[PDF] Top 20 Lysophosphatidic acid signalling in development

... LPA signalling caused by ATX removal produces severe defects that are partially recapitulated by the deletion of individual ...LPA signalling during embryo development and paved the way for further ... See full document

... Autotaxin-Lysophosphatidic acid (ATX-LPA) axis in fibrotic lung ...phosphatidic acid (PA) by its deacylation, catalysed by phospholipase A (PLA)-type ...downstream signalling pathways activated ... See full document

... key signalling molecule is apparent due to its widespread occurrence in biological fluids and in majority of the tissues in the ...investigated signalling bias for the LPA ... See full document

... the development and progression of fibrosis, and on the mediators driving these ...processes. Lysophosphatidic acid (LPA), a biologically active lysophospholipid, is one such ...the ... See full document

... LPA evokes hormone­ and growth factor­like responses in almost all type of cells. LPA stimulates 3H­ thymine base insertion and activation of inositol phosphate, intracellular calcium and protein kinase C [13]. LPA ... See full document

... LPA-mediated signaling has been implicated in a wide range of cell behavior, including proliferation, survival, motility, cell shape and differentiation (Anliker and Chun, 2004; Fukushima et al., 2002; Tigyi, 2001; Ye et ... See full document

... fibrosis. Development of ATX inhibitors for clinical use has also received significant inter- est, and these compounds are being evaluated in preclinical stud- ies ...which development of BO is highly pen- ... See full document

... We have previously published the expression profile of enpp2a and enpp2b genes encoding for Xenopus laevis autotaxin pro- teins, the major lysoPLD enzyme producing extracellular LPA (Massé et al. 2010). Surprisingly, no ... See full document

... The potent efficacy of the anti-LPA mAb in mitigating trauma in the murine CCI model, together with the fact that LPA levels were also dysregulated in the mouse CSF following TBI, indicate that the findings from this ... See full document

... The exact role played over-expression of LPA2 in breast carcinogenesis is not yet clear. However, in ovarian cancer cells the proliferative responses to LPA of ovarian cancer cells with high levels of LPA1 receptor were ... See full document

... A subgroup analysis was performed to identify factors in- fluencing our study results. The potential factors tested were ethnicity, country and experimental method. Based on the limitations of the data available to us ... See full document

... as lysophosphatidic acid acyltransferase 2) (AGPAT2) occurs in plants, bacteria, yeast and animal cells ...and development of adipocytes, which are the body’s fat storing ...convert ... See full document

... Migration is a phenomenon that is mainly present dur- ing development [89]. In the adult CNS, the only cells thought to maintain the capacity for motility are stem cells or precursor cells in the subependymal ... See full document

... including lysophosphatidic acid receptor 1 (LPAR1), was significantly increased in the A-H/S-H ...for lysophosphatidic acid (LPA) and belongs to the G protein-coupled receptor (GPCR) ... See full document

... Ectopic endometrial tissue is involved in the patho- genesis of adenomyosis [21]. It has been reported that apoptosis is reduced in the ectopic endometrium compared with the eutopic endometrium in adeno- myosis [22]. It ... See full document

... of signalling molecules and expression patterns of RA synthesizing and metabolising enzymes are ...FGF signalling – eventually superseding RA – regulating it ... See full document

... In addition, in this study it was demonstrated that LPA stimulated granulosa and theca cell to produce 17-β- estradiol (functional marker) in mouse ovarian tissues that may promotes ovarian follicular development. ... See full document

... FGF signalling we decided to analyse ear- lier stages, focusing primarily on development of the opercle ...FGF signalling and a hs:fgf3 line to activate FGF ...FGF signalling throughout the ... See full document

... tional signalling, resulting in neurite outgrowth of the Contactin- expressing cell and a PTP-dependent, as yet to be identified, effect in the RPTPzeta/beta expressing ... See full document

... To help narrow the range of molecular weights for candidate molecules, we dialysed the bovine serum using a membrane that allowed diffusion of molecules with molecular weights of less than 6000—8000. Dialysing the serum ... See full document