovirus 14 chimeras displaying human immunodeficiency virus type 1 V3 loop sequences.
... Sequences of 25 HRV14:HIV-1 chimeric viruses Virus Sequence HIV-1 V3 loop sequences' XXIGPGRAXXb A:1-1 A:2-1 A:3-1 A:4-1 A:5-1 A:6-1 A:7-1 A:8-1 A:9-1 A:10-1 PIGPGRA-EDIN.CON.V91 NIGPGRA[r] ... See full document
5
Sequential Turnover of Human Immunodeficiency Virus Type 1 env throughout the Course of Infection
... toward V3 rather than V1-V2 (7). Sequence changes observed in V1-V2 and V3 to V5, including insertions, deletions, and point mutations, have been linked to escape from neutralizing ...in env ... See full document
9
Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120
... 36-amino-acid sequence within HR2 and potently inhibits entry of HIV-1 into host cells most likely by interfering with the transition of gp41 into its fusion-active state (17, 26, ...target sequence ... See full document
10
The Crown and Stem of the V3 Loop Play Distinct Roles in Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Interactions with the CCR5 Coreceptor
... gp120 V3 loop is a major determinant of HIV-1 tropism and core- ceptor usage (for a review see reference ...The V3 loop is composed of approximately 35 residues and has a global pos- ... See full document
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Vaccine-Elicited V3 Loop-Specific Antibodies in Rhesus Monkeys and Control of a Simian-Human Immunodeficiency Virus Expressing a Primary Patient Human Immunodeficiency Virus Type 1 Isolate Envelope
... strain-specific virus-neutral- izing activity in the serum of human immunodeficiency virus type 1 (HIV-1)-infected individuals is mediated at least in part by antibodies ... See full document
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Patterns of Changes in Human Immunodeficiency Virus Type 1 V3 Sequence Populations Late in Infection
... for V3 in subjects who were treated with and developed resistance to ritonavir ...in V3 to V5 during the development of resistance to ritonavir or nelfinavir, although the changes were usually transient ... See full document
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Adaptive Mutations in a Human Immunodeficiency Virus Type 1 Envelope Protein with a Truncated V3 Loop Restore Function by Improving Interactions with CD4
... TA1 Env could en- hance function via several ...making Env more susceptible to the conformational changes that are in- duced by CCR5 ...unadapted V3(9,9) Env? Due to the poor function ... See full document
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