[PDF] Top 20 Polyomavirus Large T Antigen Binds Cooperatively to Its Multiple Binding Sites in the Viral Origin of DNA Replication
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Polyomavirus Large T Antigen Binds Cooperatively to Its Multiple Binding Sites in the Viral Origin of DNA Replication
... stimulates binding of polyomavirus large T antigen to an origin DNA fragment at pH ...filter binding assay, but found no effect of ATP on binding at pH 7 or ... See full document
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The Minimum Replication Origin of Merkel Cell Polyomavirus Has a Unique Large T-Antigen Loading Architecture and Requires Small T-Antigen Expression for Optimal Replication
... LT binding to the origin, other viral fac- tors and motifs were found to be critical for efficient MCV DNA ...in origin replication (8, 9, ...the origin replication ... See full document
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Elements of the polyomavirus replication origin required for homologous recombination mediated by large T antigen.
... B binding sites, the insert contained an Sp1 binding ...with polyomavirus large T-ag with and without various Rel/ k B expression ...a replication assay, the p k B4 ... See full document
5
Polyomavirus Large T Antigen Binds the Transcriptional Coactivator Protein p300
... p300 binding, and the T antigens from SV40 and polyomavirus, in which ill-defined domains within the C-terminal parts of the proteins play a role in interactions with p300, points once more to ... See full document
6
Activation of CREB/ATF Sites by Polyomavirus Large T Antigen
... tested its ability to activate the ⫺ 37/ ⫺ 33 cyclin A ...in large T, namely, the ...allow DNA binding (78). However, the specific activity of large T truncated at residue ... See full document
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Characterization of the DNA-Binding Properties of the Origin-Binding Domain of Simian Virus 40 Large T Antigen by Fluorescence Anisotropy
... Small DNA tumor viruses such as simian virus 40 (SV40), polyomavirus, or papillomavirus have become important model systems for the study of molecular events involved in DNA ...protein, large ... See full document
7
Polyomavirus Middle T-Antigen Is a Transmembrane Protein That Binds Signaling Proteins in Discrete Subcellular Membrane Sites
... double-stranded DNA (dsDNA) genome coated with cell histones and surrounded by three virally encoded virion proteins ...the T-antigens that alter the infected cell in order to provide a suitable environment ... See full document
9
The Retinoblastoma Protein Alters the Phosphorylation State of Polyomavirus Large T Antigen in Murine Cell Extracts and Inhibits Polyomavirus Origin DNA Replication
... regulating viral DNA ...to sites of viral replication in herpesvirus- infected ...SV40 T Ag, prevents assembly of T Ag hexamers at the core origin and also ... See full document
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Murine polyomavirus and simian virus 40 large T antigens produce different structural alterations in viral origin DNA.
... of DNA replication involves recogni- tion of the origin of replication by a site-specific DNA-binding protein, which then, in the presence of nucleotide, induces sufficient ... See full document
7
Host DNA Damage Response Factors Localize to Merkel Cell Polyomavirus DNA Replication Sites To Support Efficient Viral DNA Replication
... cell polyomavirus (MCPyV) in the development of Merkel cell carcinoma (MCC), making MCPyV the first polyomavirus to be clearly associated with human ...and its oncogenic ...host DNA damage ... See full document
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The E1 Initiator Recognizes Multiple Overlapping Sites in the Papillomavirus Origin of DNA Replication
... SV40 T antigen and papillomavirus E1 proteins suggests that common mechanisms are used by these viruses in the assembly of active initiator ...Like T antigen, the E1 protein recognizes and ... See full document
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Polyomavirus Large T Antigen Binds Symmetrical Repeats at the Viral Origin in an Asymmetrical Manner
... 5 Replication assays. (A) Origin sequences of wild-type and mutant A2 and NG59RA origin ...NG59RA polyomavirus origin-containing plasmid pFLORI40 or their respective mutants P1, P2, P3, ... See full document
9
Phosphorylation sites in polyomavirus large T antigen that regulate its function in viral, but not cellular, DNA synthesis.
... for viral DNA ...to large T function. Since there is already evidence connecting large T phosphorylation to viral DNA replication (2, 9, 39, 49), in vivo ... See full document
7
Polyomavirus large T antigen binds independently to multiple, unique regions on the viral genome.
... To test the applicability of this method for measuring the binding of polyomavirus large T antigen to specific viral DNA fragments, we incubated increasing amounts of nuclear extract fro[r] ... See full document
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Sequences flanking the pentanucleotide T-antigen binding sites in the polyomavirus core origin help determine selectivity of DNA replication.
... cis-acting origin of DNA replication, with its auxiliary DNA elements, and the trans-acting viral large tumor antigen (T ...a replication complex ... See full document
9
Cyclin-dependent kinase regulation of the replication functions of polyomavirus large T antigen.
... low-molecular-weight DNA ex- tracted from transfected cells ...of viral DNA replication occurred at 48 h after transfection with 100 ng of DNA (data not ...DpnI-resistant DNA ... See full document
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Studies on the origin-specific DNA-binding domain of simian virus 40 large T antigen.
... Similar treatment of the truncated 259.3 protein produced in HeLa cells resulted in only a slight if any increase in binding to both wt origin- and site Il-containing fragments.. Two int[r] ... See full document
5
A subclass of polyomavirus middle tumor antigen binds to DNA cellulose.
... When extracts of BMT-1 cells were bound to either native or denatured calf thymus DNA cellulose at pH 6.0, it was found that both columns reproducibly retained similar quantities of M-T [r] ... See full document
8
High-frequency recombination mediated by polyomavirus large T antigen defective in replication.
... We show here that in another cell line, designated Hy5, polyomavirus large T-Ag can promote different recombination events independently of its replicative function and that recombinatio[r] ... See full document
8
Simian Virus 40 Large T Antigen Can Specifically Unwind the Central Palindrome at the Origin of DNA Replication
... does T antigen specifically unwind the site II sequence? Modeling of the presumptive double hexamer structure over 31-bp DNA using published structure information (3, 20, 25, 28, 29, 35, 36) shows ... See full document
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