[PDF] Top 20 Role of Polypyrimidine Tract Binding Protein in the Function of the Hepatitis B Virus Posttranscriptional Regulatory Element
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Role of Polypyrimidine Tract Binding Protein in the Function of the Hepatitis B Virus Posttranscriptional Regulatory Element
... PTB binding in PRE function. The binding of PTB to fragment III does not necessarily reflect a role for PTB in PRE ...PTB binding, we performed two sets of ...PTB binding on PRE ... See full document
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The Polypyrimidine Tract Binding Protein Is Required for Efficient Picornavirus Gene Expression and Propagation
... the function of viral and cellular IRESs in vitro, a requirement for PTB in vivo remains contro- versial (23, 28, 34, 38, 40, ...encephalomyocarditis virus (EMCV) IRES only twofold (23, 28), whereas PTB ... See full document
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Expression analysis of the polypyrimidine tract binding protein (PTBP1) and its paralogs PTBP2 and PTBP3 during Xenopus tropicalis embryogenesis
... (polypyrimidine tract binding protein) family of RNA-binding proteins plays a critical role in development through the regulation of post-transcriptional ...a role in the ... See full document
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Original Article Inhibition of hepatitis B virus in HepG2.2.15 by indirubin through suppression of a polypyrimidine tract-binding protein
... RNA-binding protein. In the nucleus, its main function is to regulate the alternative splicing of many pre-mRNAs [26, ...the protein can be shuttled from the nucleus to the cytoplasm [28]. The ... See full document
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Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements.
... A1 binding to a specific site within U5 RNA corre- lates with CRS function mediated by the ...A1 binding site, UAGGG(A/U), had been recently described (53), we performed site-directed and small ... See full document
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Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation.
... IRES function requires factors other than those involved in translation initiation of eukaryotic ...the binding of PTB to the 5 9 NCR of the ...PTB binding may be focused more on structural motifs ... See full document
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Polypyrimidine Tract-Binding Protein Binds to the Leader RNA of Mouse Hepatitis Virus and Serves as a Regulator of Viral Transcription
... cellular protein, previously described as p55, binds specifically to the plus strand of the mouse hepatitis virus (MHV) leader ...this protein and determined by partial peptide sequencing that ... See full document
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Hepatitis B Virus X Protein Function Requires Zinc Binding
... HBx protein (7, 8, ...HBx function, there is still much to learn about this viral regulatory ...Zinc binding plays a key structural role FIG 5 Identification of cysteine and histidine ... See full document
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HuR Displaces Polypyrimidine Tract Binding Protein To Facilitate La Binding to the 3′ Untranslated Region and Enhances Hepatitis C Virus Replication
... the role of HuR in HCV repli- cation, partial silencing of HuR was achieved using siRNAs target- ing the ...HCV-NS3 protein levels were also reduced considerably, indicating that there is a decrease in ... See full document
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Identification of an effective siRNA target site and functional regulatory elements, within the hepatitis B virus posttranscriptional regulatory element
... to function in the context of heterologous genes by enhancing expression of intron- less transcripts of b -globin and c- myc ...Luc+ protein (Figure ...the function of these PRE elements in a ... See full document
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Prolactin Regulatory Element Binding Protein Is Involved in Hepatitis C Virus Replication by Interaction with NS4B
... or virus inhibition by siPREB treatment was observed ...and B), possibly because HCV DMVs have been shown to be relatively stable and preexist- ing PREB proteins exert a role to promote HCV ... See full document
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Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances Expression of Transgenes Delivered by Retroviral Vectors
... polypurine tract (Fig. 1A). To produce vesicular stomatitis virus G protein (VSV-G)-pseudotyped transducing particles, vector plasmids with or without the WPRE were cotransfected into 293T cells with ... See full document
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The Transcriptional Transactivation Function of HBx Protein Is Important for Its Augmentation Role in Hepatitis B Virus Replication
... negative regulatory domain at its N termi- nus and a transactivation domain (also called the coactivation domain) at its C ...DNA binding property, therefore, it is not a typical ...through ... See full document
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Woodchuck Hepatitis Virus Contains a Tripartite Posttranscriptional Regulatory Element
... HBV posttranscriptional regulatory element (HBVPRE) is an orientation-dependent cis-acting RNA element that par- tially overlaps with enhancer I and is required for the cytoplas- mic ... See full document
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Leptomycin B Inhibits Equine Infectious Anemia Virus Rev and Feline Immunodeficiency Virus Rev Function but Not the Function of the Hepatitis B Virus Posttranscriptional Regulatory Element
... immunodeficiency virus type 1 (HIV-1) Rev and human T-cell leukemia virus type 1 Rex bind their respective RNA response elements, the Rev response element (RRE) and the Rex response element, ... See full document
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The hepatitis B virus posttranscriptional regulatory element is composed of two subelements.
... PRE b represent RNA binding sites for cellular RNA export ...PRE b are recog- nized by a single cellular protein or if different proteins asso- ciate with each ...PRE b support the ... See full document
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Cloning and Characterization of a Novel Hepatitis B Virus x Binding Protein That Inhibits Viral Replication
... cellular protein(s) may be required in the cytoplasm and the nucleus for HBx to exert its biologic function(s) within the ...of protein- protein interactions, several have been reported to ... See full document
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Effects of sterol regulatory element-binding protein (SREBP) in chickens
... important role of SREBP-1 in the regulation of lipogen- esis, which has until now been mainly described in mam- mals ...SREBP-1 protein. This finding suggests a direct role for SREBP-1 in the ... See full document
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Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein.
... polio- virus have been described, including eIF-2 (3), pyrimidine tract-binding protein (pPTB) (12, 29), La (21), p100 (13), p48/ 50, p38/39, and p35/36 (4, 6, 11, 25), and p60 ...a ... See full document
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Enhancement of Hepatitis B Virus Replication by the Regulatory X Protein In Vitro and In Vivo
... FIG. 2. HBx-dependent replication in the livers of hydrodynami- cally injected mice. (A) Quantitation of capsid-associated DNA by Southern blot hybridization and densitometer scanning. The amount of capsid-associated HBV ... See full document
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