[PDF] Top 20 Maternal Effect for DNA Mismatch Repair in the Mouse
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Maternal Effect for DNA Mismatch Repair in the Mouse
... lyzed. DNA isolated from the tail of each offspring was Figure 2b, lane 5; Table 1), both altered and normal- analyzed with a panel of microsatellite markers known sized DBA/2J alleles were transmitted to the F 2 ... See full document
7
DNA mismatch repair gene MSH6 implicated in determining age at natural menopause
... which DNA repair influences timing of menopause is yet to be determined, but it is conceivable that damage to DNA of meiotic cells, if not repaired effectively, would result in the activation of ... See full document
8
DNA methylation reprogramming and DNA repair in the mouse zygote
... the DNA methylation states of preimplantation embryos have been reported in various mammalian species as a conse- quence of manipulations such as ICSI, SCNT, cryopreservation of embryos and gametes or even only ... See full document
10
The relationship between the PD-1/PD-L1 pathway and DNA mismatch repair in cervical cancer and its clinical significance
... deficient DNA mismatch repair (dMMR) is capable of improving antitumor effects of the PD-1/PD-L1 pathway, suggesting that dMMR may act as a prognostic indicator of PD-1/PD-L1 antibody ... See full document
9
Role of DNA Mismatch Repair and Double-Strand Break Repair in Genome Stability and Antifungal Drug Resistance in Candida albicans
... morphology, DNA damage sensitivity, and antifun- gal drug sensitivity phenotypes associated with the loss of ...in DNA repair mutant strains might provide insight into the mechanisms of isochromosome ... See full document
12
Studies on protein:protein interactions in mammalian DNA base-excision repair
... in DNA editing during ...gapped DNA (Chou and Cheng, ...a mismatch directly, whereas DNase III would have to rely on the pausing of DNA ligase III to achieve this discrimination (Bhagwat et a ... See full document
210
Mismatch Repair Mutants in Yeast Are Not Defective in Transcription-Coupled DNA Repair of UV-Induced DNA Damage
... coli mis- match repair mutants, we found that mutations in yeast mismatch repair genes had no discernable effect upon either transcription-coupled repair or global nucleotide [r] ... See full document
9
The Role of DNA Mismatch Repair and Recombination in the Processing of DNA Alkylating Damage in Living Yeast Cells
... of DNA damaging agents by exerting a futile repair pathway in which O 6 -meG con- tinually produces a template for MMR system [12] and leads to repeated cycles of repair resulting in the forma- tion ... See full document
11
Thyroid cancer in a patient with a germline MSH2 mutation. Case report and review of the Lynch syndrome expanding tumour spectrum
... approach, the tumour spectrum can be broadened through analysis of tumours occurring in MMR gene mutation carriers. Again, patients with atypical Lynch syndrome tumours as listed in Table 2 more often have been reported ... See full document
7
Characterization of the Repeat-Tract Instability and Mutator Phenotypes Conferred by a Tn3 Insertion in RFC1, the Large Subunit of the Yeast Clamp Loader
... between mismatch repair and meric interactions and is also defective in in vitro DNA RFC functions was not observed in the repeat-tract insta- replication reactions (Table 3; Ayyagari et ...the ... See full document
11
Saturation of DNA Mismatch Repair and Error Catastrophe by a Base Analogue in Escherichia coli
... ability Effect of repair deficiencies other than DNA mis- was more severe in the mismatch-repair-defective mutS match repair: To check if dP mutagenesis might involve strain than ... See full document
10
Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans
... of DNA mutations at high ...match repair pathway, and complementation confirmed that these mutations are re- sponsible for the mutator ...eight mismatch repair pathway genes in ...no ... See full document
18
Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells
... DNA mismatch repair (MMR) enzymes act as proofreading complexes that maintains genomic integrity and MMR-deficient cells show an increased mutation ...the effect of PMS2 on growth properties ... See full document
11
PMS2 gene mutation results in DNA mismatch repair system failure in a case of adult granulosa cell tumor
... The DNA sequences of four genes, MSH2, MLH1, MSH6, and PMS2, in the DNA mismatch repair system were determined via direct ...the DNA samples from paraffin-embedded tumor specimens ... See full document
5
A gene expression assay for simultaneous measurement of microsatellite instability and anti-tumor immune activity
... DNA mismatch repair deficiency (MMRd) has been observed in most cancer types in The Cancer Genome Atlas (TCGA), and occurs in more than 5% of adrenal, rectal, colon, stomach, and endometrial tumors ... See full document
12
Requirement of Mismatch Repair Genes MSH2 and MSH3 in the RAD1-RAD10 Pathway of Mitotic Recombination in Saccharomyces cerevisiae
... The MSH2 and MSH3 genes participate in DNA mismatch repair; null mutations in these genes result in elevated rates of spontaneous mutations and in an increase in the [r] ... See full document
10
Genetic variants within the hTERT gene and the risk of colorectal cancer in Lynch syndrome
... Our study has the largest number of MMR gene mutation carriers assessed to date for genetic modifiers of the hTERT gene on CRC risk. A possible limitation of our study is its generalizability only to MMR gene mutation ... See full document
7
Characterisation of unusual DNA glycosylases from Trichomonas vaginalis
... This DNA repair mechanism requires the recognition of DNA ends by the Ku heterodimer, made up of Ku70 and Ku80 proteins, which binds to the DSB (Davis and Chen, ...the DNA ends, which ... See full document
174
Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime Avibactam Resistance in Pseudomonas aeruginosa Acute Infection
... high-fidelity DNA replication and the reduction of spontaneous mutation rates are beneficial to ...replicative DNA polymerases and an array of DNA repair proteins broadly organized into ... See full document
15
The Effect of Mismatch Repair and Heteroduplex Formation on Sexual Isolation in Bacillus
... We have compared the relationship between sexual isola- tion and sequence divergence in two isogenic recipient strains, one that is wild type (1A96) and one that is defi- cient for the g[r] ... See full document
6
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