[PDF] Top 20 Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences.
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Positive control of the herpes simplex virus thymidine kinase gene requires upstream DNA sequences.
... HALPERN Pathology Department, McMaster University, Hamilton, Ontario, Canada L8N 3Z5 We examined the ability of deleted versions of the herpes simplex virus type 1 thymidine kinase gene,[r] ... See full document
10
Splicing-Independent Expression of the Herpes Simplex Virus Type 1 Thymidine Kinase Gene Is Mediated by Three cis-Acting RNA Subelements
... intron-dependent gene expression has, in large part, been inseparable from that of intron-independent gene ...b-globin gene expression also studied the intron in- dependence of the thymidine ... See full document
8
Identification of the herpes simplex virus DNA sequences present in six herpes simplex virus thymidine kinase-transformed mouse cell lines.
... The studies described in this paper were designed to both unambiguously map the HSV-1 and HSV-2 tk genes and to study the patterns of incorporation of non-tk gene viral DNA sequences in [r] ... See full document
14
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes.
... Chimeric genes constructed by fusion of the coding and 5' nontranslated leader sequences of the thymidine kinase TK gene to the sequences upstream from the site of initiation of transcri[r] ... See full document
11
Low-Level Expression and Reversion both Contribute to Reactivation of Herpes Simplex Virus Drug-Resistant Mutants with Mutations on Homopolymeric Sequences in Thymidine Kinase
... midi-prep DNA (Wizard Prep; Promega), virion “mini-prep” (7) tkLTRZ1 DNA, and transfec- tion reagent (Effectene; QIAGEN) were added to 50% confluent Vero ...leukemia virus long terminal repeat (LTR) ... See full document
7
Mutation Spectra of Herpes Simplex Virus Type 1 Thymidine Kinase Mutants
... TK positive and would evade detection by TK mutagenesis ...tk gene is predicted to be higher, since other regions of TK may exhibit a much higher plasticity for substi- tuted amino acids without altering TK ... See full document
7
Replication Fidelity of the supF Gene Integrated in the Thymidine Kinase Locus of Herpes Simplex Virus Type 1
... It requires intricate DNA replication machinery that both duplicates chromosomal DNA and maintains genomic ...enzymes, DNA polymerases (Pols) are critical for ensuring the accuracy of ... See full document
10
Diverse Herpes Simplex Virus Type 1 Thymidine Kinase Mutants in Individual Human Neurons and Ganglia
... the thymidine kinase gene (tk) of herpes simplex virus type 1 (HSV-1) explain most cases of virus resistance to acyclovir (ACV) ...tk sequences in human ... See full document
10
Identification and mapping of two polypeptides encoded within the herpes simplex virus type 1 thymidine kinase gene sequences.
... McGEOCH Medical Research Council Virology Unit, Glasgow, Gll 5JR Scotland mRNA's homologous to the herpes simplex virus type 1 DNA restriction endonuclease fragment BamHI p, which contai[r] ... See full document
13
An unusual internal ribosome entry site in the herpes simplex virus thymidine kinase gene
... For sequences that support ‘‘standard’’ levels of Fluc expression ( ⱖ 1%), the bars are ...For sequences that support ‘‘intermediate’’ levels of Fluc expression ( ⱖ ...For sequences that have low or ... See full document
7
Transcription of herpes simplex virus genes in vivo: overlap of a late promoter with the 3' end of the early thymidine kinase gene.
... 10-17 0022-538X/82/010010-08$02.00/0 Copyright © 1982, American Society for Microbiology Transcription of Herpes Simplex Virus Genes In Vivo: Overlap of a Late Promoter with the 3' End o[r] ... See full document
8
Factors Governing Expression of the Herpes Simplex Virus Gene for Thymidine Kinase in Clonal Derivatives of Transformed Mouse L Cells
... Because the synthesis of viral tk in cells productively infected with tk+ HSV-1 requires the prior synthesis of a proteins 8, 11, 32 and because expression of an a protein appears to be [r] ... See full document
14
Examination of the roles of transcription factor Sp1-binding sites and an octamer motif in trans induction of the herpes simplex virus thymidine kinase gene.
... Several observations made attractive the hypothesis that increases in the activity or availability of Spl mediate trans induction: i experiments in which tk promoter sequences were fused[r] ... See full document
5
Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1.
... SCOLNICK'* Laboratory of Tumor Virus Genetics, National Cancer Institute, Bethesda, Maryland 20205,' and Department of Microbiology, University of Chicago, Chicago, Illinois 606372 We co[r] ... See full document
10
Herpes simplex virus gene expression in transformed cells. I. Regulation of the viral thymidine kinase gene in transformed L cells by products of superinfecting virus.
... The treatment of the LVtk+ cells with phosphonoacetic acid alone or with cytosine arabinoside alone, in the absence of HSV-ltk- infection, did not cause an enhancement in viral tk activi[r] ... See full document
12
Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.
... Thus, the effect of mutations in the tk promoter binding sites for cellular transcription factors could be directly monitored in the absence and presence of ICP4 in the context of viral [r] ... See full document
10
Thymidine kinase-deficient herpes simplex virus type 2 genital infection in guinea pigs.
... Our observation that latent virus may also be recovered from external genital skin and uterine cervix after recovery from HSV-2 genital infection suggests that extraneural latent virus m[r] ... See full document
7
Anatomy of herpes simplex virus DNA. V. Terminally repetitive sequences.
... The procedures for purification of viral DNA were the same as reported 503 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Native DNA from four strains of herpes simple[r] ... See full document
10
A conserved open reading frame that overlaps the herpes simplex virus thymidine kinase gene is important for viral growth in cell culture.
... Nucleotide sequence of the herpes simplex virus type 2 HSV-2 thymidine kinase gene and predicted amino acid sequence of thymidine kinase polypeptide and its comparison with the HSV-1 thy[r] ... See full document
5
Virus Type-Specific Thymidine Kinase in Cells Biochemically Transformed by Herpes Simplex Virus Types 1 and 2
... Virus stocks were prepared as described previously 13, except that viruses were grown in monolay140 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Transformation of mo[r] ... See full document
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