[PDF] Top 20 Possible Role of Dimerization in Human Immunodeficiency Virus Type 1 Genome RNA Packaging
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Possible Role of Dimerization in Human Immunodeficiency Virus Type 1 Genome RNA Packaging
... HIV-1 genome, whereas that of pDDN was ⬎1,000 bases long, from the 5⬘ end to the middle of the gag ...The RNA encapsidation and dimerization abilities of the virions were compared with those ... See full document
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The Human Immunodeficiency Virus Type 1 Gag Polyprotein Has Nucleic Acid Chaperone Activity: Possible Role in Dimerization of Genomic RNA and Placement of tRNA on the Primer Binding Site
... several RNA-RNA interaction events. In partic- ular, the genomic RNA molecules form a dimeric structure, and a cellular tRNA molecule is annealed to an 18-base complementary region (the primer ... See full document
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Nonreciprocal Packaging of Human Immunodeficiency Virus Type 1 and Type 2 RNA: a Possible Role for the p2 Domain of Gag in RNA Encapsidation
... The chimeric proviral constructs, pSVRM1 and pSVRM2, were made as follows. An AatII-XhoI (nucleotide [nt] 2032) fragment containing the HIV-2 59 long terminal repeat, the untranslated region, and gag was cloned from pSVR ... See full document
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Nucleocapsid and Matrix Protein Contributions to Selective Human Immunodeficiency Virus Type 1 Genomic RNA Packaging
... major role in genomic RNA packaging, and some evidence has implicated the matrix protein (MA) of certain retroviruses in viral RNA ...the role of NC in the selective recognition of ... See full document
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A Hairpin Structure in the R Region of the Human Immunodeficiency Virus Type 1 RNA Genome Is Instrumental in Polyadenylation Site Selection
... The human immunodeficiency virus type 1 (HIV-1) genome encodes an inherently efficient polyadenylation signal within the 97-nucleotide R ...secondary RNA structure ... See full document
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A conserved hairpin motif in the R-U5 region of the human immunodeficiency virus type 1 RNA genome is essential for replication.
... the human immunodeficiency virus (HIV) RNA genome contains multiple hairpin ...the RNA molecule, encodes the well-known TAR hairpin and a second hairpin structure with the ... See full document
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Dissociation of Genome Dimerization from Packaging Functions and Virion Maturation of Human Immunodeficiency Virus Type 1
... wild type (see ...its RNA, since the infectivities of other mutants that showed various RNA profiles also displayed the same magnitude of ...viral RNA could be the template for reverse ... See full document
9
Analysis of Human Immunodeficiency Virus Type 1 Gag Dimerization-Induced Assembly
... essential role in virus ...viral RNA promotes dimerization of PrGag capsid (CA) domains, which triggers assembly of CA N-terminal domains (NTDs) into hexamer rings that are intercon- nected by ... See full document
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Mechanisms of Human Immunodeficiency Virus Type 2 RNA Packaging: Efficient trans Packaging and Selection of RNA Copackaging Partners
... The role of the 6-nt palindromic sequence in RNA dimeriza- tion has been the subject of controversy; although in vitro experiments have shown that this 6-nt RNA motif is important for RNA ... See full document
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Maintenance of the Gag/Gag-Pol Ratio Is Important for Human Immunodeficiency Virus Type 1 RNA Dimerization and Viral Infectivity
... the human immunodeficiency virus type 1 (HIV-1) Gag-Pol precursor protein results from a ⴚ 1 ribosomal frameshifting ...in virus-producing cells by cotransfecting ... See full document
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Trans-packaging of human immunodeficiency virus type 1 genome into Gag virus-like particles in Saccharomyces cerevisiae
... HIV-1 gag mRNA is identical to its genomic RNA and contains the R-U5-SL region at its 5 0 end. It is well docu- mented that the R-U5-SL region forms a highly folded and complicated structure [28-31]. To ... See full document
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Functional Characterization of the Human Immunodeficiency Virus Type 1 Genome by Genetic Footprinting
... the human immunodeficiency virus type 1 (HIV-1) RNA ...viral genome contains several important cis-acting sequences, including the TAR, polyadenylation, viral att ... See full document
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Effects of Mutations in the Human Immunodeficiency Virus Type 1 gag Gene on RNA Packaging and Recombination
... genomic RNA is selectively encap- sidated into virions through interactions between RNA and the Gag polyproteins (15, 20, ...38). Human immunodeficiency virus type 1 ... See full document
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The Human Immunodeficiency Virus Type 1 TAR RNA Upper Stem-Loop Plays Distinct Roles in Reverse Transcription and RNA Packaging
... the role of TAR in reverse transcription is dependent on its secondary ...alternative RNA structures that stabilize the reverse transcription com- ...TAR RNA upper stem-loop structure is the binding ... See full document
8
Human Immunodeficiency Virus Type 1 Escape Is Restricted When Conserved Genome Sequences Are Targeted by RNA Interference
... the possible viral escape routes are ideal shRNA candidates to be used in such a combination ...therapy. Virus escape studies also provide some insight into the mechanism of RNAi, in particular the ... See full document
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Is HIV 1 RNA dimerization a prerequisite for packaging? Yes, no, probably?
... immature virus particles [114]. This might mean that either the RNA struc- ture, or the lack of a properly formed dimer, resulted in the production of virus particles with abnormal morphol- ...Since ... See full document
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An Intact TAR Element and Cytoplasmic Localization Are Necessary for Efficient Packaging of Human Immunodeficiency Virus Type 1 Genomic RNA
... for RNA packaging in human immunodeficiency virus (HIV) is lacking, it is widely believed that the HIV genome contains a packaging region that interacts with a viral ... See full document
9
Association of Human Immunodeficiency Virus Type 1 Vif with RNA and Its Role in Reverse Transcription
... viral RNA out of the nucleus to the cytoplasm ...genomic RNA itself, since the vif mutant fails to influence viral protein translation and RNA packaging, its position within the nucleus may ... See full document
8
Charged amino acid residues of human immunodeficiency virus type 1 nucleocapsid p7 protein involved in RNA packaging and infectivity.
... with RNA extracted from cos-1 cells transfected with a wild-type HIV-1 plasmid was ...with RNA extracted from untransfected cos-1 cells (A to C) and an RT-PCR lacking input ... See full document
10
Transduction of Human Immunodeficiency Virus Type 1 Vectors Lacking Encapsidation and Dimerization Signals
... vector RNA on its packaging, we compared the packaging of HIV vectors to that of overexpressed, nonviral ...total RNA was extracted from the transfected cells and from VLPs, respectively, in ... See full document
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