[PDF] Top 20 CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4+ T-Cell Depletion in Human Lymphoid Tissue Ex Vivo
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CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4+ T-Cell Depletion in Human Lymphoid Tissue Ex Vivo
... NA7 nef alleles in five in vitro assays: (i) down-modulation of CD4; (ii) MHC-I down-regulation; (iii) enhancement of virion infectivity; (iv) stimulation of viral ... See full document
5
Mechanisms of HIV-1-mediated CD4+ T cell depletion in lymphoid tissue
... the human immune system. Through a detailed study of viral pathogenesis, I believe that mechanisms of pathogen/host interaction can be ...both viral- and immune-mediated factors that contribute to ... See full document
153
Presence of Host ICAM-1 in Laboratory and Clinical Strains of Human Immunodeficiency Virus Type 1 Increases Virus Infectivity and CD4+-T-Cell Depletion in Human Lymphoid Tissue, a Major Site of Replication In Vivo
... the ex vivo culture of human tonsillar tissue. This cell culture model has been used to study various aspects of HIV-1 pathogenesis (23, 24, 26, 29, ...the ex vivo ... See full document
11
Nef Enhances Human Immunodeficiency Virus Replication and Responsiveness to Interleukin-2 in Human Lymphoid Tissue Ex Vivo
... parental virus stock and one stock of Dnef mutant virus were obtained by transfection of COS-7 cells with pNL43 and pNL43Dnef (kindly provided by ...DnefNL4-3 viral stocks was measured by terminal ... See full document
7
Differential Pathogenesis of Primary CCR5-Using Human Immunodeficiency Virus Type 1 Isolates in Ex Vivo Human Lymphoid Tissue
... studied viral isolates, all of which were of the R5 phenotype. Whatever the viral factors that determine differen- tial pathogenesis of these R5 isolates in tissues are, we provide here the first published ... See full document
10
CpG Oligodeoxynucleotides Block Human Immunodeficiency Virus Type 1 Replication in Human Lymphoid Tissue Infected Ex Vivo
... for human immunodefi- ciency virus (HIV) ...in human lymphocyte cultures and found that phosphorothioate-modified ODN CpG2006 (type B ODNs) inhibited HIV replication nearly completely ... See full document
11
Association of Nef with p21-Activated Kinase 2 Is Dispensable for Efficient Human Immunodeficiency Virus Type 1 Replication and Cytopathicity in Ex Vivo-Infected Human Lymphoid Tissue
... on Nef-mediated receptor mod- ...on Nef function in virally infected primary human cells, we cloned all nef alleles into a replication-competent HIV-1 NL4-3-based proviral vector ... See full document
10
Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis
... The nef gene products encoded by human immunodeficiency virus type 1 (HIV-1) and simian immunodefi- ciency virus type 1 (SIV-1) increase ... See full document
10
Interactions between Human Immunodeficiency Virus Type 1 and Vaccinia Virus in Human Lymphoid Tissue Ex Vivo
... that ex vivo lymphoid tissues support productive infection by NYBCH, the VACV strain of ...both T and non-T lymphocytes, the latter more effi- ...and T cells among peripheral ... See full document
7
CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.
... three viral genes achieve what we estimate is virtually complete depletion of cell surface ...on CD4 regulation implies that the down-modulation of CD4 should be critical ... See full document
10
Human Immunodeficiency Virus Type 1 Induces Apoptosis in CD4+ but Not in CD8+ T Cells in Ex Vivo-Infected Human Lymphoid Tissue
... Human lymphoid tissue ex vivo supports replication of dif- ferent HIV variants and does not require exogenous stimula- tion (20, ...that tissue blocks do not require ... See full document
8
Vpr and Vpu Are Important for Efficient Human Immunodeficiency Virus Type 1 Replication and CD4+ T-Cell Depletion in Human Lymphoid Tissue Ex Vivo
... Human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) have several genes that are not absolutely required for viral spread in ... See full document
5
Determinants in HIV 1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo
... of cell death in infected and bystander cells detected closely matched that of apoptotic cells detected by others ...of Nef. Collectively, our results therefore suggest that the Nef-mediated increase ... See full document
14
Viral Interactions in Human Lymphoid Tissue: Human Herpesvirus 7 Suppresses the Replication of CCR5-Tropic Human Immunodeficiency Virus Type 1 via CD4 Modulation
... and ex vivo-infected blocks of human lymphoid tissue 12 days ...to cell surface staining, counting beads (Caltag) were added to each tube to quantify cell ...total ... See full document
10
Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: requirement of a site in the nef gene for HIV-1 replication in activated CD4+ T cells in vitro and in vivo.
... HIV-1 replication is highly dependent on cell prolif- eration (63), we counted the number of activated CD4 1 T cells infected with each mutant virus or mock virus ... See full document
11
Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes.
... of CD4 from the recycling to the degradative pathway (19, 24, ...and Nef induce CD4 endocytosis, it is likely that they act according to different ...that CD4 mutants that do not, or only ... See full document
10
Chronic CD4+ T-Cell Activation and Depletion in Human Immunodeficiency Virus Type 1 Infection: Type I Interferon-Mediated Disruption of T-Cell Dynamics
... activated CD4 ⫹ T cells of HIV ⫹ ...Affymetrix Human Genome GeneChip array U133Plus ...the 1-kb sequence upstream of the start transcription site associated with that RefSeq ID, using ... See full document
14
Strong Ability of Nef-Specific CD4+ Cytotoxic T Cells To Suppress Human Immunodeficiency Virus Type 1 (HIV-1) Replication in HIV-1-Infected CD4+ T Cells and Macrophages
... NL-432 virus particles induced more than 90% of the CD4 ⫹ T cells from the Nef-specific clones to produce IFN- ␥ , whereas those cells pulsed with NL-Xh (Nef-depleted) virus ... See full document
10
Lentiviral Vectors Interfering with Virus-Induced CD4 Down-Modulation Potently Block Human Immunodeficiency Virus Type 1 Replication in Primary Lymphocytes
... simian immunodeficiency virus (SIV) Nef have highlighted the importance of this protein in viral pathogene- ...in nef replicate poorly in rhesus macaques and usually do not cause AIDS ... See full document
10
Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity.
... No depletion of CD4+ human thymocytes was observed in implants infected with either HIV-lJRCSF or its nef mutant at 3 or 6 weeks postinfection compared with controls consisting of mock-i[r] ... See full document
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