[PDF] Top 20 Palmitoylation and Polymerization of Hepatitis C Virus NS4B Protein
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Palmitoylation and Polymerization of Hepatitis C Virus NS4B Protein
... of NS4B palmitoylation and polymerization in the HCV replicon or the complete viral replication ...studying NS4B palmitoylation in cells containing an HCV rep- licon, the main problem ... See full document
11
Hyperphosphorylation of the Hepatitis C Virus NS5A Protein Requires an Active NS3 Protease, NS4A, NS4B, and NS5A Encoded on the Same Polyprotein
... and NS4B are required in cis for NS5A hyperphos- ...the protein was present as a non- processed fusion protein NS3/NS5A ...and NS4B in trans resulted in complete cleavage of the fusion ... See full document
8
A Nucleotide Binding Motif in Hepatitis C Virus (HCV) NS4B Mediates HCV RNA Replication
... 2A, NS4B-GFP, but not GFP, was specif- ically labeled with GTP ...fusion protein thus contains, like NS4B (6a), a potent membrane-targeting N-terminal amphipathic helix yet does not include a known ... See full document
8
Hepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune Responses
... Dengue virus NS2B/3 can bind and cleave human STING (54, ...HCV NS4B can suppress the type I inter- feron response through disruption of STING interaction with downstream signaling molecule TBK1 or MAVS ... See full document
13
Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B
... hance this NS5A modification. Thus, structural integrity of each of these proteins, forming most likely a multisubunit protein complex, is essential for differential phosphorylation of NS5A. Although ... See full document
9
A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication
... C1/H C 34 chi- mera to levels greater than that of C1/WT ...C1/H C 34 replication in a manner similar to that seen for Q1112R (data not ...H77 NS4B se- quence, there is further evidence that these ... See full document
13
NS4B Self-Interaction through Conserved C-Terminal Elements Is Required for the Establishment of Functional Hepatitis C Virus Replication Complexes
... identical protein frag- ments such as two C-terminal NS4B fragments (homotypic interactions) or by interactions between two different protein fragments such as an N-terminal and a ... See full document
14
Hepatitis C Virus Nonstructural Protein 5B Is Involved in Virus Morphogenesis
... of virus assembly (24, 49, ...NS3, NS4B, NS5A, and p7 are involved in HCV assembly and maturation (2, 15–17, 19, 20, 27, 30, ...in virus assembly is one of the unique characteristics of the family ... See full document
9
Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection
... core protein and transmem- brane glycoproteins, E1 and ...frame protein (ARFP) or F protein whose function is presently not known ...channel protein p7 [4] which is essential for virus ... See full document
12
Interaction between Nonstructural Proteins NS4B and NS5A Is Essential for Proper NS5A Localization and Hepatitis C Virus RNA Replication
... the NS4B-NS5A polyprotein junction; hence, there is a possi- bility for potential alteration of these sites, affecting the proper cleavage of ...vaccinia virus expressing T7 RNA polymerase (vTF7-3 ... See full document
14
Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy
... JC1 virus for 3 ...core protein (red) are ...HA-tagged protein-expressing ...HA-tagged protein, LC3, phosphorylated LC3 (P-LC3), and actin in the cell extracts of ... See full document
11
Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
... hydrophobic NS4B protein is unknown. How- ever, NS4B seems to be directly involved in the modulation of NS5A hyperphosphorylation (45, ...NS5A protein appears to be involved in resistance of ... See full document
14
Hepatitis C Virus F Protein Is a Short-Lived Protein Associated with the Endoplasmic Reticulum
... Hepatitis C virus (HCV) can cause severe liver diseases, including hepatitis, liver cirrhosis, and hepatocellular carci- ...This virus belongs to the flavivirus family and has a ... See full document
6
Conserved GXXXG- and S/T-Like Motifs in the Transmembrane Domains of NS4B Protein Are Required for Hepatitis C Virus Replication
... Since NS4B is a multipass transmembrane protein, its puta- tive TMDs contribute to at least one-third of the protein ...anchoring NS4B to host mem- branes, the TMDs could actively participate ... See full document
16
The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins.
... that NS4B or NS5A binds to the central region of ...for NS4B or NS5A would probably consist of not only the NS4A central region but also a certain region(s) of the NS3 serine proteinase (in the form of the ... See full document
7
Prolactin Regulatory Element Binding Protein Is Involved in Hepatitis C Virus Replication by Interaction with NS4B
... that NS4B plays an important role in the viral life cycle and pathogenesis by inter- acting with host proteins ...for NS4B-associated host membrane proteins, which are involved in HCV replication, by the ... See full document
19
Allelic Variation in the Hepatitis C Virus NS4B Protein Dramatically Influences RNA Replication
... Con1 NS4B pro- tein, the H/C N 47 and H/C C 214 chimeras exhibited lower repli- cation ...and C-terminal regions of NS4B carry out separate functions during RNA replication, ... See full document
13
Hepatitis C virus NS4B protein induces epithelial mesenchymal transition by upregulation of Snail
... E-box-binding protein) families, and reduced ex- pression of E-cadherin ...Zinc-finger protein Snail is a transcriptional factor of EMT that negatively regulates the expression of E-cadherin through binding ... See full document
9
Topology of the Membrane-Associated Hepatitis C Virus Protein NS4B
... of NS4B in eucary- otic ...HCV protein NS4B tends to localize to the ER, with a small fraction possibly localizing to the Golgi when expressed in eucaryotic ...the protein is expressed both in ... See full document
11
Charged Residues in Hepatitis C Virus NS4B Are Critical for Multiple NS4B Functions in RNA Replication
... J6-JFH1 virus was analyzed with a few ...JFH1 NS4B and a previous re- port showed that R192 is dispensable for JFH1 replication and virus production (25), only the mutations E8A, E15A, K30A, R232A, ... See full document
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