[PDF] Top 20 Mouse T cells restrict replication of human immunodeficiency virus at the level of integration
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Mouse T cells restrict replication of human immunodeficiency virus at the level of integration
... Both T-cell lines and primary T-cells from mice harbor a severe post-entry defect that is independent of potential species-specTR ...into mouse T-cells, and abundant levels of ... See full document
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Murine T Cells Potently Restrict Human Immunodeficiency Virus Infection
... murine T cells compared to NIH 3T3 ...higher virus penetration rate measured for murine T cells than for fibroblasts ...murine T cells at the level of reverse ... See full document
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RevM10-expressing T cells derived in vivo from transduced human hematopoietic stem-progenitor cells inhibit human immunodeficiency virus replication.
... as cells differentiated, transgenes may have been partially or entirely silenced by mechanisms governing expres- sion, such as changes in chromatin structure, DNA methyl- ation, or cis-acting silencing elements ... See full document
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Multiple Blocks to Human Immunodeficiency Virus Type 1 Replication in Rodent Cells
... of human gene products that are required for early steps in the human immuno- deficiency virus type 1 (HIV-1) life cycle has raised the possibility that rodents might be engineered to support HIV-1 ... See full document
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Addition of Deoxynucleosides Enhances Human Immunodeficiency Virus Type 1 Integration and 2LTR Formation in Resting CD4+ T Cells
... resulting cells were 97% rCD4 cells. Finally, aCD4 cells were prepared by stimulating ppCD4 cells with anti-CD3/CD28 beads for 3 ...of cells were in the left lower ...of cells ... See full document
5
Immediate Activation Fails To Rescue Efficient Human Immunodeficiency Virus Replication in Quiescent CD4+ T Cells
... activated T cells, quiescent CD4 ⴙ T cells have shown resistance to human immunodeficiency virus (HIV) infection due to a block in the early events of the viral life ...ⴙ ... See full document
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Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes
... CD8 T cells is important for immunogen design, and yet most current assays do not measure the ability of responses to neutralize infectious ...that human immunode- ficiency virus ... See full document
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Emergence of Polyfunctional CD8+ T Cells after Prolonged Suppression of Human Immunodeficiency Virus Replication by Antiretroviral Therapy
... Progressive human immunodeficiency virus type 1 (HIV-1) infection is often associated with high plasma virus load (pVL) and impaired CD8 ⴙ T-cell function; in contrast, CD8 ⴙ T ... See full document
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Human Endothelial Cells Enhance Human Immunodeficiency Virus Type 1 Replication in CD4+ T Cells in a Nef-Dependent Manner In Vitro and In Vivo
... and T-cell cocultures greatly enhanced Nef ⫹ production without greatly changing IL-2 elaboration, and the addition of BLCs to EC and T-cell cocultures greatly enhanced HIV-1 production in naı¨ve T ... See full document
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Efficient Human Immunodeficiency Virus Replication Requires a Fine-Tuned Level of Transcription
... lowest level of gene expression in the context of the whole viral genome, we set out to measure directly the amount of HIV RNA produced by the LTR in infected T ...SupT1 cells with viruses containing ... See full document
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Susceptibility of Rat-Derived Cells to Replication by Human Immunodeficiency Virus Type 1
... proviral integration appeared to be intact in many rat-derived ...rat-derived cells exhibited robust HIV-1 LTR activity as determined by HIV-1 NL4-3 pseudotype reporter virus infections, HIV-1 ... See full document
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Human immunodeficiency virus infection of monoblastoid cells: cellular differentiation determines the pattern of virus replication.
... Expression of this gene changes normally in response to the state of cellular differentiation; in infected cells the level of c-myc expression was correlated to the levels of viral RNA..[r] ... See full document
7
Regulation of Human Immunodeficiency Virus Type 1 Replication in Human T Lymphocytes by Nitric Oxide
... both T cells and mac- rophages, although the enhancing effect of NO was observed with X4 but not with R5 ...in T-cell lines, leads us to believe that the effect of NO observed in PBMC is at the ... See full document
9
High-Level Replication of Human Immunodeficiency Virus in Thymocytes Requires NF-κB Activation through Interaction with Thymic Epithelial Cells
... We then showed that NF-kB activity observed in freshly isolated thymocytes was the result of specific signals delivered within the microenvironment. This activity, which is mainly due to p50-p65 complexes, decreased when ... See full document
10
CD4-Negative Cells Bind Human Immunodeficiency Virus Type 1 and Efficiently Transfer Virus to T Cells
... Raji cells do not selectively bind infectious ...enhanced virus infection in the coculture system is Raji cell binding of only infection-competent virus ...Raji cells bind only infectious ... See full document
8
Productive Replication of Human Adenoviruses in Mouse Epidermal Cells
... rodent cells were able to express the early gene E1A proteins after ...between cells that showed no evidence for virus replication and those that showed either a weak CPE and low-level ... See full document
5
Human immunodeficiency virus type 1 DNA synthesis, integration, and efficient viral replication in growth-arrested T cells.
... Likewise, as shown with irradiated blood monocytes, cell division per se is not required for productive HIV-1 infection and viral DNA integration (65), although cell acti- vation and/or [r] ... See full document
9
Human Immunodeficiency Virus Integration Efficiency and Site Selection in Quiescent CD4+ T Cells
... of integration sites was made possible by the use of an inverse PCR ...quiescent cells and 318 in stimulated cells. In both cell types, integration sites were found mostly within ... See full document
12
Inhibition of human immunodeficiency virus type 1 replication in human T cells stably expressing antisense RNA.
... In cell lines with antisense RNA expression detectable by Northern (RNA) hybridization, human immunodeficiency virus type 1 replication was inhibited to 88% 10 days postinfection and thi[r] ... See full document
5
Replication of the human immunodeficiency virus 1 and impaired differentiation of T cells after in vitro infection of bone marrow immature T cells
... mononuclear cells (BMMC) depleted of mature T cells was ...marrow cells were shown to differentiate during the culture into CD3+, CD4+, CD8+, and CD1+ cells, whereas noninfected BMMC ... See full document
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