[PDF] Top 20 PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis
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PD-L1 expression as predictive biomarker in patients with NSCLC: a pooled analysis
... ligands, PD-L1 and PD-L2, which may be expressed by both stromal and tumor cells ...The PD-1/PD-L1 axis is an inhibitory signaling pathway, causing T-cells exhaustion and ... See full document
10
Predictive biomarkers for tumor immune checkpoint blockade
... of PD-1/PD-L1 ...for NSCLC patients with PD-L1 expression > ...with PD-L1, choosing TMB as a predictive biomarker can better ... See full document
7
The role of PD-L1 expression as a predictive biomarker: an analysis of all US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitors
... in PD-L1 ...of PD-L1 assay, PD-L1 expression cutoffs, and type of cells (tumor ...for PD-L1 ...Second, PD-L1 ex- pression is regulated by ... See full document
8
A pooled analysis of the prognostic value of PD-L1 in melanoma: evidence from 1062 patients
... of patients diagnosed with histologically confirmed melanoma; (2) detection of PD-L1 expression in the melanoma tissue using immunohistochemistry (IHC) studies; (3) identification of a ... See full document
11
<p>Tumor Mutational Burden and PD-L1 Expression in Non-Small-Cell Lung Cancer (NSCLC) in Southwestern China</p>
... estimated biomarker in ...that patients with TMB- high had prolonged PFS after they received PD-1/PD-L1 blockade, compared with patients who received ...(WES) analysis ... See full document
8
New targeted treatments for non-small-cell lung cancer – role of nivolumab
... open. Patients’ selection is currently one of the biggest issues, both for treatment opti- mization and economic ...reasons. PD-L1 expression by tumor cells seems not to be sufficient to ... See full document
15
Original Article PD-L1 expression in colon cancer and its relationship with clinical prognosis
... of PD-L1 with the clinicopathological features and prognosis of patients with colon ...that PD-L1 expression is significantly elevated in tumor ...Its expression was not ... See full document
6
Prognostic value of PD-L1 overexpression for pancreatic cancer: evidence from a meta-analysis
... of PD-L1 in pancreatic cancer (PC) remains ...between PD-L1 and ...and PD-L1 expression. Ten studies including 1,058 patients were included in the ...The ... See full document
8
Prognostic and predictive values of PD-L1 expression in patients with digestive system cancer: a meta-analysis
... We searched the PubMed, Embase, and the Chinese National Knowledge Infrastructure databases (up to June 2016) to obtain the relevant articles. The following keywords were used: “PD-L1,” “B7-H1,” “CD274,” ... See full document
10
Scoring of PD-L1 expression intensity on pulmonary adenocarcinomas and the correlations with clinicopathological factors
... in NSCLC and other malignant ...12 PD-L1 expressed on tumour cells interacts with PD-1 expressed on activated effector immune cells like cytotoxic T lymphocytes, which induces apoptosis, ... See full document
8
PD-L1 expression in human cancers and its association with clinical outcomes
... Abstract: PD-L1 is an immunoinhibitory molecule that suppresses the activation of T cells, leading to the progression of ...of PD-L1 in cancers such as gastric cancer, hepatocellular ... See full document
17
<p>A Molecular Epidemiological Analysis Of Programmed Cell Death Ligand-1 (PD-L1) Protein Expression, Mutations And Survival In Non-Small Cell Lung Cancer</p>
... between PD-L1 expression level and TMB is consistent with the expectation that more somatic mutations lead to a higher probability of neo-antigens, which is likely to attract more in fi ltrating ... See full document
13
Comprehensive immunohistochemical analysis of tumor microenvironment immune status in esophageal squamous cell carcinoma
... ligand PD-L1, expressed on antigen presenting cells and tumor cells (TCs) ...benefitted patients with some solid cancers in early clinical trials ...of biomarker analysis, ... See full document
13
Utility of PD-L1 immunohistochemistry assays for predicting PD-1/PD-L1 inhibitor response
... to PD-L1 inhibition was noted [55, ...to PD-1/PD-L1 in- hibition in ...the expression of ...of PD-L1 synthesis and expression in NSCLC ...when ... See full document
6
Host expression of PD L1 determines efficacy of PD L1 pathway blockade–mediated tumor regression
... of patients across many cancer histologies (1, 2). Clinical response to PD-L1 and PD-1 blockade has been associated with increased PD-L1 expression in the tumor tissues, ... See full document
12
<p>Conformance Assessment of PD-L1 Expression Between Primary Tumour and Nodal Metastases in Non-Small-Cell Lung Cancer</p>
... with PD-1/ PD-L1 targeted therapies, 3 albeit these are observed only in a small percentage of ...each PD-1/PD-L1 inhibitor, a speci fi c PD-L1 immunohistochemistry ... See full document
7
Upregulation of PD-L1 and APE1 is associated with tumorigenesis and poor prognosis of gastric cancer
... correlation analysis of clinical data characteristics and OS using the Kaplan–Meier method demonstrated that there was no significant correlation between age, sex, and OS of ...the analysis of tumor ... See full document
9
PD-L1 expression is a predictive biomarker for CIK cell-based immunotherapy in postoperative patients with breast cancer
... the patients had completed comprehensive treatment and when routine blood examination had returned to normal, a sample of heparinized peripheral blood (50–60 mL) was ...phenotypic analysis and the detection ... See full document
14
Review of checkpoint immunotherapy for the management of non-small cell lung cancer
... In patients with cancer, tumor cells can also serve as ...activation, PD-1 expression is ...stimulation, PD-L1 signals through T-cell PD-1 to “turn off” T-cells in order to ... See full document
13
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... for PD-L1 was carried out using a DAKO Autostainer Link 48 and monoclonal mouse anti-PD-L1 clone 22C3 PharmDx (Dako, Carpinteria, ...positive PD-L1 staining was defined as either ... See full document
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