[PDF] Top 20 Mutational Analysis of Influenza A Virus Nucleoprotein: Identification of Mutations That Affect RNA Replication
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Mutational Analysis of Influenza A Virus Nucleoprotein: Identification of Mutations That Affect RNA Replication
... full-length virus-specific transcripts requires fully encapsidated templates (10, ...by analysis of a virus with a Ts defect in the NP gene which can be extragenically suppressed by a defect in the ... See full document
9
Identification of Amino Acid Residues of Influenza Virus Nucleoprotein Essential for RNA Binding
... binding RNA to the N-terminal one-third of the polypeptide ...to RNA with lower affinity than did the WT protein, indicating the necessity for other sequences for full binding activity ...with RNA ... See full document
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Mutational Analysis of Hepatitis C Virus Nonstructural Protein 5A: Potential Role of Differential Phosphorylation in RNA Replication and Identification of a Genetically Flexible Domain
... not affect RNA replication significantly (data not ...HCV RNA replication ...enhanced RNA replication (Fig. 1B). Interestingly, these mutations have so far not been ... See full document
8
Identification and Characterization of Three Novel Nuclear Export Signals in the Influenza A Virus Nucleoprotein
... in virus replication, our results supported that it might be involved in the viral protein expression at the posttranscription ...to influenza A virus mRNA nuclear export, the mechanism is not ... See full document
11
Sequence in the Influenza A Virus Nucleoprotein Required for Viral Polymerase Binding and RNA Synthesis
... viral RNA synthesis as determined in minigenome ...an influenza vi- rus mini-RNP (5) as a guide for our mutational analysis of NP to identify a sequence that is required for viral RNA ... See full document
6
Mutational Analysis of Conserved Amino Acids in the Influenza A Virus Nucleoprotein
... A virus NP has at least two NLS ...these mutations significantly re- duced viral transcription, consistent with a previous report that the bipartite NLS was essential for vRNA transcription ...viral-genome ... See full document
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Stabilization of Influenza Virus Replication Intermediates Is Dependent on the RNA-Binding but Not the Homo-Oligomerization Activity of the Viral Nucleoprotein
... homo-oligomerization mutations in NP on cRNA stabilization and ...the RNA polymerase, wild-type (wt), none ( ⫺ ), or mutant H1N1 NP, and an NA gene-specific vRNA (A) or cRNA (B) ...Viral RNA species ... See full document
7
Mutational Analysis of cis-Acting RNA Signals in Segment 7 of Influenza A Virus
... WT virus (plotted graphically in ...with mutations in conserved regions to cause a single round of infection were similar to the relative reductions in their plaque titers ...of virus particles ... See full document
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Mutational Analysis of the Rubella Virus Nonstructural Polyprotein and Its Cleavage Products in Virus Replication and RNA Synthesis
... directed mutations was generated by PCR ...introduced mutations are conservative alterations, such as C to S and G to A, and thus are unlikely to affect the overall structure of the protein or ... See full document
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Mutations in the N-Terminal Region of Influenza Virus PB2 Protein Affect Virus RNA Replication but Not Transcription
... and replication of influenza A virus genes is mediated by viral ribonucleoprotein complexes (vRNPs) that contain each of the eight negative-polarity, single-stranded RNA segments associated ... See full document
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Specific Nucleoprotein Residues Affect Influenza Virus Morphology
... raphy analysis revealed that M1 dimers stack on top of one an- other to create a ribbon-like structure through two separate points of interaction ...of influenza virus ...that mutations at ... See full document
8
Nuclear Factor 90 Negatively Regulates Influenza Virus Replication by Interacting with Viral Nucleoprotein
... H5N1 virus NP. Several cellular factors associated with the influenza virus replication complex have recently been identi- fied by using the yeast-two-hybrid system or Co-IP combined with ... See full document
12
Mutational Analysis of Bovine Viral Diarrhea Virus RNA-Dependent RNA Polymerase
... diarrhea virus (BVDV) nonstructural protein 5B (NS5B) produced in insect cells has been shown to possess an RNA-dependent RNA polymerase (RdRp) ...C virus (HCV) NS5B, we constructed a similar ... See full document
8
Influenza Virus Nucleoprotein Interacts with Influenza Virus Polymerase Proteins
... to replication mode in the infectious cycle remains ...product RNA be- come modified by the viral and cellular ...ing RNA synthesis from transcription to replication and in the synthesis of ... See full document
9
Replication Mode and Landscape Topology Differentially Affect RNA Virus Mutational Load and Robustness
... that mutations have two immediate ...of mutations generating stop codons, severely modifying ribosomal entry sites, or altering signals for replicase binding, it is assumed that mutations will not ... See full document
11
Packaging of the Influenza Virus Genome Is Governed by a Plastic Network of RNA- and Nucleoprotein-Mediated Interactions
... infectious virus particles ...multicycle replication kinetics in MDCK-II cell ...SC35M, replication of rS1mut and rS3mut was not affected ...This analysis revealed similar vRNA segment levels ... See full document
11
Mutational analysis of the hepatitis C virus RNA helicase.
... and RNA helicase activi- ...of RNA or DNA ...possessed RNA helicase activity that was one-fourth to one-fifth of that of the wild-type ...the mutational effects at the same site in eIF-4A and ... See full document
10
Structural Basis for RNA Binding and Homo-Oligomer Formation by Influenza B Virus Nucleoprotein
... negative-sense RNA viruses not only encapsidates RNA in different manners, they also adopt various strategies to form ...Lassa virus NP uses its N-ter- minal domain to interact with the C-terminal ... See full document
10
Mutations in the cytoplasmic tail of influenza A virus neuraminidase affect incorporation into virions.
... Transfectant virus was obtained with all cytoplasmic tail mutants generated by site-directed mutagenesis of the influenza A virus tail, except for the mutant resulting from substitution [r] ... See full document
6
Exosome-delivered and Y RNA-derived small RNA suppresses influenza virus replication
... IAV replication but instead inhibits viral replication implies that it may be involved in cellular antiviral ...inhibit virus replica- tion by stimulating interferon production [17, 32, ...IAV ... See full document
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