[PDF] Top 20 Multiple binding sites for polyomavirus large T antigen within regulatory sequences of polyomavirus DNA.
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Multiple binding sites for polyomavirus large T antigen within regulatory sequences of polyomavirus DNA.
... 3 0022-538X1841120750-11$02.00/0 Copyright C 1984, American Society for Microbiology Multiple Binding Sites for Polyomavirus Large T Antigen Within Regulatory Sequences of Polyomavirus D[r] ... See full document
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Sequences flanking the pentanucleotide T-antigen binding sites in the polyomavirus core origin help determine selectivity of DNA replication.
... mPy T antigen together with a murine FM3A cell extract capable of replicating mPy DNA can replicate an LPV origin in ...the DNA sequences that restrict replication of the LPV origin, we ... See full document
9
Polyomavirus Large T Antigen Binds the Transcriptional Coactivator Protein p300
... p300 binding, and the T antigens from SV40 and polyomavirus, in which ill-defined domains within the C-terminal parts of the proteins play a role in interactions with p300, points once more to ... See full document
6
Novel Regulatory Mechanisms by Which Large T Antigen Coordinates the Merkel Cell Polyomavirus Life Cycle
... Polyomavirus Large T antigen (LT) is a multifunctional protein which manipulates the host cell and regulates replication of the viral genome as well as transcription of both the early and late ... See full document
165
Polyomavirus Large T Antigen Binds Cooperatively to Its Multiple Binding Sites in the Viral Origin of DNA Replication
... stimulates binding of polyomavirus large T antigen to an origin DNA fragment at pH ...filter binding assay, but found no effect of ATP on binding at pH 7 or ...a ... See full document
11
Zinc-binding and protein-protein interactions mediated by the polyomavirus large T antigen zinc finger.
... pBR322 sequences, the Harvey sarcoma- virus long terminal repeat for transcription initiation, and an LT cDNA from pTR880 ...EcoRI sites (not in LT se- quences) of both pBLT and pLTR880 were deleted by ... See full document
8
The Retinoblastoma Protein Alters the Phosphorylation State of Polyomavirus Large T Antigen in Murine Cell Extracts and Inhibits Polyomavirus Origin DNA Replication
... to sites of viral replication in herpesvirus- infected ...SV40 T Ag, prevents assembly of T Ag hexamers at the core origin and also interferes with the interaction of T Ag with DNA ... See full document
10
Polyomavirus large T antigen binds independently to multiple, unique regions on the viral genome.
... To test the applicability of this method for measuring the binding of polyomavirus large T antigen to specific viral DNA fragments, we incubated increasing amounts of nuclear extract fro[r] ... See full document
11
Polyomavirus and simian virus 40 large T antigens bind to common DNA sequences.
... Initially, we measured the binding of polyomavirus large T antigen present in a nuclear extract from infected 3T6 cells to end-labeled DNA fragments obtained by Hinfl hydrolysis of pPH1-[r] ... See full document
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The DNA-binding properties of polyomavirus large T antigen are altered by ATP and other nucleotides.
... In the absence of ATP and with increasing quantities of Py TAg, sites A and B as well as site C, for which the data are not shown, on the early side of the origin palindrome, were protec[r] ... See full document
13
Activation of CREB/ATF Sites by Polyomavirus Large T Antigen
... of polyomavirus large T) (33), pCMV P43S LT (which contains a mutation in the HPD loop of the J domain) (67), pCMV NT (residues 1 to 259) (33), and pCMV-CT (residues 264 to 785) (27) have been ... See full document
11
Guanine nucleotide contacts within viral DNA sequences bound by polyomavirus large T antigen.
... 505 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Essential nucleotide contacts between the polyomavirus large T antigen and its multiple specific binding regions wit[r] ... See full document
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J Domain-Independent Regulation of the Rb Family by Polyomavirus Large T Antigen
... of polyomavirus large T antigen (LT) to promote cell cycling, to immortalize primary cells, and to block differentiation has been linked to its effects on tumor suppressors of the ... See full document
11
AP1 enhances polyomavirus DNA replication by promoting T-antigen-mediated unwinding of DNA.
... with T antigen. We searched for in- teractions between T antigen and Fos or Jun by incubating Fos and Jun (each immobilized on a membrane) with T antigen; after extensive ... See full document
5
Polyomavirus middle T-antigen NPTY mutants.
... 5770 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest A polyomavirus middle T-antigen MTAg mutant containing a substitution of Leu for Pro at amino acid 248 has previousl[r] ... See full document
7
Host range and cell cycle activation properties of polyomavirus large T-antigen mutants defective in pRB binding.
... The finding that pRB-binding polyomavirus mutants have a host range determined by expression of the targeted tumor suppressor gene in the host raises the possibility that a systematic st[r] ... See full document
8
Cyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen.
... Py T Ag by cyclin B-cdc2 affected its ability to mediate Py ori DNA replication in ...vitro. T Ags were preincubated with or without cdc2-cyclin B for 30 min on ice, prior to addition to replication ... See full document
7
In vitro mutagenesis of the putative membrane-binding domain of polyomavirus middle-T antigen.
... 82 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Polyomavirus middle-T antigen contains a contiguous sequence of 22 hydrophobic amino acids near the carboxyl terminus[r] ... See full document
8
Binding of Polyomavirus Small T Antigen to Protein Phosphatase 2A Is Required for Elimination of p27 and Support of S-Phase Induction in Concert with Large T Antigen
... the large and the small tumor antigens, and that of polyoma- virus (Py) encodes the large, the middle, and the small T antigens (LT, MT, and ST, ...the large T antigens of SV40 and Py ... See full document
8
Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain.
... tiny T antigen protein. Previous analyses of the expression of muPy T antigens in infected or transformed cells did not detect tiny T antigen, probably because the electro- phoretic ... See full document
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