[PDF] Top 20 Physical and functional interactions between herpes simplex virus immediate-early proteins ICP4 and ICP27.
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Physical and functional interactions between herpes simplex virus immediate-early proteins ICP4 and ICP27.
... of ICP4 to form a stable DNA-protein complex on the noncanonical TKB site but not on a high- affinity binding site ...that ICP4 overexpres- sion in 293 cells overcomes the ICP27 requirement for ... See full document
11
Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins
... the ICP27 sequences in the viruses, elec- trophoretically separated HpaI fragments of the viral DNA were probed with the indicated ...the ICP27 locus, all the mutant viruses contained the shortened HpaI ... See full document
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Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells.
... positioned ICP4 binding sites tar- get promoters for repression by ICP4 (57, 61, 81, 82), specific binding sites are not required for transactivation (42, 52, 89), which appears to be mediated through ... See full document
10
Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22.
... Very early in infection, herpes simplex virus (HSV) expresses four immediate-early (IE) regulatory proteins, ICP4, ICP0, ICP22, and ...IE proteins in cis, ... See full document
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Arginine Methylation of the ICP27 RGG Box Regulates the Functional Interactions of ICP27 with SRPK1 and Aly/REF during Herpes Simplex Virus 1 Infection
... The herpes simplex virus 1 (HSV-1) protein ICP27 is a multifunctional regulatory protein that acts at the transcrip- tional and posttranscriptional ...Posttranscriptionally, ICP27 ... See full document
6
Functional and Physical Interactions of the Herpes Simplex Virus Type 1 UL20 Membrane Protein with Glycoprotein K
... recombinant virus, ⌬ 20/gKD3prtC, was constructed by replacing the UL20 gene of the recombinant virus gKD3prtC (17) with a gene cassette expressing the EGFP gene under control of the cytomegalovirus ... See full document
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Control of VP16 Translation by the Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27
... links between the EJC, splicing, and translation have recently been ...that ICP27 could modulate the function of this protein in HSV-infected cells and thereby influence the translational ef- ficiencies of ... See full document
12
Binding of ICP4, TATA-Binding Protein, and RNA Polymerase II to Herpes Simplex Virus Type 1 Immediate-Early, Early, and Late Promoters in Virus-Infected Cells
... of ICP4 to the formation of transcription complexes on HSV promoters representative of different kinetic ...that ICP4 recruits the cellular transcription machinery to activate promoters in the context of ... See full document
11
Evidence that the Immediate-Early Gene Product ICP4 Is Necessary for the Genome of the Herpes Simplex Virus Type 1 ICP4 Deletion Mutant Strain d120 To Circularize in Infected Cells
... (A) ICP4 expression in d120- infected Vero and E5 ...with ICP4-deleted mutant d120 or wild-type KOS as indicated at an MOI of ...to ICP4 and actin, respectively, as described in Materials and ... See full document
9
Neurons Differentially Activate the Herpes Simplex Virus Type 1 Immediate-Early Gene ICP0 and ICP27 Promoters in Transgenic Mice
... The ICP4 promoter was activated in large numbers of trigeminal ganglion neurons of newborn ICP4--galactosidase transgenic mice (Tg6305) ...adult ICP27--galactosidase transgenic mice (Tg3054) had ... See full document
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CK2 Protein Kinase Is Stimulated and Redistributed by Functional Herpes Simplex Virus ICP27 Protein
... a herpes simplex virus type 1 (HSV-1) phospho- protein of 63 kDa which is essential for viral replication and expression of certain early and late viral genes (reviewed in reference 35) and is ... See full document
11
Recruitment of Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 to the Virus Particle
... protein ICP27, and failure of ICP0 to translocate in this ICP27- dependent manner abrogates its assembly into the virion ...for physical recruitment into the virion, but where and how this ... See full document
15
Functional Comparison of Herpes Simplex Virus 1 (HSV-1) and HSV-2 ICP27 Homologs Reveals a Role for ICP27 in Virion Release
... of ICP27, an immediate-early (IE) protein of herpes simplex virus 1 ...and ICP27. In transfection-based assays, ICP27t2 closely resembled ICP27 in its capacity to ... See full document
14
Cooperativity among herpes simplex virus type 1 immediate-early regulatory proteins: ICP4 and ICP27 affect the intracellular localization of ICP0.
... To identify the region of the ICPO molecule that responds to ICP27, Vero cells were cotransfected with 1 ,ug of pSH or 1 ,ug of the ICPO nonsense mutant plasmids pn428, pn525, pn680, pn7[r] ... See full document
14
Overexpression of the herpes simplex virus type 1 immediate-early regulatory protein, ICP27, is responsible for the aberrant localization of ICP0 and mutant forms of ICP4 in ICP4 mutant virus-infected cells.
... IE proteins and cooperative interactions among these proteins play key roles in regulating HSV-1 gene ...the functional cooperativity among them are not ...for functional cooperat- ... See full document
11
Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27 Is Required for Efficient Incorporation of ICP0 and ICP4 into Virions
... and ICP4 in the tegument layer of WT ...light-scattering virus band was ob- served, consistent with the published analysis of extracellular virions prepared from Vero cells by this procedure ...and ... See full document
10
Physical interaction between the herpes simplex virus type 1 immediate-early regulatory proteins ICP0 and ICP4.
... Using GST-ICPO fusion protein affinity chromatography and in vitro-synthesized [35S]Met-labeled ICPO and ICP4, ICP4 was shown to interact preferentially with the fusion protein containin[r] ... See full document
11
Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4.
... infection, ICP4 exists in multiple forms with slight variations in electrophoretic mobilities, presumably as a result of differential phosphorylation ...(75). ICP27 has been shown to subtly affect the ... See full document
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Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4.
... Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4.. Activation of immediate-early, early, and[r] ... See full document
12
Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene.
... A mutated ICP4 protein expressed from the viral genome that retains the ability to bind to a consensus binding site but does not bind specifically to the identified sites flanking the tk[r] ... See full document
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