[PDF] Top 20 Pathways of activation of the Epstein-Barr virus productive cycle.

... In principle, expression of the 2.8-kb RNA could be sufficient to express both BZLF1 and BRLF1, thus activating the lytic cycle, but our results indicate simultaneous activation of both [r] ... See full document

... Quantitative PCR. DNA was isolated from cells using the QIAamp kit from Qiagen. A quantitative PCR assay of the BamW repeat region of the EBV genome was performed to measure the viral load. A BamW probe (Integrated DNA ... See full document

... In contrast, Burkitt's lymphoma-derived cell lines retaining the tumor biopsy cell phenotype express only one of the latent proteins, the nuclear antigen EBNA1; such cells do not enter t[r] ... See full document

... life cycle (16, ...cell cycle pathways leading to cell ...cell cycle progression is well established, the relationship between the lytic gene expression program and the cell cycle is ... See full document

... the pathways that are influenced by miR-155 are influenced by the direct targeting of transcrip- tional regulatory ...known activation of AP-1 by EBV as well as the role of AP-1 in the activation of ... See full document

... B activation, we assessed the distribution of the RelA/p65 subunit in cocultured cells by immunofluorescent ...signaling pathways on cell-to-cell contact-mediated EBV transmission and ... See full document

... its productive growth cycle as well and would therefore need to express lytic cycle viral functions to counteract dsRNA-dependent signal pathways that have a negative effect on viral ... See full document

... In NPC, three integration events were localized to introns of the inflammation-related genes PARK2, TNFAIP3 and CDK15, which regulate the TNF-alpha-induced apoptosis/NF-κB pathways. PARK2 deficiency promotes ... See full document

... Our results may differ from those of other investigators because of the inherent differences in the cell lines utilized. Human B cells, which are the natural host cells for latent EBV, may provide a unique environment ... See full document

... of Epstein-Barr virus (EBV) to establish latency allows it to evade the immune system and to persist for the lifetime of its host; one distinguishing characteristic is the lack of transcription of ... See full document

... productive cycle, EBV-infected epithelial cells should enter more efficiently into the productive cycle when they grow to confluence, because at this time, Ubn-1 will be sequestered outside ... See full document

... Blocking protein synthesis may benefit herpesvirus infection at different levels. First, in the absence of host protein synthesis, cel- lular ribosomes will be committed to the synthesis of viral pro- teins. Second, by ... See full document

... Since the identification of the viral gene that induces a lytic cycle in Epstein-Barr virus EBV-immortalized B cells 32, the mechanism that causes a shift from a latent to a lytic replic[r] ... See full document

... BPLF1 suppresses canonical NF-␬B-regulated genes during the EBV lytic life cycle. Expression of canonical NF- ␬ B-regulated genes, including AGT, CCL2 (monocyte chemoattractant pro- tein-1 [MCP-1]), ICAM-1, and ... See full document

... cis-acting elements which function as origins of DNA repli- cation frequently comprise an essential core component and a dispensable auxiliary component, often composed of promoter and enhancer elements (17, 29). ... See full document

... The susceptibility of the cell lines to infection by HHV-6 correlated with increased expression of various EBV proteins in that B95-8 cells, which are not susceptible to HHV-6 infection,[r] ... See full document

... cerevisiae as an experimental system to study regulation of EBV lytic cycle genes, it was first essential to determine whether ZEBRA could activate natural promoters of EBV genes that we[r] ... See full document

... lytic cycle, and BCR signaling is known to be important in plasma cell differentiation ...that activation of the BZLF1 promoter in Akata cells occurs within minutes of the antigen receptor signal, whereas ... See full document

... cell cycle and the ex- pression of genes that may control apoptosis during the infec- tion of B ...the virus to its receptor on the B-cell surface (CD21) not only mediates uptake of the virus but ... See full document

... transcription activation of one or more genes essential for DNA ...lytic cycle replication in the presence of the C189S ...transcription activation properties of Zta C189S are most consistent with a ... See full document