[PDF] Top 20 Persistence of Pathogenic Challenge Virus in Macaques Protected by Simian Immunodeficiency Virus SIVmacΔnef
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Persistence of Pathogenic Challenge Virus in Macaques Protected by Simian Immunodeficiency Virus SIVmacΔnef
... hybrid virus became the sole form detected after its first identification, suggesting that it has a selective ...hybrid virus was less infectious than even the vaccine SIVmac251⌬nef strain (data not shown), ... See full document
9
Detection of simian immunodeficiency virus (SIV)-specific CD8+ T cells in macaques protected from SIV challenge by prior SIV subunit vaccination.
... infectious virus, the absence of a detectable serologic response to SIV postchallenge, and the long-term health of the ...additional macaques if samples were examined at earlier and more fre- quent time ... See full document
7
With Minimal Systemic T-Cell Expansion, CD8+ T Cells Mediate Protection of Rhesus Macaques Immunized with Attenuated Simian-Human Immunodeficiency Virus SHIV89.6 from Vaginal Challenge with Simian Immunodeficiency Virus
... SIV challenge, both T-cell proliferation and T-cell death were blunted in the immunized monkeys com- pared to the unimmunized ...of challenge eliminated the SIV-specific CD8 ⫹ T-cell response in most ... See full document
16
Outcome of Simian-Human Immunodeficiency Virus Strain 89.6p Challenge following Vaccination of Rhesus Macaques with Human Immunodeficiency Virus Tat Protein
... cynomolgus macaques, five of seven animals with humoral and cellular immune responses elicited by vaccination with Tat protein using ribi or alum as an adjuvant were protected against intravenous ... See full document
10
Acute Effects of Pathogenic Simian-Human Immunodeficiency Virus Challenge on Vaccine-Induced Cellular and Humoral Immune Responses to Gag in Rhesus Macaques
... SHIV challenge. Four groups of rhesus macaques were immunized three times each against the SIV capsid antigen prior to SHIV challenge (Table ...to virus challenge by ...before ... See full document
7
Pathogenic Simian/Human Immunodeficiency Virus SHIVKUInoculated into Immunized Macaques Caused Infection, but Virus Burdens Progressively Declined with Time
... point, virus was not isolated again for the duration of the observation period of 135 ...in challenge virus DNA, confirmed that all animals were infected with SHIV KU ... See full document
9
Protection of Macaques against Pathogenic Simian/Human Immunodeficiency Virus 89.6PD by Passive Transfer of Neutralizing Antibodies
... of virus infection ...study. Virus replication in inguinal lymph nodes removed 2 weeks after virus challenge was assessed by in situ hybridization ... See full document
10
Antibody Protects Macaques against Vaginal Challenge with a Pathogenic R5 Simian/Human Immunodeficiency Virus at Serum Levels Giving Complete Neutralization In Vitro
... human immunodeficiency virus (HIV-1) vaccine design is the efficacy of antibodies in preventing mucosal transmission of R5 ...Vaginal challenge of macaques with chimeric simian/human ... See full document
8
A Vaccine against CCR5 Protects a Subset of Macaques upon Intravaginal Challenge with Simian Immunodeficiency Virus SIVmac251
... in macaques, induces antibodies that bind to native macaque CCR5 and block virus infection in vitro ...of macaques with the CCR5 vaccine reduced viral loads and time to clearance in pig-tailed ... See full document
14
Effect of CD8+ Lymphocyte Depletion on Virus Containment after Simian Immunodeficiency Virus SIVmac251 Challenge of Live Attenuated SIVmac239Δ3-Vaccinated Rhesus Macaques
... a challenge with the pathogenic Friend virus ...vaccine virus by cellular responses limited the antigen exposure necessary for the induction of humoral ...of pathogenic virus ... See full document
11
Multi-Low-Dose Mucosal Simian Immunodeficiency Virus SIVmac239 Challenge of Cynomolgus Macaques Immunized with “Hyperattenuated” SIV Constructs
... from pathogenic low-dose SIVmac239 mucosal ...replication-competent virus-like particles containing all the viral structural proteins and pos- sessing morphology typical of wild-type virus ...both ... See full document
14
Comparative Efficacy of Recombinant Modified Vaccinia Virus Ankara Expressing Simian Immunodeficiency Virus (SIV) Gag-Pol and/or Env in Macaques Challenged with Pathogenic SIV
... vaccinia virus and SIV antigens were monitored in sequen- tial plasma samples by ELISA ...expected, macaques immunized with MVA-gag-pol or MVA did not de- velop Env-specific ...in macaques immu- ... See full document
12
Rhesus macaques previously infected with simian/human immunodeficiency virus are protected from vaginal challenge with pathogenic SIVmac239.
... Human immunodeficiency virus type 1 (HIV-1) is transmit- ted primarily by sexual contact, and to stop the HIV pandemic, a vaccine capable of preventing sexual transmission is ...the virus and the ... See full document
11
Macaques immunized with HLA-DR are protected from challenge with simian immunodeficiency virus.
... not protected. In previous experi- ments only 50% of the macaques immunized with uninfected human cells were protected from a subsequent challenge with SIV grown in the same cells ...the ... See full document
8
Limited Protection from a Pathogenic Chimeric Simian-Human Immunodeficiency Virus Challenge following Immunization with Attenuated Simian Immunodeficiency Virus
... the virus to grow less efficiently and to induce a diminished immune response ...immunizing virus to cause damage to the immune system and second by the level of the immunity gen- erated following ... See full document
9
Vaccination of Macaques against Pathogenic Simian Immunodeficiency Virus with Venezuelan Equine Encephalitis Virus Replicon Particles
... influenza virus (HA-VRP) gives complete protection against a lethal intranasal challenge with influenza virus ...block challenge virus replication at the level of the mucosal target, ... See full document
9
Simian immunodeficiency virus DNA vaccine trial in macaques.
... of simian immunodeficiency virus-macaque (SIVmac) proteins has been evaluated for the ability to protect against a highly pathogenic uncloned SIVmac251 ...uncloned challenge ... See full document
14
Novel Adeno-Associated Virus Vector Vaccine Restricts Replication of Simian Immunodeficiency Virus in Macaques
... vaccine virus (SIVsm/H4) were also measured ...After challenge, an anam- nestic response was seen in a single animal, while titers either declined (three of eight animals) or remained stable (four of eight ... See full document
11
Rev-Independent Simian Immunodeficiency Virus Strains Are Nonpathogenic in Neonatal Macaques
... Virus isolations were performed using a cocultivation assay in CEMx174 cells (for the Nef-negative group) and analyzed by antigen capture assay or by using engineered CEMx174-GFP cells (Nef-positive group) and ... See full document
9
Immune response of rhesus macaques to recombinant simian immunodeficiency virus gp130 does not protect from challenge infection.
... Because of safety concerns in the use of inactivated and live whole-virus vaccines, we evaluated the protective immunity of vaccinia virus recombinants expressing the surface glycoprotei[r] ... See full document
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