[PDF] Top 20 Original Article Inhibition of proliferation and migration of osteosarcoma cells U2OS by phenformin
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Original Article Inhibition of proliferation and migration of osteosarcoma cells U2OS by phenformin
... [6-8]. Active glycolysis is very common in can- cer cells, so enhanced glucose metabolism always become a target for cancer therapy [9-11]. Biguanides, a class of medication used to treat type II diabetes, exert ... See full document
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Original Article MicroRNA-608 inhibits the cell proliferation in osteosarcoma by macrophage migration inhibitory factor
... Cells were lysed with ice-cold lysis RIPA buffer (ProMab Biotechnology, NY, USA) in the pres- ence of Protease Inhibitor Cocktail (Pierce, Philadelphia, PA, USA). Protein concentration was quantified by the ... See full document
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Original Article MicroRNA-132 inhibits human osteosarcoma cell proliferation and migration by targeting SOX4
... The 3’-UTR sequence of SOX4, which was pre- dicted to interact with miR-132, or a mutant sequence with the predicted target sites, were synthesized and inserted into pMir-Report (Ambion, USA), yielding pMir-Report-SOX4. ... See full document
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Original Article miR-17-5p promotes proliferation and migration of CAL-27 human tongue squamous cell carcinoma cells involved in autophagy inhibition under hypoxia
... glioma cells decreases Beclin-1-mediated autophagy and radioresistance [22], supporting the present ...cancer cells acquire resistance to adverse environmental conditions and can- cer treatments [5, 10, 12, ... See full document
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Original Article IGF-1R inhibitor PQ401 inhibits osteosarcoma cell proliferation, migration and colony formation
... the U2OS cell line has the top level of IGF-1R expression in the available cell lines described in the human protein atlas but also verified that the IGF-1R expression was approximately 8 times higher than that of ... See full document
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Original Article MLLT3 promotes proliferation of osteosarcoma cells by regulating JNK signaling
... Abstract: Osteosarcoma was the most common malignant tumor derived from bone/soft tissues and afflicted main- ly the ...in osteosarcoma was not previously ...in osteosarcoma tissues and cell lines ... See full document
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Original Article MiRNA-15a inhibits proliferation, migration and invasion by targeting TNFAIP1 in human osteosarcoma cells
... using PCR from human cDNA using primers, and inserted into the pMIR-REPORT luciferase reporter vectors (Ambion, Austin, TX, USA) to get the constructs containing the wild-type TNFAIP1 3’-UTR (TNFAIP1-WT). TNFAIP1-Mut ... See full document
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Original Article Effect of FGFR2IIIc S252W overexpression upon osteosarcoma U2OS cell proliferation via activating ERK1/2 and JNK signaling pathways
... Ltd. U2OS cells were fed in a 6-well plate the day before transfected at 80% confluence in suspension ...to cells by Lipofectime 2000TM following the manufac- tures’ protocols of ... See full document
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Original Article The effect of miR27b on osteosarcoma cell proliferation and invasion
... of migration and in- vasion of MG-63 ...the migration and invasion of MG-63 ...growth, proliferation, and metastasis of neuro- blastoma via acting on the peroxisome prolifer- ator-activated receptors ... See full document
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Original Article Loss of SOX5 protein expression by RNAi in osteosarcoma cells suppresses cell proliferation and invasion
... and U2OS cells, which expressed high levels of SOX5 by siRNA ...and U2OS cells was evaluated at both mRNA and protein levels by real-time PCR and west- ern blot, respectively (Figure 2B and ... See full document
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Original Article Down-regulation of miR-451 promotes invasion and proliferation of human osteosarcoma U2OS cells via RAB14-mediated AMPK-Akt-mTOR signaling pathway
... in osteosarcoma cell line significantly inhibited cell prolifera- tion and invasion, and promoted cell adhere to matrix by down-regulating Ras-related protein 14 (RAB14) expres- ... See full document
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Original Article microRNA-486 suppressed proliferation, migration and invasion of osteosarcoma cells via directly targeting SIRT1
... Sirtuins are nicotinamide adenine dinucleotide (NAD)+-dependent protein deacetylase class III histone deacetylases [34]. The sirtuin family includes seven members, designated SIRT1 through SIRT7, which are characterized ... See full document
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Original Article ClC-3 chloride channel modulates the proliferation and migration of osteosarcoma cells via AKT/GSK3β signaling pathway
... excessive proliferation of cells is closely related to ...cell proliferation accompany with changes in cell volume and the activity of VRCC (volume regulated chloride channel, ...of cells ... See full document
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Original Article Apoptosis prediction via inhibition of AKT signaling pathway by neogrifolin
... Abstract: Neogrifolin, a natural biologically active substance isolated from the edible bodies of the mushroom Albatrellus confluens, has been shown to possess several pharmacological properties. No studies were investi- ... See full document
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Original Article Increased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcoma
... human osteosarcoma remains ...in osteosarcoma tissues and cell lines was detected by quantitative real-time ...of osteosarcoma patients was performed by the Kaplan-Meier and Cox proportional ... See full document
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Original Article Metformin induces apoptosis of osteosarcoma U2OS and 143B cells through the mitochondria-dependent pathway and potentiates the anti-neoplastic activity of cisplatin in vivo
... direct inhibition of Insulin growth factor (IGF)-mediated cellular ...in Osteosarcoma (OS) have not been fully ...The U2OS and 143B OS cells were treated with metformin, cisplatin or a ... See full document
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Krüppel-like factor 4 promotes human osteosarcoma growth and metastasis via regulating CRYAB expression
... MG63 cells with or without stably knockdown KLF4 were subjected to cDNA microarray analysis to identify the potential associated ...knockdown cells (data not ...SaOS2 cells (Figure ...SaOS2 ... See full document
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miRNA-30c can be used as a target in the diagnosis and treatment of osteosarcoma
... the osteosarcoma tissue than in normal bone tissue ...advanced osteosarcoma staging and low cellular ...(P,0.01). U2OS cell growth was significantly inhibited when transfected with miR-30c ...of ... See full document
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<em>MALAT1 </em>promotes proliferation, migration, and invasion of MG63 cells by upregulation of <em>TGIF2 </em>via negatively regulating <em>miR-129</em>
... qRT-PCR was conducted to determine MALAT1 expression in tissues and cells. The results showed significantly increased MALAT1 relative expression in osteosarcoma tumor tis- sues than that in adjacent tissues ... See full document
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<p>LncRNA TDRG1 Promotes Proliferation, Invasion and Epithelial-Mesenchymal Transformation of Osteosarcoma Through PI3K/AKT Signal Pathway</p>
... on osteosarcoma, but also had a close relationship with the clinical characteristics of osteosarcoma patients, such as pathological staging, tumor size, and ...in osteosarcoma cells to explore ... See full document
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