[PDF] Top 20 A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques
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A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques
... of simian immunodeficiency virus (SIV) originally derived from naturally infected sooty mangabeys (23) causes an immunodeficiency syndrome which closely resembles AIDS in human ... See full document
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Vaccination of Macaques against Pathogenic Simian Immunodeficiency Virus with Venezuelan Equine Encephalitis Virus Replicon Particles
... pigtailed macaques were vaccinated four times with SFV replicons expressing PBj14 Env gp160 ...plasma virus load, the relevance of this unique SIV-macaque model to models of SIV-induced simian ... See full document
9
Suppression of Virus Load by Highly Active Antiretroviral Therapy in Rhesus Macaques Infected with a Recombinant Simian Immunodeficiency Virus Containing Reverse Transcriptase from Human Immunodeficiency Virus Type 1
... rhesus macaques infected with a chimera (RT-SHIV) of simian immunodeficiency virus containing reverse transcriptase from human immu- nodeficiency virus type-1 ... See full document
6
T Cells Target APOBEC3 Proteins in Human Immunodeficiency Virus Type 1-Infected Humans and Simian Immunodeficiency Virus-Infected Indian Rhesus Macaques
... were defined as having asymptomatic, untreated HIV-1 infection for at least 7 years with no con- sistent decline in peripheral blood CD4 ⫹ count and low or undetectable levels of plasma viremia ( ⬍ 10,000 ... See full document
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Pathogenic Simian/Human Immunodeficiency Virus SHIVKUInoculated into Immunized Macaques Caused Infection, but Virus Burdens Progressively Declined with Time
... point, virus was not isolated again for the duration of the observation period of 135 ...become infected with challenge ...challenge virus DNA, confirmed that all animals were infected with ... See full document
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Contribution of Peaks of Virus Load to Simian Immunodeficiency Virus Pathogenesis
... in human immunodeficiency virus type 1 infection are not yet fully ...baseline virus load or the so-called viral set ...a virus load measurement from a restricted time ... See full document
6
Impairment of Gag-Specific CD8+ T-Cell Function in Mucosal and Systemic Compartments of Simian Immunodeficiency Virus mac251- and Simian-Human Immunodeficiency Virus KU2-Infected Macaques
... viral load and disease ...choriomeningitis virus infection in which it was shown that CD4 ⫹ T-cell deficiency is correlated with the presence of specific CD8 ⫹ T cells lacking effector function (46), ... See full document
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Limited Protection from a Pathogenic Chimeric Simian-Human Immunodeficiency Virus Challenge following Immunization with Attenuated Simian Immunodeficiency Virus
... the human immunodeficiency virus (HIV) scien- tific research community is attenuated ...the human population (10, 22, ...and macaques have been reported to cause little or no ... See full document
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Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239.
... Human immunodeficiency virus type 1 (HIV-1) is transmit- ted primarily by sexual contact, and to stop the HIV pandemic, a vaccine capable of preventing sexual transmission is ...the virus and ... See full document
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Generation of the Pathogenic R5-Tropic Simian/Human Immunodeficiency Virus SHIVAD8 by Serial Passaging in Rhesus Macaques
... monkeys infected with SIVmac/SIVsm lineage viruses become RPs, experiencing per- sistently high virus set points, rapid and complete losses of memory CD4 ⫹ T cells, undetectable or transient antiviral an- ... See full document
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Protection of Macaques against Pathogenic Simian/Human Immunodeficiency Virus 89.6PD by Passive Transfer of Neutralizing Antibodies
... of virus infection ...was defined as a rising titer of anti-p27 antibody over the 14-week period of the ...study. Virus replication in inguinal lymph nodes removed 2 weeks after virus ... See full document
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Control of Viremia and Prevention of Simian-Human Immunodeficiency Virus-Induced Disease in Rhesus Macaques Immunized with Recombinant Vaccinia Viruses plus Inactivated Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Particles
... attending virus challenges with highly pathogenic SHIVs ap- pear to be encouraging advancements in the quest to develop an effective vaccine against HIV-1, comparable vaccine ap- proaches, when applied to ... See full document
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Plasma viremia in macaques infected with simian immunodeficiency virus: plasma viral load early in infection predicts survival.
... in macaques infected with SIVmne, SIVmneE11S, SIVsmE660, SIVmac, and chimeric simian-human im- munodeficiency virus ...leukemia virus reverse transcriptase (50 U; Gibco BRL), the ... See full document
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Membrane-Fusing Capacity of the Human Immunodeficiency Virus Envelope Proteins Determines the Efficiency of CD4+ T-Cell Depletion in Macaques Infected by a Simian-Human Immunodeficiency Virus
... 40). Some mechanistic insights into these phenotypes have been obtained (15) and are summarized in Fig. 1. The change in isoleucine 225, within the second conserved (C2) gp120 region, does not affect the interactions of ... See full document
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Quantitation of Productively Infected Monocytes and Macrophages of Simian Immunodeficiency Virus-Infected Macaques
... of infected macrophages in both the basal ganglia and parietal cortex of the brain with viral RNA levels but not the plasma viral load was ...in human dis- ease, not all of the macaques in ... See full document
14
Coreceptor Switch in R5-Tropic Simian/Human Immunodeficiency Virus-Infected Macaques
... The human immunodeficiency virus (HIV) enters target cells via interaction of the viral glycoprotein with the cellular receptor CD4 and two principal coreceptors, CCR5 (R5 vi- ruses) and CXCR4 (X4 ... See full document
13
Peripheral NKT Cells in Simian Immunodeficiency Virus-Infected Macaques
... and human samples (3, 18, 25, 27). NKT cells were defined by gating on CD3 lymphocytes that bound to the CD1d/ ␣ -GalCer tetramer ...pigtail macaques that we were studying, most of the NKT cells ... See full document
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Immunodeficiency in the Absence of High Viral Load in Pig-Tailed Macaques Infected with Simian Immunodeficiency Virus SIVsun or SIVlhoest
... of macaques was that significant peripheral CD4 ⫹ T-cell depletion occurred long before the development of clinical AIDS (1 to 2 years ...of macaques and HIV infection of hu- mans, where the onset of AIDS ... See full document
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Persistence of Pathogenic Challenge Virus in Macaques Protected by Simian Immunodeficiency Virus SIVmacΔnef
... the simian immu- nodeficiency virus (SIV) is considered to be the best model of human immunodeficiency virus (HIV) infection in ...in macaques and is there- fore a useful tool ... See full document
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Selection of a Simian-Human Immunodeficiency Virus Strain Resistant to a Vaginal Microbicide in Macaques
... rhesus macaques is the first evidence for selection/infection by HIV or SHIV resistant to a vaginally applied ...PSC-RANTES-resistant virus was only identified in 1 of 25 macaques vaginally treated ... See full document
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